The biomarker significance of three chemokines (CXCL8, CXCL10 and CXCL16) was evaluated in sera of 45 breast cancer (BC) and 28 benign breast lesion (BBL) patients, as well as 20 control women. Clinical stage and tumor expression of estrogen (ER), progesterone (PgR) and human epidermal growth factor receptor-2 (HER-2) receptors were considered in this evaluation. The results demonstrated that CXCL8, CXCL10 and CXCL16 showed a significant increased median in BC and BBL patients compared to control (CXCL8: 47.3 and 25.7 vs. 15.0; CXCL10: 37.6 and 30.7 vs. 13.1; CXCL16; 27.9 and 25.2 vs. 19.2 pg/ml, respectively). The increased levels of CXCL8 and CXCL16 were more pronounced in triple-negative and HER-2 positive patients, respectively. Binary logistic regression analysis revealed that CXCL8 was a significant predictor of BC, and such prediction was more depicted in triple-negative patients. The receiver operating characteristic analysis also revealed that CXCL8 recorded an area under curve of 0.998 in BC patients. In conclusion, CXCL8 is a potential biomarker for BC, especially when ER, PgR and HER-2 expression is considered. In this context, the predictive significance of CXCL8 in influencing BC progression is suggested in triple-negative patients.
هدف هذا البحث الى التعرف على أثر فاعلية تكنولوجيا التحول الرقمي في تحسين كفاءة الخدمة التأمينية في شركات التأمين العامة في العراق من خالل تكنولوجيا التحول الرقمي في العملية التأمينية "الترويج لمنتج التأمين,تقديم طلب التأمين,االكتتاب ,تسوية الخسائر" ولتحقيق هذا الهدف تم تصميم استمارة استقصاء وزعت في المجتمع المبحوث والتي تمثل متخذي القرار في الشركات المبحوثة قيد البحث وكان من اهم نتائج البحث وجود عالقة بين ا
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Due to increased interest on organizations and the human element, organizational and environmental aspects of the organization Has been analyzed, and behavioral aspects of the members and what is the impact of each on the other, To give the recipe interaction between the organization and its environment, in order to bring about change in behavior appeared the concept of organizational health as a concept in a modern organizations, Either the organization to be stimulating good, healthy, and then called healthy organization Or that the situation be frustrating it is not good and unhealthy, so the cause of tension and anxiety, unhealthy organization is here The research aim to determine the existence of organizatio
... Show Moreيُعدّ الوجود احد أعمق المواضيع التي تناولها الفلاسفة على مرّ العصور، إذ يشتمل على تساؤلات حول الحياة والموت وغاية الوجود والحرية الإنسانية، وغيرها من التساؤلات التي نشأت مع نشوء الانسان. وقد لعب الفلاسفة، قديمهم وحديثهم، دورًا أساسيًا في إرساء دعائم الفكر الوجودي المعاصر؛ إلا أننا, مع ذلك, لا نستطيع إنكار دور الدين في التأثير على الفكر الفلسفي الوجودي بشكل عام. وقد انعكست أفكار الوجودية الفلسفية المعاصرة في
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لاحظ الباحث عن طريق خبرته – المتواضعة- في أثناء عمله في ميدان التدريس في أقسام القرآن الكريم والتربية الإسلامية ان هناك ضعفاً في المستويات وتدنياً واضحاً في التفكير المنظومي للطلبة في مادة الإعجاز القرآني، ويرى الباحث أن هذا التدني يعود إلى أسباب عديدة من أبرزها: طرائق تدريس المادة، وغزارة المادة الدراسية، وصعوبة استيعابها في الوقت القصير المخصص لها، وان
... Show MoreThe present study aimed to impact Strategy mental map in the acquisition of geographical concepts at the fifth-grade students in the literary geography classes. To achieve the objectives of the research formulated researcher null hypothesis (no statistically significant difference at the level (0.05) between the average scores of students who Adersna using a mind map, and who Adersna using the method usual in the acquisition of concepts geographic fifth grade literary). Has chosen researcher design Altjeribeachtar researcher Design The partial adjustment for both experimental and control groups Pachtearlakedzab concepts. The sample Seateetmthel graders secondary schools under the Directorate General of Educational Baghdad Rusafa II has c
... Show MoreSeeks this research is to clarify the role played by TQM represented Bmngaradtha (commitment and support of senior management of the philosophy of TQM, strategic planning for the overall quality, focus on the customer, continuous improvement, post workers, training and rehabilitation of workers) to achieve sustainable competitive advantage represented by dimensions (estimated intrinsic , creative culture, information technology, strategic flexibility), research has relied on the views of a sample of managers working in the Iraqi public insurance company. So identified research problem in answering the following questions: "What is the size of visualization owned by managers in the co
... Show MoreThe Costing Accounting is one the analytic tools which plays important role by support the management in planning& control and decisions-making ,as it became attendant necessity to establish any project whether industrial ,commercial ,service or agriculture ..etc.
The consolidated accounting system has committed the companies to have their active costing system in which the management can obtain their own data, but we found most of the economic units face problems of applying the costing system because of reasons related to the system design itself or might be related to the requirements of the application success.
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