The biomarker significance of three chemokines (CXCL8, CXCL10 and CXCL16) was evaluated in sera of 45 breast cancer (BC) and 28 benign breast lesion (BBL) patients, as well as 20 control women. Clinical stage and tumor expression of estrogen (ER), progesterone (PgR) and human epidermal growth factor receptor-2 (HER-2) receptors were considered in this evaluation. The results demonstrated that CXCL8, CXCL10 and CXCL16 showed a significant increased median in BC and BBL patients compared to control (CXCL8: 47.3 and 25.7 vs. 15.0; CXCL10: 37.6 and 30.7 vs. 13.1; CXCL16; 27.9 and 25.2 vs. 19.2 pg/ml, respectively). The increased levels of CXCL8 and CXCL16 were more pronounced in triple-negative and HER-2 positive patients, respectively. Binary logistic regression analysis revealed that CXCL8 was a significant predictor of BC, and such prediction was more depicted in triple-negative patients. The receiver operating characteristic analysis also revealed that CXCL8 recorded an area under curve of 0.998 in BC patients. In conclusion, CXCL8 is a potential biomarker for BC, especially when ER, PgR and HER-2 expression is considered. In this context, the predictive significance of CXCL8 in influencing BC progression is suggested in triple-negative patients.
The purpose of this research is to identify the E-signing and its concept.
Due to the increasing role and importance of the E-trade in may countries, as it provide many advantages over the traditional trade. We have to deal with may E-trade aspects and tools in which the E-signing is the most important. In this research we will deal: first with the article approach- E-signing definition, Digital signing, its mechanism, requirements, types and features. Second: the practical approach: It has been implemented according to a questionnaire contain many questions some of them are comma, other an specialized in research hypothesis and some concern the obstacles faced the application of E-signing. The questionnaires been distillated to
... Show Moreدراسة تحليلية لترجمة المسكوكات اللغوية في الصحافة الاسبانية.
تتباين القراءة والكتابة من ناقد لآخر تبعا للموضوع الذي يتناوله، وطبيعة المادة، والمكونات المعرفية التي تؤسس فهمه، فمنهم الناقد التقليدي الذي يتبع السائد في نقده للمادة الفنية اما بالموافقة والتبني أو بالمغالطة والقدح، ومنهم الناقد المقلد الذي ينتخب اتجاها غربيا يرغب في تطبيقه على جزء من النصوص التي انتقاها، ومنهم الناقد الذي يتبع أفكاره ويدمجها مع النص ناقد مختلف يبحث في ما يذلل من قواعد، يحلل ويشرح وفقها
... Show Moreالمبادئ العامة للقانون ودرها في اطار التجارة الدولية
The poverty in the developing countries is output to under development as we consider welfare, where as when the poverty disappear that produced be the general development . Historically, in our countries, the underdevelopment is the result of colonialism period and what is associated with it of transferring the surplus abroad and the disorder of production structure. And at the present time, the poverty is reproduced and aggravated in the last years as a result of many internal and external reasons.Today, poverty is associated in many forms with the poverty previously.
المقدمة
اضاءات على الانتخابات الشريعية في العراق عام 2010
Economic life in any of the countries depends mainly on economic activity due to its great role in meeting the needs and expenditures of the state . therefore ، Bahrain played a major role in commercial exchange operation ، whether at home or abroad . whatever the matter
: The objective of this research is to demonstrate the possibility of applying the principles of corporate governance in the General Authority for taxes, as the goal to identify the basic requirements for the application of the principles of corporate governance in the GCT with an indication of the role of governance in improving the strategic performance of tax administration. The research was based in part applied to the analysis of the results form questionnaire designed to achieve the goal of the research .
המחקר מתייחס לתופעת ההקטנה משני ענפים את הסימנטיקה והמורפופונולוגיה בשפה העברית, ומנסה ליגלוי את המשמעות בתוך ההקשר של צורות ההקטנה לדוגמאות מן התורה טקסטים מחדשות, שירה וסיפורים, הרי שחלק מהמשמעויות של מבנה הפלט עומדות בניגוד למשמעויות הבסיס או הדרגה במשמעות, כך מביעות על (הקטנה, חיבה, או זלזול) שרובן לא התקיימו בעברית הקלאסית, מצד אחר המחקר בדק במבנים המורפולוגיים במייוחד (המשקלים של צורת ההקטנה) ומבחין את
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