Background: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy affecting women, at reproductive age. PCOS is a chronic hyperandrogenic state that has many significant short-term and long-term implications for patients such as oligomenorrhea, amenorrhea, infertility, diabetes mellitus, cardiovascular disease, increased risk of endometrial cancer, and hirsutism. Objectives: To evaluate the obesity and glycemic criteria among women with polycystic ovary syndrome. Method: A case control designed study was carried out at the National Diabetes Center (NDC) / Al-Mustansiryia University; on 50 participants formed the PCOS group and 50 healthy control participants. Data collected about age, age at menarche and BMI. Also, blood samples examined for FPG and 2-h OGTT test carried out for all the participants. Moreover hormonal assessment for the LH, FSH and total testosterone were done for all participants. Results : PCOS group women age and age at menarche were 27.62 ± 5.74 and 12.0 ± 1.06 years; vs. the control group were 25.42 ± 4.94 and 11.64 ± 0.69 years respectively. All PCOS group were experienced signs and symptoms of ovarian dysfunction, and infertility while the control group did not experience any of such evidences. BMI showed significant difference between study groups (t-test (P < 0.05)); 98% of the PCOS group was obese vs. 58% of the control group. The waist/hip ratio showed insignificant difference (t-test (P > 0.05). Fasting plasma glucose (FPG) showed insignificant difference between the study groups (t-test (P >0.05); about 18% of the PCOS group was prediabetic (Impaired Fasting Glucose, IFG) (100-125mg/dl) and 6% was diabetic (>126mg/dl) whereas the entire control group was normoglycemic. The OGTT showed significant difference between the study groups (ttest (P < 0.05)); about 22% of the PCOS group was prediabetic (Impaired Glucose Tolerance, IGT) (140- 199mg/dl) and 6% was diabetic (>200mg/dl) whereas the entire control group was normoglycemic. PCOS group showed highly significant elevation in the LH level vs. the control group by about four folds (t-test (P < 0.05)). Also, FSH showed similar elevation by about two folds among the PCOS group vs. the control group (t-test (P < 0.05)). Moreover the LH/FSH ratio was elevated by about two folds among the PCOS group vs. the control group (t-test (P < 0.05)). Total serum testosterone of the PCOS group showed significant raise vs. the control group (t-test (P < 0.05)). Whole the PCOS group had A total testosterone level >60 ng/dL and in contrary the entire control group didn't show any elevation >60ng/dl. Conclusion: obesity of android (central) type was frequent and prevalent among PCOS women. About 20-28% of PCOS women was prediabetic or diabetic due to insulin resistance and decreased insulin sensitivity. Hormonal assay of LH, FSH, LH/FSH ratio and total testosterone were all significantly elevated by two folds or more among the PCOS women. It is not essential that a woman who had polycystic ovaries by ultrasound to have PCOS
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Background: Joint hypermobility was first mentioned by Hippocrates as an isolated feature, when he described the Celts' Incapacity to Pull a Bowstring or Throw a Dart, Due to The Slackness of Their Limbs
Objective: to determine the prevalence of mitral valve prolapse(MVP)in patients with benign hypermobility syndrome (BJHS).
Type of the study: Cross –sectional study.
Methods: Ninety patients with BJHS were included in this study. Full cardiological assessment was done for all of them, which include clinical examination, electrocardiography and echocardiography. Cardiac assessment was done for another sixty age and sex matched (
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Abstract:
Background: Retinol binding protein 4 (RBP4), an adipokine that participate in a lipid metabolism or insulin resistance through a complex regulatory network. Recently, RBP4 was reported to be associated with many cardiovascular diseases (CVDs) risk factors in patients of type 2 diabetes mellitus (T2DM). This study aims to study the correlation of serum RBP4 with some markers of glycemic control, dyslipidemia, hypertension and obesity in T2DM Iraqi patients.
Subjects and Methods: one hundred fifty participants were enrolled in this coss-sectional study, 120 of participants were T2DM patients and 30 were apparently healthy individuals to serve as control gro
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In this paper, some necessary and sufficient conditions are obtained to ensure the oscillatory of all solutions of the first order impulsive neutral differential equations. Also, some results in the references have been improved and generalized. New lemmas are established to demonstrate the oscillation property. Special impulsive conditions associated with neutral differential equation are submitted. Some examples are given to illustrate the obtained results.
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This study aimed to explain the criteria of managers at different levels of nursing in selecting effective nursing diagnosis.
In conventional content analysis, 10 nursing managers at different levels including head nurse, supervisor, and nursing manager were interviewed. Data was collected with semi-structured interviews and a narrative approach. Data analysis was performed using the Zhang–Wildemuth method simultaneously with sampling.
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Background: Metabolic syndrome (Mets) is partially heritable. High mobility group AT-hook1 (HMGA1), an architectural transcription factor, affects the homeostasis of glucose. The marked inter-individual differences between T
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Tirzepatide is a revolutionary and promising medication with a high impact in the treatment of Obesity and T2DM with their complications. Its efficacy was proven through different trials in achieving favorable weight loss and a significant reduction in glycemic index. It also treated a large diversity of related co-morbidities, including fatty liver, cardiovascular disease, dyslipidemia, and more. Tirzepatide is well tolerated, has a good safety profile, and is highly reliable and suitable for use in a population.
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ABSTRACT : Diabetes mellitus stands for a set of metabolic diseases that if they are not managed, they can initiate threatening life problems. This study hypothesizes that insulin-like growth factor-1 level can be used as a biomarker for early diagnosing renal problems in patients with type 2 diabetic disease. This study included 30 recently identified type 2 diabetic patients with acute renal malfunction who had an entrance in National Diabetic Center,AL-Mustansiriyah University.They have beenin the Center from October 2018 up to end of April 2019. Their age range has been (40-62) years. Comprehensive clinical investigationhas beencompleted for each patient to discount other diabetic complications like cardiac, neurologic and eye complicat
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