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Predictive Significance of Interleukins 17A and 33 in Risk of Relapsing–Remitting Multiple Sclerosis
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Cytokines are signaling molecules between inflammatory cells that play a significant role in the pathogenesis of a disease. Among these cytokines are interleukins (ILs) 17A and 33, and accordingly, the current case-control study sought to investigate the role of each of the two cytokines in the risk of developing multiple sclerosis (MS). Sixty-eight relapsing-remitting MS (RRMS) Iraqi patients and twenty healthy individuals (control group) were enrolled. Enzyme linked immunosorbent assay (ELISA) kits were used to determine serum levels of IL-17A and IL-33. Results revealed that IL-17A and IL-33 levels were significantly higher in MS patients than in controls (14.1 ± 4.5 vs. 7.5 ± 3.8 pg/mL; p < 0.001 and 65.3 ± 16.3 vs. 49.3 ± 20.0 pg/mL; p < 0.001, respectively). Receiver operating characteristic (ROC) curve analysis demonstrated that IL-17A was a very good predictor of MS (area under curve [AUC] = 0.869; 95% CI = 0.779 - 0.960; p < 0.001; cut-off value = 10.2 pg/mL; sensitivity = 80.8%; specificity = 75.0%). A similar prediction was presented by IL-33, but the AUC value was lower (AUC = 0.762; 95% CI = 0.63 - 0.89; p < 0.001; cut-off value = 56.4 pg/mL; sensitivity = 70.6%; specificity = 70.0%). Multinomial logistic regression analysis confirmed the significance of IL-17A and IL-33 in MS risk, and under three models of analysis, the estimated odds ratios for IL-17A (1.50, 1.49 and 1.50, respectively) and IL-33 (1.05, 1.05 and 1.06) were above 1.0. Patients stratified by gender (male and female), expanded disability status scale (EDSS: < 3 and ≥ 3) or medication (pre- and post-medication) showed no significant differences in serum levels of IL-17A and IL-33 for each stratum. However, with regard to response to medication, it was found that responding patients showed significantly higher levels of IL-33 than non-responders (70.9 ± 12.2 vs. 57.2 ± 18.2 pg/mL; p = 0.018). This difference was not observed when considering IL-17A. Pearson correlation analysis between IL-17A and IL-33 revealed that both cytokines were not significantly correlated. In conclusion, the study indicated that IL-17A and IL-33 were up-regulated in serum of MS patients, and this up-regulation was not influenced by age, gender, EDSS or medication status, but the elevated level of IL-33 was more pronounced in patients who responded to medication.

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Publication Date
Mon Jun 09 2025
Journal Name
ايسن للاثار والتاريخ واللغات القديمة
طائرات الدرون الخصائص والاستخدامات في حقل الاثار
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الملخص شاع في الآونة الأخيرة استخدام طائرات الدرون في عمليات المسح والتوثيق الحقلي للمواقع الاثرية، حتى اصبح استخدام الدرون ضرورة أساسية تسبق أي عملية تنقيب اثري، من هذا المنطلق جاءت فكرة البحث لايضاح المبهم وإعطاء الأجوبة المناسبة لكثير من الأسئلة التي تطرح من قبل دارسي ومختصي الاثار، وسلط البحث الضوء على كل مايخص مفهوم الدرون وبدايات استخدامها في علم الاثار، واهم مكوناتها واجزائها الأساسية وخصائصها

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Publication Date
Wed Jun 02 2021
Journal Name
مجلة جامعة الانبار للعلوم الانسانية
استخدام العلوم الحديثة في التنقيب عن الاثار
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المستخلص ان هدف التنقيب عن الآثار هو في الأساس لحماية الآثار التي في باطن الارض وذلك لغرض دراستها والتعرف عليها للوصول الى الحقائق التي تخص مختلف العصور التي مرت على تلك المنطقة الأثرية ، وانطلاقا من هذا الهدف ستكون الطرق والوسائل العلمية المساعدة في عمليات التنقيب والحفر بأسلوب يضمن سلامة الأثر وحفظ المعلومات عنه وصيانته هي موضوع بحثنا هذا وسنحاول ان نركز على أهم الطرق العلمية الحديثة التي ظهرت في الف

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Publication Date
Mon Apr 29 2019
Journal Name
Arab Science Heritage Journal
كسر كسر أفق التوقع في الشعر الجاهلي
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It is an effect to draw attention to the aesthetic aspects and dedication And sounding the horizon of expectation among the public- the recipients- and knowing his taste

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Publication Date
Fri Jan 01 2016
Journal Name
Journal Of The College Of Languages (jcl)
Étude des aspects de la peur Dans « La Peste » d'Albert Camus
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Resumé

La Peste, paru en 1947 et qui reçoit le prix des critiques acquiert a Camus  une notoriété universelle, il reçoit en 1957 le prix Nobel pour une œuvre qui, selon les termes de l’Académie suédoise : « met en lumière les problèmes se posant de nos jours à la conscience des hommes ». A Oran où il n’arrive jamais rien, quelque chose va arriver. On découvre un rat mort, couvert de sang. Deux jours après on en trouve des centaines, puis des milliers. Deux semaines plus tard, un homme meurt d’une maladie, décrite avec précision, mais sans recherche de l’horreur. Après cet événement, on signale une dizaine, puis une vingtaine de cas de fiè

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Publication Date
Tue Jan 01 2013
Journal Name
Journal Of The College Of Languages (jcl)
Gabriel Celaya Poesίa Comprometida del Amor y la Vida. Un Estudio Literario Crítico.
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El moviemiento literario español de posguerra ha visto un cambio muy transcendental al nivel de plantear los temas y la  técnica de formar el genero literario ,de forma que la poesίa ha ocupado un espacio muy significativo en ello ,dado que los poetas buscaban metedos creativos para atraer el público , siguiendo senedores que pudieran afectar de forma u otra en las mentes y sentimientos.

        En esta dirección ,Gabriel Celaya se resalta como voz que ha  traspasado el ánimo de dos promociones genericas que son la de 27 y la de 36, por lo cual podίa conllevar unas asencias muy basicas de la poesίa española que envuelven la precisión clásica y prodencia contemporanea, con

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Publication Date
Fri Mar 02 2018
Journal Name
مجلة اوروك للعلوم الانسانية
مشكلة مسلمي الرةهينجا دراسة في الجغرافية السياسية
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يُعد الاضطهاد الديني في ميانمار من أبرز القضايا الإنسانية والسياسية في جنوب شرق آسيا، إذ تعاني بعض الأقليات الدينية، خصوصًا المسلمين والمسيحيين، من التمييز والقيود والانتهاكات المستمرة

Publication Date
Wed Jan 01 2014
Journal Name
Journal Of The College Of Languages (jcl)
La voix de la mère dans À la Recherche du Temps perdu
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Abstract

The twentieth century French novel had undergo a significant change that took the form of a radical move from the traditional son who follows his father to one who no way prevalent in the classical French novel. The new son in the 2Oth century novel finds himself emotionally attached which both became a new trend and approach in novel writing.

Marcel Proust's novel which can be considered a source of inspiration for most of 2Oth century novelists is a good example of the mother supremacy which is crystal clear from the first page through its parts and chapters till the last page. In fact, Proust had written a completely different novel from the Balzacian conventions. Unlike the latter's novels, Pro

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Publication Date
Sat Jan 01 2005
Journal Name
Journal Of The College Of Languages (jcl)
التطور الدلالي لمعاني الكلمات في اللغة العبرية
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التطور الدلالي لمعاني الكلمات في اللغة العبرية

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Publication Date
Fri Sep 01 2023
Journal Name
Al-khwarizmi Engineering Journal
Tracked Robot Control with Hand Gesture Based on MediaPipe
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Hand gestures are currently considered one of the most accurate ways to communicate in many applications, such as sign language, controlling robots, the virtual world, smart homes, and the field of video games. Several techniques are used to detect and classify hand gestures, for instance using gloves that contain several sensors or depending on computer vision. In this work, computer vision is utilized instead of using gloves to control the robot's movement. That is because gloves need complicated electrical connections that limit user mobility, sensors may be costly to replace, and gloves can spread skin illnesses between users. Based on computer vision, the MediaPipe (MP) method is used. This method is a modern method that is discover

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Publication Date
Sun Feb 25 2024
Journal Name
Baghdad Science Journal
Sentiment Analysis on Roman Urdu Students’ Feedback Using Enhanced Word Embedding Technique
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Students’ feedback is crucial for educational institutions to assess the performance of their teachers, most opinions are expressed in their native language, especially for people in south Asian regions. In Pakistan, people use Roman Urdu to express their reviews, and this applied in the education domain where students used Roman Urdu to express their feedback. It is very time-consuming and labor-intensive process to handle qualitative opinions manually. Additionally, it can be difficult to determine sentence semantics in a text that is written in a colloquial style like Roman Urdu. This study proposes an enhanced word embedding technique and investigates the neural word Embedding (Word2Vec and Glove) to determine which perfo

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