Back ground: Oral isotretinoin is recommended
for sever nodulocystic acne in the doses 0.5-
2mg/kg/day which is usually associated with higher
incidence of adverse effects. To reduce the
incidence of side-effects and to make it more costeffective,
the lower dose regimen of isotretinoin has
been used.
Aim: To compare the efficacy and tolerability of
oral isotretinoin 10mg and 20mg/day in acne
vulgaris.
Methods: one hundred and twenty patients with
acne vulgaris were randomized into two treatment
regimens each consisting of 60 patients. The first
was treated with 10mg/day and the second group
with 20mg/day for 24 weeks. Fifty five patients
from the first group and 47 patients from the second
group who continued the study for 24 week and 8
weeks after cessation of therapy. The response rate
was recorded in the form of acne load and acne
grade initially, during treatment and after 8 from
stopping treatment. Side effects were also recorded
in both groups.
Results: The response rate in both groups was
comparable in mild, moderate, and severe acne
vulgaris patients. Frequency and severity of
treatment-related side-effects were significantly
higher in the second group as compared to the first
group.
Conclusion: 10mg/dayisotretinoin can be used in
the treatment of mild, moderate and severe acne
with less side effects as compared to 20mg/day.
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Dairy wastewater generally contains fats, lactose, whey proteins, and nutrients. Casein precipitation causes the effluent to decompose into a dark, strong-smelling sludge. Fluid waste contains soluble organic matter, suspended solids, and gaseous organic matter, which cause undesirable taste and smell, grant tone and turbidity, and advance eutrophication, which plays an essential role in increasing biological oxygen demand (BOD) in water. It also contains detergents and disinfecting agents from the rinses and washing processes, which increase the need for chemical oxygen (COD). One of the characteristics of dairy effluents is their relatively high temperature, high organic contents, and wide pH range, so the discharge of wastewater into
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