An experimental investigation of natural convection heat transfer from an isothermal horizontal,vertical and inclined heated square flat plates with and without circular hole, were carried out in two cases, perforated plates without an impermeable adiabatic hole "open core" and perforated plates with an impermeable adiabatic hole "closed core" by adiabatic plug. The experiments covered the laminar region with a range of Rayleih number of (1.11x106 ≤RaLo≤4.39x106 ), at Prandtle number (Pr=0.7). Practical experiments have been done with variable inclination angles from horizon (Ф=0o ,45o,90o,135oand 180o),facing upward (0o≤Ф<90o), and downward (90o
≤Ф<180o). The results showed that the temperature gradient increases while the thermal boundary layer thickness decreases when Grashof number and perforation ratio (m) increase . The temperature gradient for inclined position facing upward is less than facing downward,while the thermal boundary layer thickness is greater. The temperature gradient decreases while the thermal boundary layer thickness increases for perforated plates with an adiabatic core as compared with perforated plates without an adiabatic core. The value of average Nusselt number increases with increasing perforation ratio, and Grashof number for all specimens with and without an adiabatic core, also increases by increase in inclination of plates approaching the higher value at vertical position (Ф=90o
), then decreases with increasing inclination of plates till horizontal position (Ф=180o). The average Nusselt number values for perforated plates with an adiabatic core are lower than for perforated plates without an adiabatic core for all perforation ratios. Maximum heat transfer rate occurs at perforated plate with perforation ratio of (m=0.1) without adiabatic core for vertical position (Ф=90o), at a range of Grashof number (1.576x106≤GrLo≤6.292x106 ), while the rate of heat transfer decreases with increasing perforation ratio for plates with and without adiabatic core for decrease in heat transfer rate area. The rate of heat transfer for
perforated plates with circular hole is more than for perforated plates with square hole at the same perforation ratios (m=0.1,0.16,0.24 and 0.36). It found that the lack of core flow decreases the overall heat transfer rate by (6.477%) . There was a good agreement for the experimental present work results compared with other pervious results .