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FKBP51 IMMUNOCYTOCHEMICAL EVALUATION IN INDUCED SPUTUM CELLS OF IRAQI ASTHMATIC PATIENTS
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Asthma is chronic inflammatory disease affecting 5% of world population. Characterized by eosinophilic type2 inflammation. FKBP51 immunophilin, important modular protein of glucocorticoid receptor (GR). We aimed to evaluate immunocytochemical localization of GR and FKBP51 in induced sputum cells by using immunocytochemical method and immunofluorescent ant-FKBP51 and anti –GR antibody and estimation of IgE and Type 2 inflammatory cytokine IL-5,IL-13 by ELISA technique.GR in the sputum show non-significant decrease of cytoplasmic distribution of the patient groups and highly significant increase in steroid treated patients and non-significant increase in nuclear distribution in non-steroid, FKBP51 nuclear localization show non-significant increase in steroid treated and more than control and non-steroid treated patient and non-significant decrease in cytoplasmic localization in asthmatic than control. IgE serum level was highly significant elevated in both asthmatic groups when compared to control (P<0.001), it was in ICS treated asthmatics 297.59± 33.89 IU/ml, in nonsteroid treated 278.23±84.9IU/ml and in control 36.25±7.45 IU/ml, IL-5 show highly significant increase (P<0.001) in both steroid treated and non-steroid asthmatics, but not in control subjects it was 21.82±7.4Pg/ml, 17.97±4.02Pg/ml and 11.08±0.55Pg/ ml, respectively, IL-13 show non-significant increase in asthmatic groups when compared to control, it was 32.58±1.8Pg/ml, 29.14±2.76Pg/ml and 15.8±1.15Pg/ml, respectively. It can be concluded that elevated FKBP51 localization in nucleus in steroid treated patients associated with asthma type 2 inflammation cytokine increase.

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Publication Date
Fri Aug 01 2014
Journal Name
2014 36th Annual International Conference Of The Ieee Engineering In Medicine And Biology Society
Spectral analysis of resting state magnetoencephalogram activity in patients with bipolar disorder
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Publication Date
Thu Nov 08 2018
Journal Name
Iraqi National Journal Of Nursing Specialties
Nutritional status of adult hemodialysis patients in Al-Najaf Al-Ashraf Governorate
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Objective: To assess the nutritional status of hemodialysis patients.
Methodology: A descriptive quantitative cross sectional study was effectuated in hemodialysis centers from
February 2011 to September 2011. A purposive "non-probability" sample of (70) male and female hemodialysis
patients in al-Najaf al-Ashraf Governorate from those who have spent more than six months on maintenance
hemodialysis schedule. Data collected through using of a well-designed questionnaire consist of five parts, part
one consists of sociodemographic contain (9) items, and part two consists of medical data contain (8) items, and
part three consists of health and nutrition behavior contain (12) items plus (8) items of anthropometric
measur

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Publication Date
Fri Mar 15 2019
Journal Name
Journal Of Baghdad College Of Dentistry
Assessment of Dental Calculus, Plaque and GingivalInflammation in Patients with Urinary Stone
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Background: Dental calculus is mineralized dental plaque formed on teeth and dental prosthesis surfaces in the oral cavity. Urinary stone is a crystal aggregation formed in urinary system due to minerals saturation present in urine. The structure of dental calculus is similar to that of urinary stone. Objective: To assess oral hygiene and gingival status in patients with urinary stone. And compared with healthy subjects. Patients and Methods: Sixty participants, 25-40 years, were involved in this study who were divided into study and control group. The study group involved patients with urinary stone while the control group involved healthy subjects. Clinical parameters including plaque, calculus and gingival indices were recorded for al

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Publication Date
Sat Jan 01 2022
Journal Name
Tropical Journal Of Natural Product Research
Detection of Herpes Simplex Virus Type 1 in Patients Affected by Conjunctivitis
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Herpes simplex virus (HSV) is a common human pathogen that causes severe infections in newborns and immunocompromised patients. Conjunctivitis or corneal epithelial keratitis is caused by HSV type 1 all over the world and at all times of the year. The present study was aimed at detecting HSV in patients suffering from conjunctivitis. One hundred and ten (110) clinical samples (90 patients and 20 controls, both males and females) of eye conjunctiva swabs were collected from patients of different ages. The samples were analyzed using qPCR and ELISA techniques. The qPCR results revealed that HSV was present in 47 (52.2%) of the 90 patients who were infected. Of these patients, 25 (48.0%) were males and 22 (57.8%) were females, indicati

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Publication Date
Wed Nov 07 2018
Journal Name
Iraqi National Journal Of Nursing Specialties
Assessment of Nurses’ Practices for Neurological Unconscious Patients in Intensive Care Units
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Objective(s): To assess nurses' practices for neurological unconscious patients in intensive care units.
Methodology: A descriptive study was conducted that included (50) nurse who are working in intensive care
units in hospitals and departments of the nervous system in (4) hospitals (neuroscience hospital, teaching
neurosurgical hospital, surgical specialist hospital, and sheck zaied hospital) in Baghdad city from March, 30th
,
2009 to July, 30th 2009 for the purpose of assessing their skills towards unconscious patients. A purposive "nonprobability
sample" was selected that consisted of (50) nurse who are working in intensive care units. A
questionnaire format and observational checklist were used which consist of

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Publication Date
Sun Jun 30 2013
Journal Name
Al-kindy College Medical Journal
Cognitive Effects of Tumor and Surgical Treatment in Patients with Cerebral Gliomas
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Background: Quality of life in brain tumor patients is an emerging issue and has prompted neurosurgeons to recon¬sider the need for cognitive assessment in the course of treatment. To date there has been a lack of comprehensive neuropsychological assessment performed preoperatively and in the acute postoperative period in our hospitals.Objectives: to establish the effects of tumors and their surgical treatment, from a neuropsychological perspective, on cognitive functioning in patients with cerebral Gliomas. Methods: This is a prospective study conducted in the Neurosurgical Hospital in Baghdad, Iraq, during the period from January 1999 to January 2001. Any patient admitted during the period of the study with clinical history, signs, sy

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Publication Date
Thu Jan 07 2021
Journal Name
Journal Of Craniofacial Surgery
Management of Maxillofacial Trauma in Attempt Suicide Patients During COVID-19 Pandemic
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Publication Date
Tue Mar 28 2017
Journal Name
Iraqi Journal Of Pharmaceutical Sciences ( P-issn 1683 - 3597 E-issn 2521 - 3512)
Therapeutic Response of Serum Lipids to Atorvastatin in Type II Diabetic Patients
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Lipid disorders and cardiovascular disease (CVD) risk are known to be increased in patients with diabetes mellitus. The effects of statins on serum lipid levels are well known; however, previous studies did not compare the effects of statins on serum lipid levels in diabetic patients with non-diabetic patients. To investigate the effects of Atorvastatin on serum lipid profiles in hyperlipidemic patients with type 2 diabetes mellitus in comparison with hyperlipidemic patients without diabetes.This study was conducted on 33 type 2 diabetic patients & 34 non-diabetic patients; their age range was 40-80 years, all of them were hyperlipidemic, who had been administered 10, 20, & 40 mg daily of Atorvastatin and completed a 6-month foll

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Publication Date
Tue Jan 12 2016
Journal Name
Al-mustansiriyah Journal Of Science
Studying of Kidney , Liver Functions and Some Blood Ions In Toxoplasmosis Patients
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The present study was conducted to investigate the effects of toxoplasmosis on liver, kidney and some blood ions such as calcium, potassium & sodium. A total of 100 blood samples were obtained from pregnant women in several health centers in Baghdad city. which consist of 70 seropositive & 30 seronegative/control group, aged between 20 & 47 years old from September 2013 till September 2014. All of these cases were tested to specific antibody to Toxoplasma gondii by using a latex agglutination test and IgM & IgG antibodies using the ELISA technique. The serum samples were examined for liver function (serum aspartate aminotransferase [AST/GOT], serum alanine aminotransferase [ALT/GPT] and serum alkaline phosphatase [ALP]; kidney function (ser

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Publication Date
Thu Apr 18 2019
Journal Name
Al-kindy College Medical Journal
Correlating CT findings of stroke with hyperglycemia in acute ischemic stroke patients
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Background: Studies show that diabetic patients have a higher incidence of ischemic stroke than non-diabetic patients. In the Framingham study the incidence of thrombotic stroke was 25 times higher in diabetic men and 36 times higher in diabetic women than in those without diabetes

Objectives: aim of this study to analyze topography in diabetic patients.

Type of study:  Cross sectional study.

Methods: 48 patients with acute stroke were classified into 4 groups: euglycemic, stress hyperglycemia, newly diagnosed diabetics, and known diabetics.

Results:no significant differences were found in the type, site or size of st

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