Preferred Language
Articles
/
bsj-6431
Predictive Significance of Interleukins 17A and 33 in Risk of Relapsing–Remitting Multiple Sclerosis
...Show More Authors

Cytokines are signaling molecules between inflammatory cells that play a significant role in the pathogenesis of a disease. Among these cytokines are interleukins (ILs) 17A and 33, and accordingly, the current case-control study sought to investigate the role of each of the two cytokines in the risk of developing multiple sclerosis (MS). Sixty-eight relapsing-remitting MS (RRMS) Iraqi patients and twenty healthy individuals (control group) were enrolled. Enzyme linked immunosorbent assay (ELISA) kits were used to determine serum levels of IL-17A and IL-33. Results revealed that IL-17A and IL-33 levels were significantly higher in MS patients than in controls (14.1 ± 4.5 vs. 7.5 ± 3.8 pg/mL; p < 0.001 and 65.3 ± 16.3 vs. 49.3 ± 20.0 pg/mL; p < 0.001, respectively). Receiver operating characteristic (ROC) curve analysis demonstrated that IL-17A was a very good predictor of MS (area under curve [AUC] = 0.869; 95% CI = 0.779 - 0.960; p < 0.001; cut-off value = 10.2 pg/mL; sensitivity = 80.8%; specificity = 75.0%). A similar prediction was presented by IL-33, but the AUC value was lower (AUC = 0.762; 95% CI = 0.63 - 0.89; p < 0.001; cut-off value = 56.4 pg/mL; sensitivity = 70.6%; specificity = 70.0%). Multinomial logistic regression analysis confirmed the significance of IL-17A and IL-33 in MS risk, and under three models of analysis, the estimated odds ratios for IL-17A (1.50, 1.49 and 1.50, respectively) and IL-33 (1.05, 1.05 and 1.06) were above 1.0. Patients stratified by gender (male and female), expanded disability status scale (EDSS: < 3 and ≥ 3) or medication (pre- and post-medication) showed no significant differences in serum levels of IL-17A and IL-33 for each stratum. However, with regard to response to medication, it was found that responding patients showed significantly higher levels of IL-33 than non-responders (70.9 ± 12.2 vs. 57.2 ± 18.2 pg/mL; p = 0.018). This difference was not observed when considering IL-17A. Pearson correlation analysis between IL-17A and IL-33 revealed that both cytokines were not significantly correlated. In conclusion, the study indicated that IL-17A and IL-33 were up-regulated in serum of MS patients, and this up-regulation was not influenced by age, gender, EDSS or medication status, but the elevated level of IL-33 was more pronounced in patients who responded to medication.

Scopus Clarivate Crossref
View Publication Preview PDF
Quick Preview PDF
Publication Date
Thu Dec 13 2018
Journal Name
Arab Science Heritage Journal
ال أل العاقولي ودورهم العلمي في الحضارة العربية الإسلامية
...Show More Authors

The research includes a bout IL- IQulle , and their role in scientific of the Islamic – Arabic civilization , for Dr. Khlood M.Namma the proff in the collage of education for woman , Baghdad university , History department .

View Publication Preview PDF
Publication Date
Sun Apr 01 2012
Journal Name
Journal Of Educational And Psychological Researches
حقوق الطفل في ظل الأزمات المجتمعية /الطفل العراقي انموذجا
...Show More Authors

Rights of child in the community crisis Iraqi child model The study aimed to identify the types of violation against children in the Iraqi crisis as well as to develop community coping mechanisms to these violations and promote the rights of the child health psychological , social and legal . the first chapter discusses the research problem and its importance and purpose of the research problem and its importance and purpose of the research and the most important terms in the A- Rights of the child ,B- crisis , chapter 2 rights of the child ensure the historical roots , of children’s rights in the holy quran and the sunnah, and legal rights through the twentieth century and the beginnings of century xx, the se through the twentieth cen

... Show More
View Publication Preview PDF
Publication Date
Thu Jun 15 2017
Journal Name
مجلة العلوم الاجتماعية
الشفقة بالذات لدى طلبة الجامعة في ضوء بعض المتغيرات
...Show More Authors

هدفت الدراسة التعرف على الشفقة بالذات لدى الطلبة فضلا عن التعرف على الفروق في الشفقة بالذات وفق متغيرات : الجنس –التخصص الدراسي – المرحلة الدراسية، تالفت عينة الدراسة من (200) طالب وطالبة موزعين بالتساوي حسب الجنس (ذكور – اناث) والتخصص الدراسي (علمي - انساني) والمرحلة الدراسية ( الاولى - الرابعة )، وبعد تطبيق مقياس الدراسة وتحليل الاجابات احصائيا ، اظهرت النتائج ان الطلبة لديهم شفقة بالذات كما اظهرت النتائج عدم

... Show More
View Publication Preview PDF
Publication Date
Fri Jan 04 2019
Journal Name
Journal Of Planner And Development
تمهيد اجتماعي قبل اعمار الصحراء بحث في السلوك الاجتماعي
...Show More Authors

View Publication Preview PDF
Publication Date
Wed Dec 20 2023
Journal Name
Arab Science Heritage Journal
إلرشادات النبوية في إستخدام أواني الطعام والشراب وأثرها الصحي
...Show More Authors

The research included the statement of some prophetic
guidelines for preserving food and drink from contamination that
causes diseases, which originate either viruses and microbes, or
insects and vermin spread in the air,

View Publication Preview PDF
Publication Date
Sun Dec 23 2018
Journal Name
Arab Science Heritage Journal
التفسير التفسير النبىي للقرآن الكريم وأحره في التفسير بالمأحىر
...Show More Authors

The science of exegesis was started by the first teacher, the Holy Prophet, and then further developed in various methods and approaches through history

View Publication Preview PDF
Publication Date
Tue Jul 16 2024
Journal Name
مجلة دراسات المرأة
" الأمن البيئي ودور المرأة في الحفاظ على الموارد الطبيعية
...Show More Authors

يعد الأمن البيئي موضوعاً حيوياً لا سيما في العصر الحديث، حيث بدأت تحديات التغير المناخي تتدهور وبسرعة متزايدة. وتزداد أهمية هذا الموضوع مع تصاعد تلك التحديات، أذ يتعين على الجميع لا سيما النساء منهم المشاركة في الحفاظ على البيئة لضمان استدامتها للأجيال الحالية والمستقبلية. ويُعد الحفاظ على البيئة والموارد الطبيعية أمراً ضرورياً لضمان استدامة الكوكب ومستقبل الأجيال القادمة. وفي هذا السياق، يأتي دور المرأة

... Show More
Preview PDF
Publication Date
Tue Jun 01 2010
Journal Name
Journal Of Economics And Administrative Sciences
مقارنة بعض المقدّرات الحصينة في دوال التمييز بأستخدام المحاكاة
...Show More Authors

The development in manufacturing computers from both (Hardware and Software) sides, make complicated robust estimators became computable and gave us new way of dealing with the data, when classical discriminant methods failed in achieving its optimal properties especially when data contains a percentage of outliers. Thus, the inability to have the minimum probability of misclassification. The research aim to compare robust estimators which are resistant to outlier influence like robust H estimator, robust S estimator and robust MCD estimator, also robustify misclassification probability with showing outlier influence on the percentage of misclassification when using classical methods. ,the other

... Show More
View Publication Preview PDF
Crossref
Publication Date
Sun Oct 01 2006
Journal Name
Journal Of Educational And Psychological Researches
الكفايات التدريسية اللازمة لمدرسي التربية الإسلامية في المرحلة الإعدادية
...Show More Authors

مشكلة البحث :

إن القرآن الكريم هو النور المبين والذكر الحكيم يحتوي على الغاية الأسمى التي تهدف اليها الإنسانية ، فهو روح التربية الإسلامية وهو المنهج القديم الذي تستمد منه فلسفتنا التربوية واتجاهاتها ،                                        (الزوبعي ، 1974: 18)

إن الدين الإسلامي هو نظام الهي

... Show More
View Publication Preview PDF
Publication Date
Thu Oct 01 2015
Journal Name
Al-academy
The Factors influencing to the cognition operation & its Data: وفاء جاسم محمد
...Show More Authors

The present research deals with the influencing factors which depends on the way perceptual of the graphic designer which enters in the design logos of the loco European health, where the search include four chapters, the researcher reviewed in the chapter 0ne the methodical frame of the research ,as reviewed in the second chapter the theoretical frame, and the previous studies which included three sections, the first section included the perceptual understandable and types of it, and the second section included the influencing factors in the designer perceptual ways and its division . While the third section included the perceptual in graphic designer through the percepted shapes and the relation with ground and colors for express the i

... Show More
View Publication Preview PDF
Crossref