Multiple sclerosis (MS) is a chronic, inflammatory demyelinating disease of central nervous system with complex etiopathogenesis that impacts young adults (Lee et al., 2015), and MS impacts younger and middle aged character and leads to a range of disabilities that can alter their daily routines (Yara et al, 2010). Although, the exact cause of MS is still undetermined, the disease is mediated by adaptive immunity through the infiltration of T cells into the central nervous system (Bjelobaba et al, 2017). MS causes the Focal neurological symptomsand biochemical changes in the molecular level and the variation of neural cells such as loss or alteration of sensation, motor function, visible signs such as blurred vision or transient blindness, disturbance of conjugate eye movements, bladder and bowel dysfunction and cognitive impairment (Induruwa et al, 2012 and Jafarzadeh et al, 2014). Autoimmune diseases (ADs) are chronic conditions initiated by way of the loss of immunological tolerance to self-antigens (TodorovicDilas et al, 2011). It is a heterogeneous group of disorders in which more than one modification in the immune system can be specific to a particular tissue or organ or might also be systemic, non-specific, involving multiple tissues or organs (Ray et al, 2012). One possible cause behind this is a lack of understanding of pathogenic mechanisms driving progressive multiple sclerosis. Due to the indolent nature of symptom progression, current disease criteria used to signify the course of disease (Lublin et al, 2014) indicate diagnosis is generally retrospective and based totally on history of gradual worsening. Clearly, diagnosis is primary based on clinical judgment, as there is no fully reliable diagnostic test (Ontaneda et al, 2015). In latest years, the elements involved in the etiology of the disease have also included oxidative stress (OS), which is described as an imbalance between the generation of reactive oxygen species (ROS) and the mechanisms that are responsible for their elimination, andthe imbalance between OS agents and antioxidants leads to OS activating the inflammatory process (Phaniendra et al, 2015). In the absence of enough antioxidant defenses, ROS can reason oxidative damage to macromolecules resulting in oxidation of lipids, proteins and deoxyribonucleic acid (DNA) (Griffiths, 2002). Some reseach report that ROS play a main role in myelin phagocytosis (Ghabaee et al, 2010 and Tasset et al, 2012). The inflammatory response gives rise to the manufacturing of both ROS and Reactive Biochem. Cell. Arch. Vol. 19, No. 1, pp. 31-35, 2019 www.connectjournals.com/bca ISSN 0972-5075 Nitrogen Species RNS through monocyte interactions with brain endothelium; ROS manufacturing induces cytoskeletal rearrangements, loss of blood-brain blood BBB integrity, tight-junction alteration and the extravasation of leukocytes into the central nervous system (Van et al, 2011; Witherick et al, 2011). Aim of study The aim of this study focuses on determination 8-H2-dG, MDA and PON1 in multiple sclerosis disease and finds the relationship between newly marker 8-H-2-dG with MDA and PON1. MATERIALS AND METHODS Subjects This study was performed on 25 female patients with age (25-35) years who diagnosed by physicians as a multiple sclerosis in Misan governorate. The patients compared with 25 apparently healthful in the identic rangel of age. In this study sample was collected five mL of venous bloods, placed in to plain tubes until coagulation was performed. Serum was separated from blood cells by centrifugation 4000 r.p.m. Assay method Determination of serum of 8-H-2-dG This assay that can be used for quantification of 8- H-2-dG in urine, cell culture, plasma and other sample matrices. The ELISA utilize an 8-H-2-dG coated plate and HRP- conjugated antibody or detection which allows for any assay range of 0.94-60 ng/mL, with sensitivity of 0.59 ng/mL. Determination of MDA The concentration of MDA,which is the consequence of lipid peroxidation and a marker of oxidative stress, was measured using thiobarbiturc acid. Determination of PON1 The quantitive sandwich enzyme immunoassay (ELISA) technique was employed for determination of PON1.
Is the efficiency of physical and your endurance is of great importance for some activities and field, as it whenever the situation has improved student career was able to perform physical exertion more with energy saving efforts, so the identification of physical aptitude and endurance private students, was based on that there are positively correlated the carrying of training and pregnancy fact on the shoulders of the student. In other words, physical aptitude and endurance in your control level that can be shown by the student during the performance of training and competitions. Therefore, lies the importance of research to test physical aptitude and endurance your help to reveal the career of the body in the light of their relationship
... Show MoreObjectives: The study objectives are to determine the impact of education program upon the academic nurses'
practice concerning documentation of nursing sheets, and to find out the relationship between nurses knowledge
and their demographic characteristics, which include age, sex, and years of experience in medical and surgical
wards.
Methodology: A quasi- experimental study was carried out at the medical and surgical wards in teaching
hospitals in Sulaimani governorate from the beginning of March up to June 2007٠
To reach the objectives of the study anon-probability (purposive) sample of (25) academic nurses who work in
the medical and surgical wards in teaching hospitals.
The data were collected through the use
Abstract
Prais be to Allah the Lord of the Worlds and prayers and peace be upon our faithfull Prophet …. I wrote this Research entitled (The Imam Shams AL-din Abdulrahman Bin Qudamah AL-Maqdsi (died: 682 A.H) Slections in Slections in proving contract annulment choice (AL-tassriah)and its duration which Iclarrified the reason of choosing this title and my method in writing Morever, a brief Overriew of the life of Imam Shams AL-din Bin Qudamah and the meaning of (AL-tassriah)and whether it proves to the buyer to return it, beside the duration which (the tassriah) proven, and a conclusion in which I showed the results I reached and some recommendations that some researchers in the field of Jurispruden
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The author addresses the issue of the linguoculturological component in the process of teaching Russian to Arabic students, focuses on the peculiarities of the national character of students. The author also refers to the long-standing ties of Russian and Arab cultures, thus emphasizing the relevance of this aspect for the current state and situation of the Russian language in Arab countries.
Автор статьи обращается к вопросу лингвокультурологической составляющей в процессе преподавания русского языка арабским студентам, останавливается на особенностях национального хара
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(16)
The research aims to know The Effect Of Flexible Grouping Strategy and Three Step Interview strategy on achievement of the history material among student of the first literary class, The Researcher used the experimental design of the two experimental groups and the control group and with post test, researcher group (a) represent the experimental group taught according the Flexible Grouping Strategy , and Division (c) to represent the second experimental group which studied according Three Step Interview strategy and Division (b ) to represent the control group taught in the traditional method, the number of students (99) students of (33) female students in each division. T
... Show MoreThis study was carried out at the Poultry Research Station belong to state Board of Agricultural Research, Ministry of Agriculture, Abu Ghraib. The duration of this study was from 28 November 2013 to 15 May 2014 to evaluate the effect of supplementation different levels of organic selenium(Se-yeast) and inorganic selenium (Selenium selenite) on some productive performances of broiler breeder and selenium levels in plasma ,egg (yolk,albumin). The study included 336 female broiler breeder and 28 males (Ross 308 and arbor acres), 42 weeks old were randomly distributed to 7 dietary treatments experiment with 2 replicates / treatment (24 females and 2 male birds /replicate). The duration of the experiment was 24 weeks, and treatments were as the
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Background: The demand for esthetic orthodontic appliances is increasing; so the esthetic orthodontic archwires were introduced. Among them, Teflon and Epoxy coated stainless steel archwires. The amount of force available from the archwire depends on the structural properties and susceptibility to corrosion. All metallic alloys are changed during immersion in artificial saliva, chlorhexidine mouthwash andtoothpaste, but their behaviors differ from one type to another. They corrode at different rates, which lead to decrease the amount of force applied to the teeth. This in vitro study was designed to evaluate the corrosion pits in stainless steel archwires coated with Teflon and with Epoxy in dry and after immersion in artificial saliva, chl
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(1)
The dynamic thermomechanical properties, sealing ability, and voids formation of an experimental obturation hydroxyapatite-reinforced polyethylene (HA/PE) composite/carrier system were investigated and compared with those of a commercial system [GuttaCore (GC)]. The HA/PE system was specifically designed using a melt-extrusion process. The viscoelastic properties of HA/PE were determined using a dynamic thermomechanical analyser. Human single-rooted teeth were endodontically instrumented and obturated using HA/PE or GC systems, and then sealing ability was assessed using a fluid filtration system. In addition, micro-computed tomography (μCT) was used to quantify apparent voids within the root-canal space. The data were statistically analys
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(7)
Background: The anterior loop of mental nerve is commonly described as that part of the neurovascular bundle that transverses anterior and inferior to the mental foramen only to loop back to exit the mental foramen. The aim of the study is to evaluate the incidence and extension of anterior loop of mental nerve by using digital panoramic imaging system to avoid nerve damage during different surgical procedures in dentistry. Materials and Method: Panoramic image was taken for all 400 patients and stored in the computer. Then Horizontal and Vertical for the anterior loop extension when exist was measured and recorded in a special case sheet prepared for each subject. Results: Results indicated that out of 400 patients there were only 25 pat
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