Researcher Image
احمد سالم كاظم - Ahmed Salim Kadhim Al-Khafaji
PhD - assistant professor
College of Science , Department of Biology
[email protected]
Summary

Having worked on the investigation of the photodynamic effect on cancer cells in vitro and in vivo at ICCMGR during the period (2004 – 2007) followed by research work on Kleine-Levin Syndrome project under Prof. Anne-Marie Landtblom’s supervision at the Faculty of Medicine and Health Sciences, the University of Linköping, Sweden (2008-2009), my recent interests have been in the Molecular Biology of cancer. My PhD study (2011-2015) was a studentship granted from the University of Baghdad. Through my doctoral research, I sought to identify ten genes involved in the mitotic spindle checkpoint process (AURKA, AURKB, AURKC, CKAP5, DLGAP5, KIF11, TPX2, TTK, TUBB and TUBB3). I explored their potential to modulate taxane resistance in the human airways carcinomas with a focus on its most prevalent form of Non-Small Cell Lung Cancer (NSCLC). This work was performed as part of collaboration between two of the main research groups in the Department of Molecular & Clinical Cancer Medicine; the Roy Castle Lung Cancer Research Programme and the Mersey Head & Neck Oncology Group, co-located in the University of Liverpool Cancer Research Centre. In 2016, I re-joined the lung group as an Honorary Research Associate/ Postdoc under the line management of Dr Lakis Liloglou. During my honorary association, I have had a technical advisory role in the supervising teams of three PhD students during the period (2016- to present). In this aspect, I started to produce pilot results for enhancing grant application potentials. Based on the novelty of my research work, I was able to publish the findings in a number of peer-reviewed journals with high impact factor; the British Journal of Cancer and Oncology letters Journal. Recently, I have established research collaboration between Iraq (University of Baghdad and Ministry of Health & environment) and the UK (University of Liverpool) to develop an Iraqi Risk Model for Lung Cancer prediction and early detection screening programme in Iraq. I initiated this effort by establishing contact with key scientists from both the UK and Iraq. We (I and my collaborators) have already activated a recruitment process under the Iraq Healthy Lung Project (IHLP). I and my collaborators were successfully granted a University of Liverpool ODA Research Seed Fund. It represents the first joint grant application between the Universities of Liverpool and Baghdad that have been spent, as planned, to strengthen and expand the current network so that further funding can be applied for. Whilst Prof. John K Field (Clinical Professor of Molecular Oncology) was acting as Principal Investigator (PI), I was acting as Co-Investigator (Co-I) for the Iraqi contingent (including the University of Baghdad and Ministry of Health & Environment) took a very active role in the application alongside Dr Michael Davies at the University of Liverpool. I have recently been promoted to Director of the National Cancer Research Centre at the University of Baghdad and my honorary appointment at the University of Liverpool has been upgraded to Honorary Senior Research Fellow.

Qualifications

1993-1998 B.Sc. in Biology/ Microbiology, College of Science, University of Baghdad, Iraq. 1998-2002 M.Sc. in Biotechnology, College of Science, University of Baghdad, Iraq. 2011-2015 PhD in Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, Faculty of Health & Life Science, University of Liverpool, UK. 2016-2018 Postdoctoral Research Associate, Molecular and Clinical Cancer Medicine, University of Liverpool, UK.

Responsibility

2021-2022 Director of the National Cancer Research Centre, University of Baghdad, Iraq. 2021-2022 Head of the Administrative Board of the National Cancer Research Centre, University of Baghdad, Iraq.

Awards and Memberships

MEMBERSHIP

  1. Member in the International Association for the Study of Lung Cancer (IASLC), (2014-2015), USA.
  2. Member in European Association for Cancer Research (EACR), (2013-2015), European Union.
  3. COMMITTEES I. Permanent Committees
  4. Membership of the Iraqi Cancer Board, Ministry of Health, Iraq. (University of Baghdad order on 1st Jan 2022).
  5. Head of Scientific Committee of the National Cancer Research Centre, University of Baghdad, Iraq (2021-2022).
  6. Chair of the Biomedical Research Ethics Committee of the National Cancer Research Centre, University of Baghdad, Iraq (2021-2022).
  7. Establishing Higher Diploma in Forensic Biology Specialisation at the Dept. of Biology, College of Science, University of Baghdad (Administrative order on 26th May 2021).
  8. Gene mapping of thalassemia for controlling and preventing the disease in Iraq, Ministry of Health & environment, Iraq (Ministerial order on 17th April 2019).
  9. Quality Assurance and University Performance, Dept. of Biology, College of Science, University of Baghdad. 2017-present.
  10. Examination Committee, Dept. of Biology, College of Science, University of Baghdad. The academic year 2017-2018.
  11. Electronic quotation, Dept. of Biology, College of Science, University of Baghdad. 2018-present. II. Temporary Committees
  12. I have been nominated to chair more than 10 temporary committees, National Cancer Research Centre, University of Baghdad, Iraq.
  13. I have been nominated to act as a member in more than 25 temporary committees, Dept. of Biology, College of Science, University of Baghdad.
Research Interests

Molecular Biology, Cancer Biology, PCR techniques, NGS, Pyrocequencing, Cell Culture, Gene Expression, Cloning, Western Blot Analysis, Flow Cytometry, Microbiome... etc

Academic Area

Molecular Biology, Cancer Biology, DNA typing

Teaching

2019-present Asst. Prof. PhD. / Dept. of Biology, College of Science, University of Baghdad, Iraq. 2016-2019 Lecturer PhD. / Dept. of Biology, College of Science, University of Baghdad, Iraq. 2004-2016 Assistant Lecturer MSc. / Dept. of Biology, College of Science, University of Baghdad, Iraq. 2002-2004 Visiting Assistant Lecturer, MSc. / Dept. of Biology, College of Science, University of Baghdad, Iraq.

Supervision

SUPERVISION AND ADVISORY ROLES

  1. Technical Advisory Team Member for Three PhD. Students at the Department of Molecular and Clinical Cancer Medicine, Institutes of Translational Medicine, Faculty of Health & Life Science, University of Liverpool, UK (2016-2021).
  2. Supervisor of (3) M.Sc. Students at the Department of Biology, College of Science, University of Baghdad, Iraq (2020-present).
  3. Co-Supervisor of 3 PhD Students at the Faculty of Natural Sciences/ University of Tabriz/ Tabriz/ I. R. of Iran (2022-present).
  4. Scientific Advisor of Ibn-Sina Centre for Research, Corporation for Research and Industrial Development, Ministry of Industry and Minerals, Iraq (2020-present)
Publication Date
Fri Apr 07 2017
Journal Name
Oncology Letters
AURKA mRNA expression is an independent predictor of poor prognosis in patients with non-small cell lung cancer
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Publication Date
Tue Jan 17 2017
Journal Name
British Journal Of Cancer
Aurora B expression modulates paclitaxel response in non-small cell lung cancer
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Publication Date
Thu Mar 07 2024
Journal Name
Oncology Letters
Effect of valproic acid on histone deacetylase expression in oral cancer (Review)
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Publication Date
Thu Jul 11 2019
Journal Name
Turkish Journal Of Pharmaceutical Sciences
<i>In Vitro</i> Macrophage Nitric Oxide and Interleukin-1 Beta Suppression by Moringa peregrina Seed
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Scopus (20)
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Publication Date
Tue Jan 09 2018
Journal Name
Iraqi Journal Of Cancer And Medical Genetics
Photodynamic Action of low power He-Ne laser on photosensitized human Hep-2 and AMN3 cell lines with Hematoporphyrin derivative in vitro
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Photodynamic Action (PDA) by using appropriate wavelength of irradiation conjugated with porphyrin derivatives is a powerful mechanism of tumor destruction. Hematoporphyrin derivative has been shown to selectively localize in neoplastic cells and then cause destruction of them by generation of singlet oxygen when activated by low power He-Ne laser. Light which used in this study has been emitting from this laser has a wavelength equal to 632.8 nm (red light). Doses of laser had been varied from 3.6 J/cm2 to 14.4 J/cm2 . The beam of laser adjusted with a modified tissue culture plate. Cell lines had exposed to Hematoporphyrin D (HpD) for 24 hours before Laser exposure, their concentrations were varied from 5 µg/ml to 80 µg/ml. Resu

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Publication Date
Fri Jan 13 2023
Journal Name
World Academy Of Sciences Journal
Potential effects of miR‑146 expression in relation to malondialdehyde as a biomarker for oxidative damage in patients with breast cancer
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Publication Date
Sat Jan 28 2012
Journal Name
Rafidain Journal Of Science
Photodynamic Effect on Photosensitized Candida albicans with Hematoporphyrin Derivative Using Low Power Diode Laser In Vitro
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Publication Date
Sat Jan 05 2019
Journal Name
The Egyptian Journal Of Neurology, Psychiatry And Neurosurgery
Use of low-power He-Ne laser therapy to accelerate regeneration processes of injured sciatic nerve in rabbit
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Publication Date
Sun Jan 01 2023
Journal Name
Journal Of Advanced Pharmaceutical Technology & Research
Hesperetin effect on MLH1 and MSH2 expression on breast cancer cells BT-549
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Publication Date
Thu Jan 23 2020
Journal Name
Oncology Letters
Overexpression of HURP mRNA in head and neck carcinoma and association with in�vitro response to vinorelbine
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Publication Date
Mon Jan 01 2024
Journal Name
Journal Of Advanced Pharmaceutical Technology & Research
Exploring the modulation of MLH1 and MSH2 gene expression in hesperetin-treated breast cancer cells (BT-474)
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A<sc>BSTRACT</sc> <p>The major mortality factor for women globally is breast cancer, and current treatments have several adverse effects. Hesperetin (HSP) is a flavone that occurs naturally with anti-tumor capabilities and has been investigated as a potential treatment for cancer. This study aimed to investigate the cytotoxic and anti-malignant potential of HSP on breast cancer cells (BT-474) and normal cells (MCF-10a). The results indicated that HSP has dose-dependent cytotoxicity in BT-474 and MCF-10a cells. The elevated concentration of HSP lowered cell viability and proliferation. The half-maximal inhibitory concentration (IC<sub>50</sub>) of HSP in BT-</p> ... Show More
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Date
علم ما فوق الجينوم للسرطان
Panel Discussions حلقات نقاشية
2023-05-09