العقم هو أحد المشاكل التي تواجه النساء والرجال. تعد السمنة واضطرابات مستوى الدهون، وكذلك مقاومة الأنسولين، من عوامل الخطر التي تسبب العقم، بالإضافة إلى العوامل الأخرى ذات الصلة. تهدف هذه الدراسة إلى معرفة تأثير السمنة واختلال توازن الدهون مع دراسة علاقة كل من ثنائي الببتيديل ببتيديز-4 وعامل نخر الورم-الفا لدى النساء المصابات بالعقم مقارنة بالنساء غير المصابات به، لتحديد مدى إمكانية اعتمادها كعوامل تشخيصية ودالة على المرض. شملت الدراسة 50 مشاركاً، الفئة العمرية (15-34) سنة، الذين راجعوا مستشفى كمال السامرائي في بغداد، العراق. تم تقسيم المشاركين إلى مجموعتين؛ مجموعة المرضى (30 امرأة تعاني من العقم) ومجموعة السيطرة (20 امرأة سليمة). تم تقييم مستويات FBS، وانماط الدهون، وDPP4، وTNF-α، وFSH، وLH، والأنسولين والتستوستيرون. وتم تحديد مستويات FBS والدهون على أساس الطرق الطيفية. و تقدير مستويات DPP4 وTNF-α وFSH وLH والأنسولين والتستوستيرون بواسطة كتات ELISA الخاصة بهم. تم حساب مؤشر كتلة الجسم، HOMO-IR، ومؤشر تصلب الشرايين. أظهرت النتائج ارتفاع مستويات FBS، الدهون (باستثناء HDL)، DPP-4، TNF-α، LH، التستوستيرون وانخفاض مستوى هرمون FSH لدى المرضى مقارنة بالنساء الأصحاء. تؤكد زيادة قيم مستويات الدهون ومؤشر تصلب الشرايين ومقاومة الأنسولين ارتباط العقم بالسمنة واضطرابات الدهون والسكري وتصلب الشرايين. علاوة على ذلك، فإن DPP-4 وTNF-α مفيدان كعوامل تشخيصية جيدة للعقم عند النساء.
Placenta previa refers to placenta which is totally or partly implanted in lower segment of the uterus. Mortality and morbidity of mother increase with placenta previa due to the increase in the incidence of bleeding during pregnancy. This study aims to define placenta previa prevalence among pregnant women at AL-Fallujah teaching hospital and to determine the risk factors and their association with placenta previa incidence in al-Fallujah city population. This retrospective cohort study investigated medical registry of 6339 gravid women in al-Fallujah teaching Hospital in Iraq. We find 13 cases of placenta previa (0.21%) amongst the 6339 cases registered. The risk factors that strongly appeared to affect the complication of pregnancy with
... Show MoreAs a well-known oral and intravenous antifungal, voriconazole (VRN) has an extensive history of usage in the medical field. Solid lipid nanoparticles (SLNs) have been produced to treat ocular fungal keratitis in the eye. A 32Box-behnken design was used to produce a variety of new formulas for hot-melt extrusion. The SLNs were evaluated by entrapment efficiency (EE percent), particle size (PS), polydispersity index (PDI), and zeta potential (ZP). A series of in-vitro and in-vivo studies were carried out on the new formula. The produced vesicles’ EE, PS, PDI, and ZP values were all good. SLNs eye drops were numerically adjusted to include carbopol, a stabilizer, lipids, and a surfactant, among other substances. ZP of -36.5 ± 0.20 m
... Show MoreThis study was design to characterize the immune response in experimentally Pseudomonas aeruginosa mastitis mice treated probiotic bifidocin and cazacin of Bifidobacterium spp. and Lactobacillus casei. We quantified the level of the IFN-γ and TNF-α cytokines in blood by ELISA technique. IFN-γ level was significantly higher in infected group compared to control (340.21 ± 41.61, 8.45 ± 0.83 pg/ml, respectively). While the level of IFN-γ was significantly higher in mastitis mice than bifidocin and cazacin treated mice. Also, TNF-α level showed a significant increase in mastitis mice compared to controls (320.11±40.33, 8.45±0.83pg/ml, respectively). Among mastitis and bifidocin (9 and 18 mg/ml), cazacin (11 and 22 mg/ml) treate
... Show MoreThe current study aims to investigate the relationship between lipid peroxidation, represented by seminal malondialdehyde (MDA) level, and integrity of sperm plasma membrane, represented by the hypo-osmotic swelling (HOS) test score, in infertile men. One hundred and twenty Iraqi men (20 fertile and 100 infertile) shared in this study during their attendance to the High Institute for Infertility Diagnosis and Assisted Reproductive Technologies/Al- Nahrain University. The mean age of the fertile men was (30.46±0.78) years while the mean age of infertile men was (32.58±0.64) years with the duration of infertility (5.36±0.33) years. Semen samples were collected and the parameters of seminal fluid analysis were assessed; also, the HOS
... Show MoreBackground: Polycystic ovary syndrome is a heterogeneous disorder and its etiology appears to be complex and multifactorial; characterized by hyperandrogenism, chronic anovulation and infertility. It’s associated with evidence of low-grade chronic inflammation, as indicated by the presence of elevated levels of high sensitive C- reactive protein levels, interleukin-6 and tumor necrosis factor-α. The source of excess circulating tumor necrosis factor-α in obese Polycystic ovary syndrome patient is likely to be the adipose tissues while in lean women increased visceral adiposity has been proposed as a source of excess tumor necrosis factor-α.Objectives: to evaluate the levels of high sensitive C- reactive protein, tumor necrosis facto
... Show MoreBackground : Double diabetes (DD) is the term used to describe situations in which a patient exhibits characteristics that are a combination of type 1 diabetes mellitus(T1DM) and type 2 Diabetes Mellitus (T2DM) a large epidemiological study found that 25.5% of people with T1D also had the metabolic syndrome. A new protein hormone called asprosin is predominantly released by white adipose tissue. It was initially discovered in 2016 . Asprosin is important diagnoses marker for insulin resistant in diabetes patients ,additionally is very important denotation about early diagnoses of type 2 diabetes. Objectives: The current study aims to find predictive significance of diagnosis a double diabetes by evaluating the asprosin in the blood serum of
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