Background: Intramedullary astrocytomas
account for about 1% of all CNS tumors and
6–8% of spinal cord tumors. The vast majority
of intramedullary astrocytomas are slowgrowing
lesions.
Objectives: The goal in this study was to
review a series of patients who underwent
surgical removal of intramedullary high-grade
astrocytomas, focusing on the functional
outcome and the effect of multimodality
treatment on the survival of patients with high
grade intramedullary astrocytoma.
Methods: Between June 1999 and June 2004,
22 patients underwent removal of
intramedullary high-grade astrocytomas in four
neurosurgical hospital in Baghdad/ Iraq
(Neurosurgical hospital, Al Shaheed Adnan
Hospital for Surgical Speeialticsa, Nursing
Home Hospital Lesions were located in the
cervical segment of the spinal cord in 12
patients, and patients.
Results: Histological examinations showed
10 Grade III astrocytomas and 12
glioblastomas. Only 2 of the 22 high-grade
astrocytomas could be completely removed. The
clinical postoperative status worsened in
14 patients (63.6%), was unchanged in seven
patients (31.8%), and there was one case of
intraoperative death (4.5%). None of the 22
patients showed improvement in their
neurological status postoperatively. In this series,
excluding the one intra-operative death, all
patients died of the progression of the
malignancy.
Conclusions: Surgical treatment did not
ameliorate the postoperative neurological status;
instead, in the majority of cases, it prompted a
worsening of the deficit. Radiotherapy and
chemotherapy have a little influence on the
length of survival. In this series, multimodality
treatment of intramedullary high-grade
astrocytomas has been shown to increase length
of survival without improving the neurological
status.
The ligand 2-[1-(1H-indol-3-yl)ethylimino) methyl]naphthalene-1-ol, derived from 1-hydroxy-2-naphthaldehyde and 2-(1H-indol-3-yl)ethylamine, was used to produce a new sequence of metal ions complexes. Thus ligand reactions with NiCl2.6H2O, PdCl2, FeCl3.6H2O and H2PtCl6.6H2O were sequentially made to collect mono-nuclear Ni(II), Pd(II), Fe (III), and Pt(IV). (IR or FTIR), Ultraviolet Reflective (UV–visible), Mass Spectra analysis, Bohr-magnetic (B.M.), metal content, chloride content and molar conductivity have been the defining features of the composites. The Fe(III) and Pt(IV) complexes have octahedral geometries, while the Ni(II) complex has tetra
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