Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death. Therefore, it is critical for researchers to understand molecular biology in greater depth. In several diseases including cancer, abnormal miRNA expression has been linked to apoptosis, proliferation, differentiation, and metastasis. Many miRNAs have been studied in relation to cancer, including miR-122, miR-223, and others. Hepatitis B and C viruses are the most important global risk factors for HCC. This study is intended to test whether serum miRNAs serve as a potential biomarker for both HCC and viral infections HBV and C. The expression of miRNA in 64 serum samples was analyzed by RT-qPCR. Compared to healthy volunteers, HCC patients' sera expressed significantly lower levels of miR-122 and miR-223. Furthermore, we compared the expression of these miRNAs between early-diagnosed HCC patients and healthy controls. There was a significant difference between miR-122 expression in HCC sera and healthy volunteers' sera (0.000 and 0.253, respectively), with a P value of <0.0001. Early diagnostic patients without treatment had completely deleted miR-122 expression levels, while those treated had slightly elevated levels. Clearly, miR-122 has been identified as a biomarker for early detection and follow-up of HCC treatment. HBV and HCV specimens expressed significantly lower levels of miRNA than normal samples with a P value of <0.0001. It is recommended that these findings be further investigated for diagnostic purposes. Further, these miRNAs are highly specific for diagnosing HCC, HBV, and HCV, making them valuable therapeutic indicators.
The news of some of the Arab palaces that built in the Islamic cities were scattered in historical sources and references and was talking about the engineering and technical wonders that characterized these palaces, and Perhaps the purpose of mentioning its (often) was to show the extravagance and luxury that reached the palaces as a kind of condemnation of this act or to make visitors admire its masterpieces
Continued Ottoman rule in the Arab world until the end of World War I in 1918, and during the four centuries of Ottoman control, care of the Ottomans install and floating their rule, and to prevent the Arabs from the establishment of a political entity separate from the people to facilitate the rule of the Arab world and to ensure the
This paper deals with the meaning of cultural interaction in the hadith &also foundation that prophet (peace on him) followed through his invitation & rejecting all forms of injustice, oppression & racial discrimination.
The science of jurisprudence of the most honorable science, and engaged in the great reward with God Almighty; Today, they strive to highlight this tremendous wealth by searching for it, studying it, realizing it and presenting it to mankind for the purpose of benefiting from it.
It is a blessing to me that guided me to write in jurisprudence on the subject: (Delayed dowry in Islamic jurisprudence) Islamic law has preserved the rights of the wife to her husband, which is a financial and moral right. It is one of the provisions of the marriage contract and not a health condition and therefore marriage is held without mentioning in the contract.
This research aims to highlight the prophetic approach in civilized coexistence, and to show what society was like in the time of the Prophet, and specifically after the sakha and the writing of the newspaper (prophetic document) which established the rules of civilized coexistence, and there is no doubt that God almighty created all nations and different peoples according to Human nature, this difference has been recognized by the duty of coexistence and acquaintance without abolishing each other, coexistence and recognition of the other and respect for its particularities result in a state of dialogue between cultures and civilizations and paves the way for their meeting instead of clashing, as well as contributing coexistence to make
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العلمانية في الفكر الصهيوني المعاصر
النبات هو أول خلق الله تعالى ، جعله الله غذاء الانسان والحيوان حيث لا وجود للحياة من دونه ولا تستغني عنه الحياة. ومنذ ان خٌلِق الانسان والحيوان وجدت الامراض التي تنتابها ، ومثلما خلق الله الداء خلق ايضا الدواء واعطى الانسان غريزة الاهتداء الى نوع النبات الذي يشفيه من