Activation of farnesoid X receptor (FXR) markedly attenuates development of atherosclerosis in animal models. However, the underlying mechanism is not well elucidated. Here, we show that the FXR agonist, obeticholic acid (OCA), increases fecal cholesterol excretion and macrophage reverse cholesterol transport (RCT) dependent on activation of hepatic FXR. OCA does not increase biliary cholesterol secretion, but inhibits intestinal cholesterol absorption. OCA markedly inhibits hepatic cholesterol 7α‐hydroxylase (Cyp7a1) and sterol 12α‐hydroxylase (Cyp8b1) partly through inducing small heterodimer partner, leading to reduced bile acid pool size and al

New vision of Mr. Abdul Mahdi Al-Muttafiqi in the light of unpublished documents

This competition between competing forces, organized into axes with conflicting objectives, is reflected in all regional affairs and the goals and interests of countries within them, including Iraq. Among the most important aspects impacted by the repercussions of international and regional competition in the region is Iraqi national security, based on its vital importance in preserving the sovereignty and entity of the Iraqi state, protecting the interests and cohesion of the state and people, ensuring and defending their present and future, and interacting with various regional and international activities. The Kurdistan Region, as an important part of Iraq with its own unique characteristics, may be one of the most important regi

Abstract

The objective of this research is to identify the analysis of the ethics of the administration in the development of the social responsibility of one government organizations, and to achieve the objectives of the research was the use of a questionnaire developed for the purpose of data collection and distribution to the research sample, was chosen as a total sample population (50) individuals were relying on statistical package to do a statistical analysis for this research, user, ANSI (SPSS) simple regression analysis, standard deviation, Pearson correlation coefficient.

Research findings show the role of social responsibility in achieving the university's strategy,

The meteorite with a single total mass of 630 gm as a visible meteorite has fallen on 22 March 2021, at 10:00 a.m. in Al-Sherqat subdistrict within Salah Al-Din, northern Iraq; and therefore, was named Al-Sherqat meteorite by the authors. It is characterized by a uniform structure of coherent and medium degree of malleability. It is of a well-crystalline structure and not homogeneous in composition. The Al-Sherqat meteorite is composed of metallic phases of 7.6 gm/cm3 density exhibiting an oriented intergrowth of kamacite (α-FeNi) with taenite showing a Widmanstätten pattern on an etched polished section with the finest octahedrite kamacite bandwidth of less than 0.2 mm. It is composed of Fe (86.9 wt%), Ni (9.63 wt%), P (1.31 wt%)

تعد ظاهرة النخبة من اهم الموضوعات التي يعنى بها دارسو العلوم السياسية، اذ تشكل هذه الظاهرة محور نشاطات الجماعة السياسية، وبالرغم من تباين النظريات المتعلقة بتفسير وجود هذه الظاهرة ونشأتها، فان هناك اتفاقا على ارتباط هذه الظاهرة بتوزيع القوة داخل المجتمع الانساني فبعد ان كانت هذه الكلمة )النخبة( تستخدم في القرن السابع عشر لوصف سلع ذات تفوق معين امتد استعمالها فيما بعد ليشمل الاشارة الى فئات اجتماعية متفوقة ك

Şiiri şiir yapan öğlerin başında imge (hayal, tasavvur, imaj) gelir. İmgesiz şiir düşünülmez. İmge nedir?
İmge duyuyla elde edilen güzelliklerin, deneyimin dil aracıyla ortaya konulmasıdır. Şiiri şiir yapan sadece içeriği değil. Sunuluşu, imgelerin etkili bir biçimde kullanılışı, şairinin bu konudaki yetenek ve ustalığı, insana hitap etmesi, değişimlere açık oluşu, evrenselliği, kalıcılığı, sıra dışı güçlü anlatığına başvuruşu, söz sanatlarından yararlanması, öz anlatım biçimi, kimi zaman alışılmamış bağdaştırmaları bünyesinde barındırması ve sık sık da yinelemeler yardımıyla zengin anlatım aktarımıdır.
Biz bu çalışmamızda şiirde yalnızca imge

تعددت آراء المفكرين الاسلاميين المعاصرين حول الدولة الاسلامية بعد سقوط الخلافة العثمانية بصورة خاصة نتيجة لتأثر هؤلاء المفكرين بالمفاهيم التي سادت في الثقافة الغربية ، ومنها مفهوم الدولة ، حيث لم يتطرق الفكر الاسلامي الى مناقشة مفهوم الدولة الاسلامية قبل هذه الفترة ، لان اهتمامهم كان منصبا بالتظير حول موضوع السلطة . وسيتم التطرق في هذا البحث لمفهوم الدولة لدى المفكرين الاسلاميين المعاصر