New derivatives of the anti-inflammatory, leprostatic drug dapsone 4 are synthesized, characterized and biologically screened by the treating the drug dapsone with chloroacetyl chloride in the presence of base. Both amino groups are acylated to give compound 6. The symmetrical acylated product then treated with Phenol, N-Acetyl-p-aminophenol, p-Chlorophenol, m-Chlorophenol, o-Hydroxybezoic acid and m-Hydroxybezoic acid to give compounds 8(a-f). The antimicrobial activity was tested for the synthesized compounds; activates were good compared to the parent drug. All the new compounds have scanned for their biological activities toward gram ‒ve and gram +ve (M. tuberculosis, S. pneumoniae, E. coli and P. mirabilis) bacteria, the synthesized derivatives gave moderate to good activity toward both mentioned types of bacteria.
Synthesis, Characterization and Biological Activity of
New Compounds Derived from Dapsone
dapsone
sulfones family
Antibacterial activity
Publication Date
Mon Jan 01 2024
Journal Name
Anais Da Academia Brasileira De Ciências
Morphological study for Accipitrid birds (Accipitridforms, Accipitridae) in Iraq; part two
A part two of Accipitridae Family members that belong to three genera:
Circus
Gyps
and Neophron were documented as morphometrics
distribution ranges
and conservation status were reviewed and comprehensively discussed. A total of
29 voucher specimens belong to six species which are conserved in the “Iraq Natural
History Research Center and Museum INHM” as follow: Marsh Harrier Circus aeruginosus
(Linnaeus
1758)
Hen Harrier Circus cyaneus (Linnaeus
1766)
Montagus Harrier Circus
pygargus (Linnaeus
1758)
Pallid Harrier Circus macrourus (Gmelin
1770)
Egyptian
vulture Neophron percnopterus (Linnaeus
1758)
and Griffon vulture Gyps fulfus (Hablitz
1783). The results revealed significant criteria about near threatened NT species IUCN
and Birdlife International listed as Pallid Harrier Circus macrourus
and Endangered
(EN) species as Egyptian vulture Neophron percnopterus globally decreasing population
trend.
