The biomarker significance of three chemokines (CXCL8, CXCL10 and CXCL16) was evaluated in sera of 45 breast cancer (BC) and 28 benign breast lesion (BBL) patients, as well as 20 control women. Clinical stage and tumor expression of estrogen (ER), progesterone (PgR) and human epidermal growth factor receptor-2 (HER-2) receptors were considered in this evaluation. The results demonstrated that CXCL8, CXCL10 and CXCL16 showed a significant increased median in BC and BBL patients compared to control (CXCL8: 47.3 and 25.7 vs. 15.0; CXCL10: 37.6 and 30.7 vs. 13.1; CXCL16; 27.9 and 25.2 vs. 19.2 pg/ml, respectively). The increased levels of CXCL8 and CXCL16 were more pronounced in triple-negative and HER-2 positive patients, respectively. Binary logistic regression analysis revealed that CXCL8 was a significant predictor of BC, and such prediction was more depicted in triple-negative patients. The receiver operating characteristic analysis also revealed that CXCL8 recorded an area under curve of 0.998 in BC patients. In conclusion, CXCL8 is a potential biomarker for BC, especially when ER, PgR and HER-2 expression is considered. In this context, the predictive significance of CXCL8 in influencing BC progression is suggested in triple-negative patients.
Philology is a science concerned with issues raised about language. It is a research into the mental aspects of its origin in its various sciences. The term (philology) appeared in the writings of Arab scholars in the fourth century AH. One of the most prominent topics of philology is research on the origin and development of language; Because it is one of the topics that preoccupied thinkers and many scholars, philosophers, and theologians, as well as linguists, have tackled research in it.
تحتكم العملية البنائية في المنجز الخطي الى م6جموعة من العوامل والمتغيرات المترابطة بتسلسل منطقي، لتنتج رؤية موحدة لإنجاز عمل فني تتوافر فيه الابعاد الوظيفية والجمالية والتعبيرية، ففي بنائية النسق الفني ليس المهم هو العنصر بقدر أهمية نظام العلاقات الذي يجعل هذا العنصر البنائي ينسجم مع باقي العناصر، وبالتالي تبرز قيمته كونه داخل بنية تنطوي على ضبط مكوناتها بدقة، لتفضي الى تقديم منجز للمتلقي منبثق من رؤية فا
... Show MoreThe status of science and scientists in the Arab Islamic state a prominent place was a signal the Koran to this position by encouraging people to seek knowledge as well asgive a prominent place for science and scientists, as confirmed by the Sunnah to this position through the Hadith as well as through height and this is what encourages peopleto take care of these things are important to the progress of the state and society and to
اهتم العرب بالجواهر والاحجار الكريمة منذ القدم وازداد هذا الاهتمام في حقب الترف والحضارة . ولم يقتصر استخدام الجواهر والاحجار على الطبقات الغنية كالخلفاء والامراء والوزراء بل شمل كل شرائح المجتمع الاخرى لان الاحجار
جاءت هذه الورقة البحثية لتبين اهمية التلفزيون في حياة النشىء من حيث بناء شخصيته واكسابه مايلزم من المهارات التي تعدهم الاعداد الافضل للحياة في حاضرها ومستقبلها ولتظهر دوره كوسيلة تعليمية معينة يمكن الاستفادة منها في العملية التربويةفي البيت والروضة والمدرسة ولتواكب مراحل حياة الاطفال وخصائص النمو العقلي والجسمي والانفعالي في كل مرحلة
دور التعايش السلمي في تحقيق الوحدة الوطنية
The urban Gentrification is an inclusive global phenomenon to restructure the cities on the overall levels, the research to propose a specific study about the concept of urban Gentrification in the cities and showcasing its, specifications, and results, and how to deal with the variables that occur on cities through improvements as part of urban renewal projects, then the general axis of the research is shrinked, choosing the urban centers as the most important areas that deal with the urban Gentrification process due to its direct connection with indivisuals and social changes, and to process the specific axis of the research theses and studies will be showcased that discuss the topic in different research directions, and emerged
... Show MoreThe presence of the other representations in the story of modern Arabic
The other who seek to discuss his presence is the other west, and is nothing new to bring the other whatever, especially the Western literature, especially after the opening of the East West and the occurrence of encounters many Whatever the reasons for them or their causes, and the prevalence of the phenomenon influenced by this Western, and therefore his presence in this literature of any had sex. And certainly our presence (we) also in the literature of the other, and this is very natural, created by the convergence of intellectual, cultural and human, which led to the emergence of the cultural theme of conflict between East and West, and these conflicts take d
البحث معني بظاهرة اللجوء من العالم الاسلامي الى العالم الغربي وما يحيط بهذه الظاهرة من تحديات سواء كانت سلبية او ايجابية والبحث يوضح احكام العقيدة الاسلامية للحكم على هذه الظاهرة التي اصبحت من النوازل في هذا العصر