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Personalised Warfarin Dosing in Children Post-cardiac Surgery
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Abstract<p>Warfarin dosing is challenging due to a multitude of factors affecting its pharmacokinetics (PK) and pharmacodynamics (PD). A novel personalised dosing algorithm predicated on a warfarin PK/PD model and incorporating CYP2C9 and VKORC1 genotype information has been developed for children. The present prospective, observational study aimed to compare the model with conventional weight-based dosing. The study involved two groups of children post-cardiac surgery: Group 1 were warfarin naïve, in whom loading and maintenance doses were estimated using the model over a 6-month duration and compared to historical case-matched controls. Group 2 were already established on maintenance therapy and randomised into a crossover study comparing the model with conventional maintenance dosing, over a 12-month period. Five patients enrolled in Group 1. Compared to the control group, the median time to achieve the first therapeutic INR was longer (5 vs. 2 days), to stable anticoagulation was shorter (29.0 vs. 96.5 days), to over-anticoagulation was longer (15.0 vs. 4.0 days). In addition, median percentage of INRs within the target range (%ITR) and percentage of time in therapeutic range (%TTR) was higher; 70% versus 47.4% and 83.4% versus 62.3%, respectively. Group 2 included 26 patients. No significant differences in INR control were found between model and conventional dosing phases; mean %ITR was 68.82% versus 67.9% (<italic>p</italic> = 0.84) and mean %TTR was 85.47% versus 80.2% (<italic>p</italic> = 0.09), respectively. The results suggest model-based dosing can improve anticoagulation control, particularly when initiating and stabilising warfarin dosing. Larger studies are needed to confirm these findings.</p>
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Publication Date
Wed Dec 30 2015
Journal Name
College Of Islamic Sciences
Altruism in Islamic thought
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Praise be to Allah, Lord of the Worlds, and peace and blessings be upon our Lord and Beloved Muhammad and his family and companions.
The altruistic submission of the other human himself in matters of the world satisfactory to God Almighty with his need and does not come out limit want and destruction. The approach of the Koran in the income creation altruism education for the individual curriculum that includes types of altruism, including Mahmoud and vilified. Ether world life on the hereafter is a vilified type and its consequences are sterile on the existing in the world and in the hereafter a serious consequence, which is special Madiat. On the principle and preference of the doctrine over the doctrine, the Koran has been interest

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Publication Date
Wed Jun 14 2023
Journal Name
Al-academy
Luxury in jewelry design
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The current research dealt with the presence of ornaments and jewelry since ancient times، which express the social، religious or emotional status of the person who adorns them، in addition to being distinguished by a distinct aesthetic and luxury، that is، in a sense closely related to the social and economic status of people، and we note that jewelry is considered a symbol of luxury and luxury، and hence The need to study luxury appeared in the design of ornaments and jewelry because it refers to the adornment elements that are made of metals and precious stones، which actually indicate signs of status or position that distinguish social classes from each other. The problem was identified by the following question: Determine th

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Publication Date
Tue Aug 15 2023
Journal Name
Al-academy
Communication in art Education
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The aim of this research is to find approaches between the communicative process and the teaching of art education. Postgraduate/Masters studies for the academic year 2022-2023.
In the light of this tool, the researcher reached a number of results, most notably: The art education teacher performs his communicative role correctly, as well as his ability to use verbal and non-verbal expressions and positive reinforcement clearly for the benefit of his students, and stimulates the largest number of their senses

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Publication Date
Sat Oct 04 2025
Journal Name
Nasaq
Religiosity in Iraqi society
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Publication Date
Sun Sep 01 2013
Journal Name
Iosr Journal Of Applied Chemistry (iosr-jac)
Neonatal Omphalitis in Iraq
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Publication Date
Thu Oct 01 2009
Journal Name
Journal Of The College Of Languages (jcl)
Schematic Coherence in Poetry
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Schemata are the underlying connections that allow new experience and information to be aligned with previous knowledge. When one reads a text he usually uses all his levels of schemata. Schemata enable us to make sense of what is perceived and experienced in the world.

In poetry, readers usually examine carefully and deeply what they are reading in comparison with other sorts of discourse. Coherence is achieved when a reader perceives connections among schemata. It is a connection between linguistic and textual features of the text, and reader's mental expectations as well as stored knowledge of the world. This paper discusses the role of schematic correlation in poetry, and the effect of different schematic background and diffe

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Publication Date
Wed Dec 30 2020
Journal Name
Al-kindy College Medical Journal
Furosemide in Hypovolemic shock
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Background: Shock is a common clinical state, we face chocked patients in causality, surgical and gynecological  specialties like stab wounds, road traffic accidents, placenta preavia, placenta accrete, placenta pericreta, ectopic pregnancy, perforated viscus  etc. All such patients undergo surgical exploration and majority of them are shifted to ICU to complete monitoring and support. High percent of them they develop acute kidney injury intra and postoperatively and carry high mortality rate because of not so good nursing care in ICU in Iraq.

Objective: to clarify that Furosemide can protect kidney function during shock and reduce ICU admission and mortality rate.

Method: 100 shocked patient were enrolled in t

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Crossref
Publication Date
Wed Oct 30 2019
Journal Name
Cambridge Scholars Publishing.
Intelligent systems in building;
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Publication Date
Sat Feb 09 2019
Journal Name
Journal Of The College Of Education For Women
Excellence in Language Education
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The primary goal of the study is to practise some systematic strategies for foreign language instruction despite the fact that no single approach to language classroom instruction is inherently superior to others; instead the choice of an approach should be determined by the teacher, students, the subject matter, and the situation. The paper adopts certain strategies which may assist EFL teachers to excel in their work and continue their professional development. Hence, it is intended for language teachers who understand the value of good teaching and like to produce academically successful students. The study could also help college student teachers to acquire new strategies in order not only to succeed but also to excel in their learni

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Publication Date
Sun Nov 02 2014
Journal Name
International Journal Of Engineering Research And General Science
Security in Cloud Computing
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Becloud stupefy computing is solid buzzword in the trade. It is timeless in which the advantage seat be leveraged on sound out miserable take into consideration reducing the indict and complication of grant providers. Cloud computing promises to curtail truly and opinionated retrench and approximately specifically concede IT departments focusing on moral projects as contrasted with of misery datacenters contention, It is unconditionally with than on the up internet. Give are sundry consequences of this put together. For the actuality remodeling in turn flock cause get revenge buyer be attractive to. This implies ramble they chaperone custody of servers, they carry out software updates and assistant on the condense user pay

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