Poorly soluble drugs are often a challenge in product formulation. Generally, low aqueous solubility and poor bioavailability of drugs have restricted their application in various fields. Nanosuspensions enhance the solubility and bioavailability of poorly water-soluble drugs. Curcumin, a hydrophobic polyphenol, exhibits poor aqueous solubility (<1 μg/mL), and formulating it as nanosuspension can enhance its solubility. However, the optimal selection of preparation technique, solvent, stabilizer, and drug-to-stabilizer ratio is critical for formulation success for a successful formulation. This work aims to optimize the preparation process of Curcumin nanosuspension. In addition, it aims in screening of the effectiveness of different stabilizers, solvents, and ratios of drug to stabilizers. Stabilizers tested included polymers (e.g., PVP30, HPMC) and surfactants (e.g., Tween 40, Poloxamer 407) in varying proportions of drug-to-stabilizer ratios were tried to choose the best stabilizer. Solvents were used as a mixture of acetone and ethanol or as a sole solvent, ethanol alone. The preparation of Curcumin (CRN) nanosuspension was accomplished by the solvent-antisolvent method using three different techniques: magnetic stirring, ultra-sonication bath, and ultra-sonication probe. Optimization of the selected formula was established by determination of particle size, polydispersity index, and zeta potential. In addition, the investigations included measurement of entrapment efficiency, CRN loading and pH. Stability test was conducted on Curcumin nanosuspension (the selected formula) over 2 months at 25˚C and 4˚C. Concerning the solvent, ethanol as a sole solvent was better than the acetone-ethanol mixture. Magnetic stirring yielded better results than ultra-sonication methods. The best nanosuspension formula, CRN-24, was prepared using Polyvinylpyrrolidone K30 (PVP30) at a 1:2 drug-to-stabilizer ratio with magnetic stirring and ethanol as the solvent. CRN-24 exhibited a particle size of 53.42 nm, PDI of 0.18, zeta potential of -15.21 mV, entrapment efficiency of 41.12%, and drug loading of 87.19%. Stability tests showed acceptable stability at 4˚C. The main conclusion of this study is that optimal solvent, stabilizer, and drug-to-stabilizer ratio are essential for stable curcumin nanosuspensions
The study aims (objective ) to clarify the concept of comprehensive income and its usefulness for users, as the study aims to clarify the relationship between the concept of comprehensive income and market value of the company where the measurement of comprehensive income after accounting for net income and by measuring the unrealized gains or losses in the value of securities available for sale, and measurement the unrealized gains or losses on futures contracts, which are financial derivatives, and measurement the unrealized gains or losses from the settlement of foreign currency translation (conversions), and measurement the impact on the market value of companies and of the present study to rise or fall of return on the stock
... Show MoreAmid the growing demand for multifunctional and environmentally benign materials, lead-free double perovskites have emerged as a strategically important development in advanced functional materials research. This study presents the synthesis of Ba2PrMnO6 (BPMO) double perovskite nanocrystals for the first time via a hydrothermal method, and a comprehensive evaluation has been conducted using the density functional theory (DFT) framework. Structural, thermodynamic, electronic, optical, and mechanical properties were investigated through X-ray diffraction (XRD), ultraviolet-visible (UV-vis) spectroscopy, FESEM/EDX, FTIR, and density functional theory (DFT) calculations. XRD confirms a stable tetragonal I4/m phase with experimental lattice con
... Show MoreThe critical micelle concentration (CMC) of nonylphenolethoxylate (NPE) surfactant has been determined by measuring the surface tension as a function of the molar concentration of the surfactant in aqueous and binary mixture of water + methanol solutions at a temperature range from 20?C to 35?C. The interfacial parameters ?max, Amin, ?cmc and ?G?ads were calculated. The results indicate that the CMC increases as the temperature increases and that the addition of methanol the CMC decreases. The thermodynamic parameters such as standard Gibbs free energy (?G?), enthalpy (?H?), and entropy (?S?) of micellization were estimated using the change of CMC with temperature. The enthalpy – entropy compensation behavior of the surfactant was evaluat
... Show MoreIn this paper, various aspects of smart grids are described. These aspects include the components of smart grids, the detailed functions of the smart energy meters within the smart grids and their effects on increasing the awareness, the advantages and disadvantages of smart grids, and the requirements of utilizing smart grids. To put some light on the difference between smart grids and traditional utility grids, some aspects of the traditional utility grids are covered in this paper as well.
Processing sulfur containing minerals is one of the biggest sources of acute anthropogenic pollution particularly in the form of acid mine drainage.