CFIA
Turbidity
sodium
nitroprusside
chlorpheniramine
maleate
NAG-SSP-5S-1D Analyzer
Spectrophotometric method
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This study presents a rapid, sensitive, and straightforward approach to measure
chlorpheniramine maleate (CPM) by using turbidity CFIA. The method involves CPM reacting
with sodium nitroprusside (Nitropress) to produce a pale white precipitate. The NAG-SSP-5S1D analyzer was used to measure turbidity at 0°–180° angle to detect the attenuation of
incident light as a result of collision on the surfaces of the precipitate particles.
The linear range of CPM measurements was between 0.008 and 11 m.mol/L, with
correlation coefficient of 0.9983 and R2% = 99.65. The limit of detection was determined to
be 0.0328 µg/sample from the lowest concentration in the calibration curve, and the
repeatability of the method (RSD%) was less than 0.4% (n = 6
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