The biomarker significance of three chemokines (CXCL8, CXCL10 and CXCL16) was evaluated in sera of 45 breast cancer (BC) and 28 benign breast lesion (BBL) patients, as well as 20 control women. Clinical stage and tumor expression of estrogen (ER), progesterone (PgR) and human epidermal growth factor receptor-2 (HER-2) receptors were considered in this evaluation. The results demonstrated that CXCL8, CXCL10 and CXCL16 showed a significant increased median in BC and BBL patients compared to control (CXCL8: 47.3 and 25.7 vs. 15.0; CXCL10: 37.6 and 30.7 vs. 13.1; CXCL16; 27.9 and 25.2 vs. 19.2 pg/ml, respectively). The increased levels of CXCL8 and CXCL16 were more pronounced in triple-negative and HER-2 positive patients, respectively. Binary logistic regression analysis revealed that CXCL8 was a significant predictor of BC, and such prediction was more depicted in triple-negative patients. The receiver operating characteristic analysis also revealed that CXCL8 recorded an area under curve of 0.998 in BC patients. In conclusion, CXCL8 is a potential biomarker for BC, especially when ER, PgR and HER-2 expression is considered. In this context, the predictive significance of CXCL8 in influencing BC progression is suggested in triple-negative patients.
يستهدف البحث التعرف على اهمية التعلم باللعب لاطفال رياض الاطفال وانعكاساتها على تعديل سلوكهم، حيث ان اللعب هو دنيا الطفل المليئة بالمتعة والاستطلاع والاستكشاف، كما ان اللعب بالنسبة للاطفال يمثل لهم الحياة بكل ما فيها من معنى.
وفي الوقت نفسه اللعب هو وسيلة من وسائل الضبط والتوجيه للتعامل مع سلوك الاطفال، فمن خلال اللعب نستكشف النبوغ والتفوق منذ وقت مبكر، حيث ان التعلم باللعب يمثل حاجة حيو
... Show Moreعاش البيروني في القرن الرابع الهجري الذي كان يمثل مثاراً للصراعات السياسية والفكرية، ومن خلال هذه الأوضاع المتأزمة برز البيروني كعلم من اعلام هذا القرن، ومن أبرز مفكري الحضارة العربية الاسلامية فنجده كتب في الرياضيات
لمحة عن حالة حقوق الانسان في كوردستان العراق
Women are a social entity and can not be ignored starting from the process of creation Almighty and through the fact that it represents half of society and a fundamental factor and the corner can not be dispensed with in the composition of the family it is no longer acceptable to leave women to perform their role social and cultural or competitive and political role and in all aspects of political activity, It was not only women but the entire society lived loss, anxiety and oppression, a natural state created by deviation from the teachings and values of civil and followers of the corrupt positions in perception and conscience and behavior and links and relations and transactions until corruption became prevalent in all Social, economic
... Show Moreأرادة الذات بين الأستلاب والأسترداد في قصيدة البياتي
Praise be to God, prayer and peace upon our master Muhammad the Messenger of Allah peace be upon him mercy, gift, and grace, and rendered his family and the good righteous is followed until the Day of Judgment. After: The Koran
تنشر الدولة الفرنسية قواتها العسكرية في جميع دول القارة الافريقية بهدف السيطرة عليها وتحقيق مصالحها الشخصية
This research shows Ibn Battuta's approach in his book Ibn Battuta's Journey that is called "Tuhfet Al-Anzar fi Ghera'ib Al-Amsar wa Eaja'ib-Al-Asfar", which explore the urban aspects of shops, markets, palaces, houses, mosques, monasteries and other antiquities within its pages, whether in terms of the site or in terms of studying it and the plans that explained the basis for the art and architecture of these cities, the intellectual dimensions in their civilizational history are clarified
Books of plans are a type of writing in Islamic history , its a type of work whose authors have strived to serve as a comprehensive historical encyclopedia, and they focused most of their attention on highlighting the various aspects of the history of Egypt