The biomarker significance of three chemokines (CXCL8, CXCL10 and CXCL16) was evaluated in sera of 45 breast cancer (BC) and 28 benign breast lesion (BBL) patients, as well as 20 control women. Clinical stage and tumor expression of estrogen (ER), progesterone (PgR) and human epidermal growth factor receptor-2 (HER-2) receptors were considered in this evaluation. The results demonstrated that CXCL8, CXCL10 and CXCL16 showed a significant increased median in BC and BBL patients compared to control (CXCL8: 47.3 and 25.7 vs. 15.0; CXCL10: 37.6 and 30.7 vs. 13.1; CXCL16; 27.9 and 25.2 vs. 19.2 pg/ml, respectively). The increased levels of CXCL8 and CXCL16 were more pronounced in triple-negative and HER-2 positive patients, respectively. Binary logistic regression analysis revealed that CXCL8 was a significant predictor of BC, and such prediction was more depicted in triple-negative patients. The receiver operating characteristic analysis also revealed that CXCL8 recorded an area under curve of 0.998 in BC patients. In conclusion, CXCL8 is a potential biomarker for BC, especially when ER, PgR and HER-2 expression is considered. In this context, the predictive significance of CXCL8 in influencing BC progression is suggested in triple-negative patients.
سياسات الاصلاح النقدي في جمهورية الصين الشعبية
Affected by agricultural products in the Levant to a lot of factors that led to the rise in prices which as a result of natural factors, the most important and most notably the earthquakes that occurred in the dates of sporadic in the Levant,
السياسة الامريكية وحركة الاصلاح السياسي في السودان
تضمن هذا البحث علاقة التفسير الفقهي بالتفسير بالمأثور، وتبين أنها علاقة تلازم وترابط؛ لأنَّ الفقه هو استنباط الأحكام من أدلة الكتاب والسُّنة، وقد اعتنى بذلك المفسرون وشُرّاح الحديث، وكل واحدة منهما لا تتميز عن غيرها في الحاجة، ولا تستغني عنها في درك ما تنحوه من البغية والإرادة؛ ذاك لأنَّ الحديث بمنزلة الأساس الذي يعد الأصل، والفقه بمنزلة البناء الذي هو له كالفرع، وكل بناء لم يوضع على قاعدة وأساس فهو منهار،
... Show MorePraisebe to God, Lord of the worlds, and blessings and peace be upon the most honorable messengers, our Prophet Muhammad, may God bless him and granthim peace. And after
The method of request is one of the important rhetorical methods used by the creator in terms of rhetorical diversification, influence, artistic aesthetics and increasing textual coherence, and we tried through a group (Which torments are inferior) by the poet Majid Al-Rubaie, to shed light on these methods and their ability, displacement, relationality, direct and advertising interactions from them, and what they broadcast From metaphorical purposes is the second image of it, after its main image and title. This cohesion and harmony between the two images is an important and influential rhetorical trend.
المنظمات الدولية دراسة في منهجها وطبيعة فهمها
The semiotic approach to the unspoken seeks to analyze the text in an esoteric way, that is, to clarify what is hidden from it by reading between
Dans le romantisme et ses textes, il est important de mentionner qu'il n'existe qu'un seul thème romantique qui est l'amour, mais assez pour avoir fait du XIXème siècle, une révolution du texte romantique. L'amour consiste à la réduction de l'univers, à un seul être, puis la dilatation de ce seul être, voilà l'amour. cet amour passionnel n'est qu'un arrangement froid et réfléchi excluant d'emblée l'exaltation des sentiments. Néanmoins, cet amour passionnel peut être brutal. quant à la mort, dans le drame romantique, l'amour et la mort sont liés. Beaucoup d'histoires d'amour finissent le plus souvent par
... Show MoreIn this paper we will explain ,how use Bayesian procedure in analysis multiple linear regression model with missing data in variables X's as the new method suggest , and explain some of missing Patterns under missing mechanism , missing complete at random MCAR and compare Bayesian estimator with complete case estimator by use simulation procedure .