Cytokines are signaling molecules between inflammatory cells that play a significant role in the pathogenesis of a disease. Among these cytokines are interleukins (ILs) 17A and 33, and accordingly, the current case-control study sought to investigate the role of each of the two cytokines in the risk of developing multiple sclerosis (MS). Sixty-eight relapsing-remitting MS (RRMS) Iraqi patients and twenty healthy individuals (control group) were enrolled. Enzyme linked immunosorbent assay (ELISA) kits were used to determine serum levels of IL-17A and IL-33. Results revealed that IL-17A and IL-33 levels were significantly higher in MS patients than in controls (14.1 ± 4.5 vs. 7.5 ± 3.8 pg/mL; p < 0.001 and 65.3 ± 16.3 vs. 49.3 ± 20.0 pg/mL; p < 0.001, respectively). Receiver operating characteristic (ROC) curve analysis demonstrated that IL-17A was a very good predictor of MS (area under curve [AUC] = 0.869; 95% CI = 0.779 - 0.960; p < 0.001; cut-off value = 10.2 pg/mL; sensitivity = 80.8%; specificity = 75.0%). A similar prediction was presented by IL-33, but the AUC value was lower (AUC = 0.762; 95% CI = 0.63 - 0.89; p < 0.001; cut-off value = 56.4 pg/mL; sensitivity = 70.6%; specificity = 70.0%). Multinomial logistic regression analysis confirmed the significance of IL-17A and IL-33 in MS risk, and under three models of analysis, the estimated odds ratios for IL-17A (1.50, 1.49 and 1.50, respectively) and IL-33 (1.05, 1.05 and 1.06) were above 1.0. Patients stratified by gender (male and female), expanded disability status scale (EDSS: < 3 and ≥ 3) or medication (pre- and post-medication) showed no significant differences in serum levels of IL-17A and IL-33 for each stratum. However, with regard to response to medication, it was found that responding patients showed significantly higher levels of IL-33 than non-responders (70.9 ± 12.2 vs. 57.2 ± 18.2 pg/mL; p = 0.018). This difference was not observed when considering IL-17A. Pearson correlation analysis between IL-17A and IL-33 revealed that both cytokines were not significantly correlated. In conclusion, the study indicated that IL-17A and IL-33 were up-regulated in serum of MS patients, and this up-regulation was not influenced by age, gender, EDSS or medication status, but the elevated level of IL-33 was more pronounced in patients who responded to medication.
قسم المؤلف كتابه على ستة فصول تسبقها مقدمة وتعقبها حالمة، فقد أبانت المقدمة الدوافع والأسباب التي تقف وراء عنوان الكتاب، إذ وصفه بأنه يجمع بين دفتيه مادة علمية غايتها التعرف على بعض الأديان التي يدين معظم البلدان مع بيان تاريخ نشأتها ومناصريها. وقد حدد الديانات التي سيقتصر الكتاب على دراستها، وهي: الصابئة المندائيين والديانات الهندوسية والبوذية، والجينية والكونفوشية في الصين والشتوية في اليابان كونها من ا
... Show Moreنسب أغلب مؤرخي العلم الإنساني الطرق التي إتبعت في كتابة المنهج العلمي الصحيح ، في كافة العلوم و المعارف ، إلى العصر الحديث . و قال آخرون ان العقل البشري ، سواء في الأزمنة القديمة أو الحديثة ، هو واحد لا يمكنه التفكير أو العمل إلا بوجود منهج معين يسير عليه فكره و فعله (1) ، مطلقين عليه تسمية المنهج التلقائي . و كما هو واضح من التسمية يمكن وصفه بأنه منهج يفتقر إلى الإدراك و الشعور . و يطبق هذا المنهج الغالبية ا
... Show MoreIslamic banking refers to a system of banking or banking activity that is consistent with the principles of the Shari'ah (Islamic rulings) and its practical application through the development of Islamic economics. The principles which emphasise moral and ethical values in all dealings have wide universal appeal. Shari'ah prohibits the payment or acceptance of interest charges (riba) for the lending and accepting of money, as well as carrying out trade and other activities that provide goods or services considered contrary to its principles. While these principles were used as the basis for a flourishing economy in earlier times, it is only in the late 20th century that a number of Islamic banks were formed to provide an alternative basi
... Show Moreيعد موضوع المحل من المواضيع الشائكة في القانون المدني ، اذ ان هذا الموضوع رغم قدمه الا انه لازال يمثل ارضا خصبة للبحث ، اذ يوجد خلاف حول تحديد الكائن القانوني الذي يعد المحل ركنا فيه ، حيث اختلفت التشريعات في هذه المسألة ، فبعض التشريعات تذهب الى ان المحل ركن في العقد ، وبعضها يذهب الى ان المحل ركن في الالتزام ، وبعضها يذهب الى ان المحل ركن في العقد وركن في الالتزام وقد انتقل هذا الخلاف الى الفقه فظهر فيه عدة اتج
... Show Moreالملخص الضاد والظاء موطن تفرّد العربية وفخرها ، ألّفت فيهما العشرات والعشرات من المصنّفات الثرّة لكثرة ذرائع تلابسهما والخلط بينهما ، فهما متشابهان في هيكل البناء ، وإخراجهما متداخل على اللسان ، وألفاظهما متناظرة برحابة في الإملاء ، فضلاً عن سريان إشكالهما إلى حدّ الآن ، مما حثّني على التفكير في وسائل تسهّل المطروح وتمدّ جسراً بين أجزائه عسى أن تدنو قِطافُهُ في دفع الشبهة ومواراتها ، فتحصّلت لي أمور أذعتُها
... Show MoreThe comparative literature is a branch of literary criticism which Point to the literary association and relation connecting a mong different world nations and the effect of a nations literature and Culture on another nations literature and culture .So the comparative literature is an image and affront of influence on another nation and countrys literature and culure, for example, the effect of Arabic literature on the Persian , French , English Turkish, Indian and Chinese literature and vice aversa . The current research includes three sections .The first section refers to the meaning and definition of the term “comparative literature '', its origin and beginning s. While the second section focuses on the beginning of the comparative
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