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The key role of RANKL and OPG as molecular biomarkers in bone remodeling associated with different grafts regarding socket preservation: A systematic review
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Objectives: Bone remodeling usually depends on complex molecular signaling, where receptor activator of NF-B ligand (RANKL) and osteoprotegerin (OPG) serve as key modulators that regulate osteoclastogenesis and overall bone metabolism process. This systematic review aimed to evaluate the influence of different graft materials on RANKL and OPG expression following alveolar ridge preservation. Methods: An electronic search of the literature was performed in Embase via Ovid, Medline via Ovid, CINAHL, Scopus and Web of Science databases, in addition to a manual search regarding all related articles. PRISMA guidelines and PICO framework were followed in this systematic review. The inclusion criteria were limited to English-published studies focusing on RANKL and/or OPG biomarkers’ outcomes in post-extraction dental sockets preserved with various types of bone grafts. The extracted data were synthesized in a standardized excel form including general study characteristics, graft interventional details, and RANKL/OPG expressions in addition to other outcomes regarding bone healing. Risk of bias, using ROBINS-I and RYRCLE tools, as well as certainty of evidence were assessed within included studies. Results: The initial search resulted in a total of 307 articles. After thorough screening and reviewing stages, 12 studies were finally selected to be included for comprehensive analysis. The findings revealed that socket preservation with different grafts demonstrated statistically significant differences in favor of RANKL downregulation and OPG upregulation compared to controls; the composite graft demonstrated superior outcomes to other types. The lowest RANKL/OPG ratio (0.11) was reported in the biologically enhanced autograft while synthetic graft alone showed the highest value (1.88). Conclusion: Bone substitutes that combine bioactive agents with scaffolds may offer potential benefits for socket preservation, possibly through modulation of the RANKL/OPG axis. However, their superiority over other grafts and the reliability of the RANKL/OPG ratio as a predictive biomarker remain uncertain, warranting further clinical investigation.

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Publication Date
Sat Jul 08 2023
Journal Name
Al-nahrain Journal For Engineering Sciences
The Influence of Using Recycled Asphalt Pavement and Crumbed Rubber on Asphalt Pavement: A Review
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Reclaimed (recycled) asphalt pavement (RAP), the most recycled material worldwide, is the mostly reclaimed material utilized in hot mix asphalt. Polymer (Crumb rubber) incorporation frequently leads to enhanced durability and resistance to heat cracking and rutting, two forms of permanent deformation. It also relieves stiffness and minimizes fatigue damage. This study aims to gather all previous RAP-related research and crumb rubber CR, so that the impact of using these materials on mechanical, physical properties of asphalt pavement, environmental effect and cost effective are clarify and explained. The finding of this research proved that the use of RAP and CR provide considerable structural and financial enhancements to the const

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Publication Date
Sun Dec 01 2019
Journal Name
Saudi Medical Journal
The diagnostic power of circulating micro ribonucleic acid 34a in combination with cancer antigen 15-3 as a potential biomarker of breast cancer
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Publication Date
Sat Jun 01 2024
Journal Name
Journal Of Research In Dental And Maxillofacial Sciences
Relationship between Third Molar Impaction and Extraction, and Awareness about the Associated Potential Risks
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Publication Date
Wed Apr 01 2026
Journal Name
كلية العلوم السياسية / جامعة الموصل / مؤتمرها العلمي الدولي الخامس والسنوي
The state's Orientation towards using sustainable electrical energy with the contribution of Artificial Intelligence (AI) / Geothermal energy As a model / contributes to strengthening the building of a future the state's strength "A study in political geography"
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المستخلص: هناك مشكلة تعاني منها الدولة وهي الأعتماد على الطاقات التقليدية الملوثة Abstract: The country suffers from a problem which is the reliance on traditional polluting and non-renewable energies and the failure to discover and exploit sustainable sources such as geothermal energy. The research hypothesis is whether the modern state’s orientation towards exploiting a modern energy source such as geothermal energy contributes in some way to achieving another source of energy and benefiting from it to enhance the building of a new type of state power from buried energy sources? And does artificial intelligence technology contribute to solving a specific problem by exp

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Publication Date
Sun Apr 30 2017
Journal Name
Journal Of Engineering
Experimental Study on Heat Transfer and Friction Factor Characteristics of Single Layer Graphene Based DI-water Nanofluid in a Circular Tube under Laminar Flow and Different Heat Fluxes as Boundary Conditions
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An experimental study was performed to estimate the forced convection heat transfer performance and the pressure drop of a single layer graphene (GNPs) based DI-water nanofluid in a circular tube under a laminar flow and a uniform heat flux boundary conditions. The viscosity and thermal conductivity of nanofluid at weight concentrations of (0.1 to 1 wt%) were measured. The effects of the velocity of flow, heat flux and nanoparticle weight concentrations on the  enhancement of the heat transfer are examined. The Nusselt number of the GNPs nanofluid was enhanced as the heat flux and the velocity of flow rate  increased, and the maximum Nusselt number  ratio (Nu nanofluid/ Nu base fluid)   and thermal performance factor

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Publication Date
Sun Dec 02 2018
Journal Name
Journal Of The College Of Education For Women
The Role of Local Satellite Channels in the formation of knowledge and trends of the Iraqi Public Towards Terrorism: A Field Study
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Terrorism is a global phenomenon that engulfs most regions of the world to varying degrees. Media outlets are aware of the many incidents of violence and terrorism that have increased in recent times. The differences between the size of the phenomenon in different societies are the causes and severity of the phenomenon. On the role of local satellite channels in shaping the knowledge and trends of the Iraqi public towards the events of terrorism, in light of the assumptions of reliance on the media. The importance of this study is that it assesses the role of local satellite channels in the formation of knowledge and trends The study seeks to know the extent of exposure of the Iraqi public to local satellite channels, and to reveal the e

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Publication Date
Tue Jun 01 2021
Journal Name
Political Sciences Journal
The European Union and the Extremist Right Phenomenon: Brexit as a Model
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The European Unit has never been affected by a serious phenomena as the phenomena of the advancing of the far right parties. Though these parties vary in their impact in their original countries, they agree on one important issue which is the deconstruction of the European unit and limiting its supernational powers. These increasing popular parties aim at more national independence in decision making away from the decisions taken by Brussels. Moreover, they criticize the financial and administrative corruption accompanied many of the rescuing procedures directed for example towards countries like Greece and Spain during the international economic crisis. This failure nourishes many of the negative feelings against the European unit which

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Publication Date
Mon Jan 01 2024
Journal Name
Aims Energy
The impact of different compression ratios on emissions, and combustion characteristics of a biodiesel engine
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<p>The current work investigated the combustion efficiency of biodiesel engines under diverse ratios of compression (15.5, 16.5, 17.5, and 18.5) and different biodiesel fuels produced from apricot oil, papaya oil, sunflower oil, and tomato seed oil. The combustion process of the biodiesel fuel inside the engine was simulated utilizing ANSYS Fluent v16 (CFD). On AV1 diesel engines (Kirloskar), numerical simulations were conducted at 1500 rpm. The outcomes of the simulation demonstrated that increasing the compression ratio (CR) led to increased peak temperature and pressures in the combustion chamber, as well as elevated levels of CO<sub>2</sub> and NO mass fractions and decreased CO emission values un

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Publication Date
Mon Jul 01 2024
Journal Name
Journal Of The Faculty Of Medicine Baghdad
Serum CXCL 9 as a Potential Biomarker for Patients with Ulcerative Colitis
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Background: Ulcerative colitis (UC) is an inflammatory bowel disease restricted to the large intestine, characterized by superficial ulceration. It is a progressive and chronic disease requiring long-term treatment. Although its etiology remains unknown, it is suggested that environmental factors influence genetically susceptible individuals, leading to the onset of the disease. (C-X-C) ligand 9 is a chemokine that belongs to the CXC chemokine family, it plays a role in the differentiation of immune cells such as cytotoxic lymphocytes, natural killer T cells, and macrophages. Its interaction with its corresponding receptor CXCR3 which is expressed by a variety of cells such as effector T cells, CD8+ cytotoxic T cells, and macrophage

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Publication Date
Fri Feb 08 2019
Journal Name
Journal Of The College Of Education For Women
Problematic intervention in the new international order and its impact on international relations - the U.S. role a model
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Intervention in International Relations from the concepts that are still highly
controversial among those he considers a breach of international law and the UN Charter and
in violation of the rule , and those who felt that the need provided, however, that this is linked
motives humanity recognized by the international community , because the international
variables proved the inadequacy of the principle of non-interference and the principle of
sovereignty as the traditional variables international , and therefore most of the international
practice came a bus with many of the behaviors that reflect a decline in its entirety to these
principles , and became adapt these principles with international reality is too compl

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