Poorly soluble drugs are often a challenge in product formulation. Generally, low aqueous solubility and poor bioavailability of drugs have restricted their application in various fields. Nanosuspensions enhance the solubility and bioavailability of poorly water-soluble drugs. Curcumin, a hydrophobic polyphenol, exhibits poor aqueous solubility (<1 μg/mL), and formulating it as nanosuspension can enhance its solubility. However, the optimal selection of preparation technique, solvent, stabilizer, and drug-to-stabilizer ratio is critical for formulation success for a successful formulation. This work aims to optimize the preparation process of Curcumin nanosuspension. In addition, it aims in screening of the effectiveness of different stabilizers, solvents, and ratios of drug to stabilizers. Stabilizers tested included polymers (e.g., PVP30, HPMC) and surfactants (e.g., Tween 40, Poloxamer 407) in varying proportions of drug-to-stabilizer ratios were tried to choose the best stabilizer. Solvents were used as a mixture of acetone and ethanol or as a sole solvent, ethanol alone. The preparation of Curcumin (CRN) nanosuspension was accomplished by the solvent-antisolvent method using three different techniques: magnetic stirring, ultra-sonication bath, and ultra-sonication probe. Optimization of the selected formula was established by determination of particle size, polydispersity index, and zeta potential. In addition, the investigations included measurement of entrapment efficiency, CRN loading and pH. Stability test was conducted on Curcumin nanosuspension (the selected formula) over 2 months at 25˚C and 4˚C. Concerning the solvent, ethanol as a sole solvent was better than the acetone-ethanol mixture. Magnetic stirring yielded better results than ultra-sonication methods. The best nanosuspension formula, CRN-24, was prepared using Polyvinylpyrrolidone K30 (PVP30) at a 1:2 drug-to-stabilizer ratio with magnetic stirring and ethanol as the solvent. CRN-24 exhibited a particle size of 53.42 nm, PDI of 0.18, zeta potential of -15.21 mV, entrapment efficiency of 41.12%, and drug loading of 87.19%. Stability tests showed acceptable stability at 4˚C. The main conclusion of this study is that optimal solvent, stabilizer, and drug-to-stabilizer ratio are essential for stable curcumin nanosuspensions
This study aimed to study the inhibition activity of purified bacteriocin produced from the local isolation Lactococcuslactis ssp. lactis against pathogenic bacteria species isolated from clinical samples in some hospitals Baghdad city. Screening of L. lactis ssp. Lactis and isolated from the intestines fish and raw milk was performed in well diffusion method. The results showed that L. lactis ssp. lactis (Lc4) was the most efficient isolate in producing the bacteriocin as well observed inhibitory activity the increased that companied with the concentration, the concentration of the twice filtrate was better in obtaining higher inhibition diameters compared to the one-fold concentration. The concentrate
... Show MoreThe existing investigation explains the consequence of irradiation of violet laser on the structure properties of MawsoniteCu6Fe2SnS8 [CFTS] thin films. The film was equipped by the utilization of semi-computerized spray pyrolysis technique (SCSPT), it is the first time that this technique is used in the preparation and irradiation using a laser. when the received films were processed by continuous red laser (700 nm) with power (>1000mW) for different laser irradiation time using different number of times a laser scan (0, 6, 9, 12, 15 and 18 times) with total irradiation time (0,30,45,60,75,90 min) respectively at room temperature.. The XRD diffraction gave polycrysta
... Show MoreSami Michael and Eli Amir - two Israeli writers born in Iraq and of the same generation (Sami Makhail was born in Baghdad in 1926 and Eli Amir in 1937). They wrote in their novels, among other things, about Orientalism , love and femininity. They both lived wild, extroverted lives. They did not shy away from experiencing anything new that came their way, rebelled against conventions and acted provocatively; they enjoyed the shock and amazement that evoked around them. While trying to find their place in different family settings, they chose to present two Arab Christian heroines. The narrator in Jasmine is the speaker Noori-Eli himself. While the narrator of “Trumpet in the Wadi” is Huda the heroine herself. Both ar
... Show MoreIn this article four samples of HgBa2Ca2Cu2.4Ag0.6O8+δ were prepared and irradiated with different doses of gamma radiation 6, 8 and 10 Mrad. The effects of gamma irradiation on structure of HgBa2Ca2Cu2.4Ag0.6O8+δ samples were characterized using X-ray diffraction. It was concluded that there effect on structure by gamma irradiation. Scherrer, crystallization, and Williamson equations were applied based on the X-ray diffraction diagram and for all gamma doses, to calculate crystal size, strain, and degree of crystallinity. I
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