Many conservative sphincter-preserving procedures had been described to be effective in
healing of anal fistula without excision or de roofing.
Objective: To verify the outcome of mere photocoagulation of the fistula tract on healing of low anal
fistula.
Materials and Methods: Using 810nm diode laser, the tracts of low anal fistulae in a cohorts of six male
patients (mean age of 32 yr) had been photocoagulated by retrograde application of laser light through an
orb tip optical fiber threaded in to the tract. Swabs for culture and sensitivity testing were obtained before
and after laser application. Patients were followed up regularly to announce fistula healing.
Results: Mean laser exposure time was 6.6 min., mean operative time was 19 min., mean hospital stay
was 5.9 hrs and mean fistula closure time was 7.7 days. The negative immediate post laser exposure
swabs indicate that laser may have a bacteria killing power. There were no evidences of incontinence or
recurrence within the mean follow up period of 9 weeks. The feasibility of using the selected laser and
accessory was excellent. The basic laser-tissue interaction was thermal photocoagulation without
carbonization.
Conclusions and Recommendations: Mere photocoagulation of the fistula tract may heal a low anal
fistula. Within the chosen parameters of laser application, there was no evidence of damage to the anal
sphincter. It is recommended that larger number of cases to be done to allow for proper statistical
analysis. High, complicated, and recurrent cases may be included. A longer follow up period to assess
intermediate and long term recurrences is recommended.
Attempts were made to improve solubility and the liquisolid technology dissolving of medication flurbiprofen. Liquisolid pill was developed utilizing transcutol-HP, polyethylene glycol 400, Avecil PH 102 carrier material and Aerosil 200 layer coating material. Suitable excipient amounts were determined to produce liquisolid powder using a mathematical model. On the other hand, flurbiprofen tablet with the identical composition, directly compressed, was manufactured for comparison without the addition of any unvolatile solvent. Both powder combination characterizations and after-compression tablets were evaluated. The pure drug and physical combination, and chosen liquisolid tablets were studied in order to exclude interacting with t
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From the results obtai
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