Spectrophotometric Estimation of Methyldopa Drug in pure and pharmaceutical formulations

Saba Salman

doi:10.21608/EJCHEM.2024.248561.8873

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Publication Date

Wed Feb 07 2024

Journal Name

Egyptian Journal Of Chemistry

Issue Number

8

DOI

10.21608/EJCHEM.2024.248561.8873

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Spectrophotometric Estimation of Methyldopa Drug in pure and pharmaceutical formulations

Methyldopa

Spectrophotometry

Sodium nitrite

Metoclopramide

Sulfamic acid.

Saba Salman

Husam Saleem Khalaf

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Publication Date

Sun Sep 01 2013

Journal Name

Baghdad Science Journal

In Vitro Study of MefenamateStarch as Drug Delivery System

Mefenamic acid

Starch

natural polymers

esterfication

Firyal M.

Firas A.

Aseel Q.

Huda M.

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Mefenamic acid was esterified with starchwith[1:1] Molar ratio, as drug substituted with natural polymer, to prolongthe period of hydrolysis of drug polymer with other advantages. The new prodrug starch was characterized by FT-IR and UV-Visible and 1H-NMR spectroscopies. The physical properties were studied and controlled drug release was studied in different pH values at 37oC. The stability of drug was carried out by measuring the absorbance of mefenamic starch which hydrolyzed in HCl solution of pH 1.1 (artificial gastric fluid) and phosphate buffer of pH 7.4 (simulating intestinal fluid SIF) at 37oC for several days. The thermal analysis such as DSC was studied.

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Publication Date

Fri Dec 31 2021

Journal Name

Iraqi Journal Of Market Research And Consumer Protection

DETERMINATION OF CEFALAXIN IN PHARMACEUTICAL PREPARATION BYMOLECULARY IMPRENTED POLYMER IN PVC MATRIX MEMBRANE: DETERMINATION OF CEFALAXIN IN PHARMACEUTICAL PREPARATION BYMOLECULARY IMPRENTED POLYMER IN PVC MATRIX MEMBRANE

Keywords: Molecularly imprinted polymers(MIP)

Cefalexin

vinyl acetate (VA) monomer

1-vinylimidizol (VIZ) monomer.

Huda J.

Yehya K.

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This current study was built on creating four electrodes based on molecularly imprinted polymers (MIPs). As the template using Cefalexin (CFX), 1-vinyl imidazole (VIZ) and vinyl acetate (VA) as monomer, and N, N-methylene bis acrylamide (MBAA) as cross-linkers and benzoyl peroxide as the initiator, two MIPs were prepared. The same composition was used in non-impressed polymers (NIPs) preparation, but without the template (Cefalexin). For the membranes preparation, numerous plasticizers, such as tri-oly phosphate (TOP) and di-octyl phthalate (DOP), were used in the PVC matrix, slop, detection limit, lifetime, and linearity range of CFX-MIPs electrodes are characteristics &nb

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Publication Date

Fri Jul 11 2025

Journal Name

Scientific Reports

Molecular docking study and pharmacokinetic insights of rifampicin in pure and capsule dosage forms

Nahla A.

Azhar S.

Majid S.

Suresh

Ayman A.

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To detect the amount of rifampicin in bulk and medicinal dosage formulations, an accurate and costeffective UV spectrophotometric technique has been developed using the area under the peak to estimate the presence of rifampicin. This range of wavelengths (300–356 nm) was chosen. The method showed linearity in the 2–22 μg/mL range, with R2 being2 0.9996. The developed method’s linearity, detection limit, quantification limit, precision, repeatability, and accuracy were all statistically and experimentally validated. The suggested methodology can be used for routine quality control analysis of rifampicin in pure form and in capsule dosage form, as demonstrated by the satisfactory recovery percentage results. This study explores the str

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Publication Date

Fri Dec 31 2021

Journal Name

Iraqi Journal Of Market Research And Consumer Protection

ULATRAVIOLET ABSORBANCE SEPECTRA FOR ANTIBIOTIC DERIVATIVES (AMINO GLYCOSIDES) USED IN MEDICAL AND PHARMACEUTICAL INDUSTRY: ULATRAVIOLET ABSORBANCE SEPECTRA FOR ANTIBIOTIC DERIVATIVES (AMINO GLYCOSIDES) USED IN MEDICAL AND PHARMACEUTICAL INDUSTRY

Key words: Amino glycosides

organic reagents

ultraviolet-visible spectrometer

melting point apparatus.

Anud M. A.

Ziadan J.

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Ultraviolet spectrophotometric studies for antibiotic (amino glycoside) derivatives including, Neomycin, Streptomycin, Gentamycin and Kanamycin with special reagents, which are benzoyl chloride; benzene sulfonyl chloride, toluenesulfonyl chloride and phthalic anhydride were made. Amino glycosides derivatives were followed through measurements of the ultraviolet absorbance (A) from which the absorptivity (ε) of the complexes was deduced and molar absorbances using Ultraviolet for products and calculate the number of reagents molecule that combine to amino glycosides.

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Publication Date

Sun Dec 01 2013

Journal Name

Baghdad Science Journal

Construction of New Ion Selective Electrodes for Determination Fe(III) and Their Application in Pharmaceutical samples

Iron(III) selective electrodes

Chloramphenicol sodium succinate

Khaleda H.

Weaam R.

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Liquid membrane electrodes for the determination iron(III) were constructed based on chloramphenicol sodium succinate and iron(III) CPSS-Fe(III) as ion pair complex, with four plasticizers Di-butyl phosphate (DBP); Di-butyl phthalate (DBPH); Di-octyl phthalate (DOP); Tri-butyl phosphate (TBP); in PVC matrix . These electrodes give Nernstian and sub-Nernstian slopes (19.79, 24.60, 16.01 and 13.82mV/decade) and linear ranges from (1x10-5-1x10-2 M, 1x10-5-1x10-2 M, 1x10-6-1x10-2 M and 1x10-5-1x10-2 M) respectively. The best electrode was based on DBP plasticizer which gave a slope 19.79 mV/decade, correlation coefficient 0.9999, detection limit of 9×10-6 M, lifetime 37 day displayed good stability and reproducibility and used to determine

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Publication Date

Wed Aug 02 2023

Journal Name

African Journal Of Advanced Pure And Applied Sciences (ajapas)

African Journal of Advanced Pure and Applied Sciences (AJAPAS)

Hiba

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African Journal of Advanced Pure and Applied Sciences (AJAPAS)

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Publication Date

Mon Dec 30 2002

Journal Name

Iraqi Journal Of Chemical And Petroleum Engineering

Aerobic Filter Treatment of Pharmaceutical Waste

Nahidh W

Hammodi A

Kassim H

Abbas H

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Publication Date

Mon Feb 14 2022

Journal Name

Proceedings Of The National Academy Of Sciences

Pharmaceutical pollution of the world’s rivers

John L.

Alistair B.A.

Dana W.

Kenneth M. Y.

Racliffe W. S.

Cristóbal

Aiko D.

Julie

Marc

Robert A.

Alejandra

Aida

Anja

Pedro

Macarena

Chris

Magdalena

Monique

Thais

Vahagn

Yekaterina

Clare S.

Christopher J.

Thilo

Tapos

Volga

Jessica

Jean L.

Francisco

Maria T. P.

Victorien

Gildas

Oumar

Jules M.

Linda E.

Michelle

Donald

Romaric

Jaime

Guang-Guo

Chang-Er

Martha

Jina

Jean-Paul

John

Suspense A.

Penelope

Silvia

Nikolina

Milena

Despo

Lida

Vladimíra

Jan

María

Bayable A.

Jeanne

Arnaud

Peter

Ilia

Sven

Gerasimos

Halldór P.

Molly

Thatikonda

Manisha

Anindrya

Adee

Nima

Ali

Omar

Salem S.

Francesco

Benny

Tom

Koffi Marcellin

Bakhyt

Raikhan

Lydia

Jemimah K.

Peter

Victor

Nathaniel T.

Sheck

Ahmad Zaharin

Ley Juen

Mahamoudane

Seydou T.

Rik

Olatayo

Muhammad

Ziad

Aaron

Jorge Manuel

María

Heidi

Ian

Fabio

Alhaji Brima

Bashiru M.

Vesna

Mitja

Melusi

Kyungho

Habyeong

John L. Celestino

Andreu

Priyanie

Anna

Gisela

Armin K.

Alex C.

Jheng-Jie

Rebecca

Madaka

Ulas

Turgut T.

Julius B.

Yuliya

Yuriy

Horacio

Andrés

Douglas B.

Maritza

David

Charles

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Environmental exposure to active pharmaceutical ingredients (APIs) can have negative effects on the health of ecosystems and humans. While numerous studies have monitored APIs in rivers, these employ different analytical methods, measure different APIs, and have ignored many of the countries of the world. This makes it difficult to quantify the scale of the problem from a global perspective. Furthermore, comparison of the existing data, generated for different studies/regions/continents, is challenging due to the vast differences between the analytical methodologies employed. Here, we present a global-scale study of API pollution in 258 of the world’s rivers, representing the environmental influence of 471.4 million people across

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Publication Date

Sun Mar 26 2017

Journal Name

Iraqi Journal Of Pharmaceutical Sciences ( P-issn 1683 - 3597 E-issn 2521 - 3512)

Bioequivalence and Pharmacokinetics Comparison of Two Formulations of Extended-Release Pentoxifylline Tablets in Healthy Subjects after Fasting and Fed Conditions

Jaafar

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The pharmacokinetics and bioequivalence of a newly developed extended-released (ER) tablet containing 400 mg pentoxifylline as a test product was compared with the reference brand product Trental^Â® 400 mg ER tablet produced by Sanofi-Aventis. Two separate studies were conducted simultaneously. The first study was conducted under fasting condition, whereas, the second study was conducted under fed condition; using the same batches of the test and reference products in both studies. In each study, both products were administered to 32 healthy male adult volunteers applying a single-dose, two-treatment, two-period, two-sequence, randomized crossover design with one-week washout period between dosing. Twenty two blood samples we

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Publication Date

Fri Mar 31 2017

Journal Name

Al-khwarizmi Engineering Journal

Design and Implementation of a Pharmaceutical Inventory Database Management System

Inventory Database Management System

Invoicemedicine

Pharmaceutical

Sama Salam

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The main aim of this paper are the design and implementation of a pharmaceutical inventory database management system. The system was implemented by creating a database containing information about the stored medicines in the inventory, customers making transactions with the pharmaceutical trading company (which owns the inventory), medical suppliers, employees, payments, etc. The database was connected to the main application using C sharp. The proposed system should help in manag inginventory operations which include adding/updating employees’ information, preparing sale and purchase invoices, generating reports, adding/updating customers and suppliers, tracking customer payments and checking expired medicines in order to be disposed

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