Background: Indeterminate colitis (IC), a term
originated by pathologists to characterize confounding
histopathlogic appearance of resected mucosa, has
become catch phrase for cases in which diagnostic
criteria at all levels elude classification as Crohn's
disease (CD) or ulcerative colitis (UC).
OBJECTIVES: evaluate the prevalence of pANCA
expression in the sera and its isotypes.
Patients and methods: PATIENTS GROUP
consisted of 60 patients (40 males and 20 females)
with indeterminate colitis and their age range was (19-
84 years). CONTROL GROUP consisted of 30 (15
males and 15 females) healthy volunteers and their
age range was (20- 66 years).
Antineutrophil cytoplasmic ( pANCA and cANCA)
testing was performed by an IIF technique on ethanol
fixed human EOH granulocytes as substrate
(EUROIMMUNE- Germany). Sigmoidoscope and
colonoscope examination were done for the patients
group and biopsies were taken from the patients for
histopathological examination.
Results:
Serological results of ANCA showed a significant
increased frequency of pANCA (63.3%) in
indeterminate colitis patients as compared to controls
(p=0.000). The highest percentage of this pANCA
titer was 1:10 (p=0.000) then 1:100 (p=0.008) and
most of them was IgG (53.3%) (p=0.000). Sensitivity
of pANCA was 60%, specificity of pANCA was 40%,
positive predictive value of pANCA was 61.1% and
negative predictive value of pANCA was 66.6%.
cANCA did not demonstrated in both groups.
Conclusions : pANCA was more prevalent in
indeterminate colitis and could be used as a predictive
serological marker for the outcome of disease.
A total of 41 patients with gastro duodenal symptoms (show signs of inflammation with or without duodenal ulcer) . 21 males (51.2%) and 20 female (48.8%) with an average age 0f (20 – 80) years old under going gastrointestinal endoscopy at Baghdad teaching hospital in internal disease clinical laboratory , between (February – June) 2009 . Biopsies specimen of antrum , gastric fundus ,& duodenal bulb were examined by the following methods (rapid urease test , Giemsa stain section to detect bacteria , & Haematoxilin and Eosin stained section for pathological study which are considered the gold standard methods , sera or plasma from these patients were tested by immunochromotography (ICM),serological m
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(1)
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(5)
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(8)
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