background: osteoporosis is a metabolic bone disease that affects women more than men, it is characterized by generalizes reduction of bone mineral density (BMD) leaving a fragile weak bone that is liable to fracture, gonial angle index (GAI) is one of the radio-morphometric indices, it has been controversial whether it is related to bone mineral density or ageing or none of them. The aim of study is to evaluate the role of cone beam computed tomography (CBCT) as a screening tool for diagnosis of osteoporosis and age effect in females using gonial angle index. Material and method: 60 females were divided into 3 groups according to age and (BMD) status into: Group1 (non-osteoporosis 20-30 years), Group2 (non-osteoporosis 50years and above), and Group3 (osteoporosis 50years and above), each patient had a CBCT scan, and gonial angle index was measured compared among groups. Results: Gonial angle index showed a significant difference between Group1 and Group2 at p < 0.05, while it showed no significant difference between Group2 and Group3 at p > 0.05. Conclusion: Gonial angle index is significantly affected by age factor while it was not affected by osteoporosis, so it cannot be used as a parameter that can predict bone mineral density status patients
