هاله عبد الرحمن إبراهيم خلف
-
Halah, A. R. Ibrahim
MSc
-
assistant lecturer
College of Engineering
,
Petroleum engineering department
[email protected]
Publication Date
Wed Jul 01 2020
Journal Name
International Journal Of Pharmaceutical Research
(2)
(1)
Publication Date
Sat Apr 04 2020
Journal Name
Biochemical And Cellular Archives
Publication Date
Thu Apr 29 2021
Synthesis and Identification of Some New Derivatives of ([Benzyl Thio) Benzimidazole -N- (Methylene-5-Yl)] - 4,5- Di Substituted 1,2,4-Triazole and Evaluation of Their Activity as Antimicrobial and Anti-Inflammatory Agents
2-Mercaptobenzimidazole
semicarbazide
thiosemicarbazide
phenylsemicarbazide 1
2
4-triazole
Anti-Microbial
Anti-inflammatory
New 2-Mercaptobenzimidazole derivatives were synthesized. 4,5-disubsitituted 1,2,4-Triazole compounds 1b-2c were synthesized from 2-(benzylthio) benzimidazole compound a, which was then reacted with (NaH) in dioxane at a temperature of (0-5 C°) to produce the salt of compound a. Then the salt was reacted with ethyl chloro acetate to yield Ethyl 2-(benzylthio) benzimidazole acetate compound b. Compound b was converted to triazole derivatives by two pathways. The first pathway was reacting compound b with semicarbazide, thiosemicarbazide and phenylsemicarbazide in DMSO as a solvent to gain compounds 1b-3b, which were then
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