The objective of this work was to determine and compare the physiological changes in some: blood components (packed cell volume and hemoglobin) and plasma biochemical parameters (glucose, total protein, albumin, cholesterol and triglycerides) under 3 day of different types of stress: water deprivation, starvation, overcrowding and handling stress. Twenty five male Wister rats weighted 100-120 gm, were divided randomly into five groups: control, water deprivation, starvation, overcrowding and handling stress. On the third day of stress the animals anesthetized for blood collection; the results of blood component revealed a significant increase in PCV and a significant decrease in Hb of water deprivation group and starvation group respectively. The biochemical changes showed a significant elevation in glucose concentration of starved rats; also there was a significant increase in total proteins of starved rats and overcrowding group, beside there was a significant increase in albumin concentration of water deprivation group, finally the cholesterol and triglycerides showed a significant increase in starved rats. In conclusion the starved rats showed more changes in blood and biochemical parameters followed by water deprivation group, overcrowded and handling stress respectively.