The biomarker significance of three chemokines (CXCL8, CXCL10 and CXCL16) was evaluated in sera of 45 breast cancer (BC) and 28 benign breast lesion (BBL) patients, as well as 20 control women. Clinical stage and tumor expression of estrogen (ER), progesterone (PgR) and human epidermal growth factor receptor-2 (HER-2) receptors were considered in this evaluation. The results demonstrated that CXCL8, CXCL10 and CXCL16 showed a significant increased median in BC and BBL patients compared to control (CXCL8: 47.3 and 25.7 vs. 15.0; CXCL10: 37.6 and 30.7 vs. 13.1; CXCL16; 27.9 and 25.2 vs. 19.2 pg/ml, respectively). The increased levels of CXCL8 and CXCL16 were more pronounced in triple-negative and HER-2 positive patients, respectively. Binary logistic regression analysis revealed that CXCL8 was a significant predictor of BC, and such prediction was more depicted in triple-negative patients. The receiver operating characteristic analysis also revealed that CXCL8 recorded an area under curve of 0.998 in BC patients. In conclusion, CXCL8 is a potential biomarker for BC, especially when ER, PgR and HER-2 expression is considered. In this context, the predictive significance of CXCL8 in influencing BC progression is suggested in triple-negative patients.
Chapter One – introduction
Nations managed today to achieve progress in the field of modern technology. Science has changed many beliefs and trendiness that people have held for long time, skills and scientific thinking developed, and made scientific observation and experiment replace narration and taking from others. That is attributed to examining the educational systems searching for the locations of defect, and shortage.
In the light of educational modernizations, many models of teaching incliuding a model for social tracing attributed to Herbart Thelen, which is a model to develop skills of social participation in the democratic process (Al-Khawalda,1993,335).
... Show Moreإمتاز ابن حجر بعلميته ، وغزارة عطائه في وضع كتب قيمة وتصانيف موسوعية فكانت كتبه هذه يشار لها بالبنان .
اعتنى الكثير من العلماء فاحتلت المرأة مكانة متميزة في كتبهم وخصصوا لمعطياتها أجزاء واضحة ضمن مؤلفاتهم ويعد أبن حجر أحد هؤلاء العلماء الافذاذ الذين اعتنوا بالمرأة ، وهذا يعني انه أفرد لها جزءاً خاصاً بها سماه ( كتاب النساء) وهو يقع ضمن الجزء الرابع من كتابه ، على الر
... Show MoreAnalytical Hierarchy Process (AHP) belongs to the family of Multiple Criteria Decision Making (MCDM) and has, recently, received a wide popularity in decision making regarding supplier selection. The objective of this study is to apply the methodology of AHP on selecting suppliers to supply materials for the Geological Survey and Mining Company (GSMC). Criteria for rating the suppliers and pairwise comparisons were identified by the members of the Tenders Analysis Committee (TAC). In order to judge the internal validity of the AHP, it was applied manually on a sample of fourteen tenders that were analyzed and executed between 2004-2007, then an interactive computerized package was developed
... Show Moreللدراسات التاريخية أهميتها ولاسيما دراسة المؤلفات الذي يعطينا صورة كاملة عن تطور الواقع التاريخي للمرحلة التي عاصرها المؤلف وتكتب دراسة الشخصيات العلمية طابعاً خاصاً ومهم يدفعنا إلى التعريف بالمؤرخ ومنهجه في الكتاب والموارد التي استقى معلوماتهِ منها .
The world witnessed variables influenced on entirely education essential mean to grantee the required adaption of inner and external motivations circumstances this gives us opportunity of the best selection means to achieve the goals for progress individual and community .
From here appeared the needs of scientific study interest in new styles of education locate the old place that become non able to granting students and their tendency n
... Show MoreThe research revolves around the methodology of the historian Ibn Wasil
(d.697 AH) in dealing with the Mongolian invasion through his book
“Mafrej al-Karroub fi Akhbar Bani Ayyub
The poet dependent formation of a caupillary to stimuli ,sensory based on the areas of cognition in cluding raises every sense in the mind of therecipient , taking advantage of the senses which help him to perception and imagination and photography .i wanted in my Research that showed silent in the poetry of muslim Ibn al walid by the method of use the senses and then method of imaging divided the research to the axes according to topics hair began to praise ,I have found through mating poetic image with silent about the poet in the purpose of praise that he wanted . the caliphate of yazidI bnmazidknignt courageous , and thisis found in the clear signals in the poems silent poet what he wanting saying . The purpose that I choose to look out
... Show MoreThis study Concentrates on modern variable in the human resources management that is Core Competency.
The field study is two of Public organizations, The first is Educational Baghdad Hospital, the other is the state Company for Batteries industry, the problem of the study determincs some questions and hypotheses. The data was Collected by questionnaire which Contains six Core Competences leader ship, Communication, frontline execution, development, innovation and self management .
The sample contains (26) doctores and (28) heads of departments in the company.
The study points out many conclusions, the main of it, there is significant differences amon
... Show Moreشيد الفكر العربي المعاصر تحولات عدة فرضتها بعض التيارات الفكرية والفلسفية الغربية، وأثرت في تكوينه وتحديد اتجاهاته، فضلا عن التحديات التي بات لزاما عليه ان يتعامل معها ويمكن رد هذه التحديات الى عدة عوامل داخلية وخارجية أنتجت عدة تيارات تناولت موضوع العقلانية في الفكر العربي المعاصر، لعل أبرزها التيار الاصلاحي، التيار الليبرالي، والتيار العقلي النقدي
The physician's commitment to medical insight is affected by several factors that vary from patient to patient in terms of the nature of the disease, the severity of the disease, the age of the patient, and the purpose of undergoing medical intervention. There are circumstances surrounding patients that require the physician to reduce the insight towards them, by concealing medical information. The physician must firmly commit to expanding the scope of his vision to a wider extent than in normal medical work. Therefore, we will discuss in this regard the cases in which medical explanation is reduced and the cases that require confirmation in the following order.