Protein arginine methyltransferases (PRMTs) play important roles in transcription, splicing, DNA damage repair, RNA biology, and cellular metabolism. Thus, PRMTs have been attractive targets for various diseases. In this study, we reported the design and synthesis of a potent pan-inhibitor for PRMTs that tethers a thioadenosine and various substituted guanidino groups through a propyl linker. Compound II757 exhibits a half-maximal inhibition concentration (IC50) value of 5 to 555 nM for eight tested PRMTs, with the highest inhibition for PRMT4 (IC50 = 5 nM). The kinetic study demonstrated that II757 competitively binds at the SAM binding site of PRMT1. Notably, II757 is selective for PRMTs over a panel of other methyltransferases, w

استهدف البحث الحالي تعرف أنماط الشخصية الإنيكرام السائدة ضمن مركز الغريزة لدى طلبة قسم التربية الخاصة، وكذلك تعرف أنماط الشخصية الإنيكرام السائدة ضمن مركز الغريزة لدى طلبة قسم التربية الخاصة وفقاً لمتغير النوع (ذكور، إناث)، ولتحقيق هذه الأهداف تم اعتماد الصورة المختصرة لمقياس أنماط الشخصية الإنيكرام المُعد من قبل (ريسو-هيودسن، 1995)، ترجمة (الياسري، 2004)، (تقنين: السلطاني، 2007)، وقد تم التحقق من الخصائص السيكومت

اصبح مصطلح الصورة الذهنية من المصطلحات الشائعة التي يتزايد استخدامها في المجالات السياسية والإعلامية والعلاقات الدولية اذ اصبح يشكل اهمية كبرى لدى دراسي السلوك الانساني، فقد احتلت دراسة المصادر المتعددة التي يستقي منها الافراد انطباعاتهم عن الاخرين، وتعاظم الدور الذي تلعبه وسائل الاتصال في تدفق الصور عن الشعوب في ظل التطور التكنولوجي الهائل الذي يشهده عالم الاتصال حاليا، والذي يسمى بعصر السموات المفتوحة

Given the growing interest in digital marketing operations and the technology imposed by the reality in which both companies and their customers are affected, the researchers attempted to shed light on the reality and challenges of digital marketing from the faculty members viewpoint at Jouf university, the problem is that technology has imposed a new reality that has resulted in a major change in behavioral patterns of customers with a number of obstacles and challenges confronted customers in digital marketing, it is expected that the outcomes of this study help companies in overcoming the obstacles that prevent the desire and ability of the customer to change his behavioral style to deal with electronic shopping operations and

The research studies the synthetic sculpture techniques in the outputs of the students of the department of art education in terms of the shape, texture, content and technique, and employing this style by the students of the department of art education on the college of fine arts, university of Diyala. The research consists of four chapters: the first chapter: the research problem summarized by looking for the synthetic sculpture and its importance in the treatment the industrial wastes in our social life, according to modern synthetic techniques, in the American and European sculpture. This technique has been employed in more than one contemporary artistic direction and style.
This study is considered important for the students of t

Abstract:

Viral marketing has become one of the modern strategies adopted by organizations in the marketing of products and services. The idea of viral marketing focuses on the social relations between individuals and groups. As a result of the technological development, most organizations have resorted to using the Internet and its applications and social media to market and promote their products. To reach the largest number of consumers to display their products and services in many ways, including text, audio, visual or video and thus affect the behavior of the consumer.

The problem of the study was the following question (do viral marketing technologies have an impact on consumer behavior?)

<span lang="EN-US">Increase the in population and kindergarten number, especially in urban areas made it difficult to properly manage waste. Thus, this paper proposed a system dedicated to kindergartens to manage to dispose of waste, the system can be called smart garbage based on internet of things (SGI). To ensure a healthy environment and an intelligent waste in the kindergarten management system in an integrated manner and supported by the internet of things (IoT), we presented it in detail identification, the SGI system includes details like a display system, an automatic lid system, and a communication system. This system supplied capabilities to monitor the status of waste continuously and on IoT website can show the pe

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