In diabetes, impaired wound healing and other tissue abnormalities are considered major concerns. Many factorsaffect the time and quality of wound healing. One of the purposes of medical sciences is wound healing in a short time withreduced side effects. The herbal products are more precious in both prophylaxis as well as curative in delayed diabetic woundhealing activity when compared to synthetic drugs.A wide range of evidence has shown that capers plant possesses differentbiological effects, including antioxidant, anticancer and antibacterial effects. Phytochemical analysis shows thatC. spinosahashigh quantities of bioactive constituents, including polyphenolic compounds, which are responsible for its health-promotingeffects. The healing response emerges subsequently to cells exposure to alarm signals once the skin barrier is disrupted. Thisresponse is ultimately commanded by growth factors (GFs), which act as soluble messengers, establishing a communicationnetwork among the different cells populations and with the extracellular matrix. EGF is produced by platelets, macrophages andfibroblasts and has a paracrine impact on keratinocytes. The expression of EGF at the wound site is highest during activeepithelialization and wound contraction and stimulates the development of granulation tissue.Assessment of immunohistochemicallocalization of EGFin skin wound treated byCapparis spinosa flavonoid extract in alloxan-induced diabetic rats.A total of 30healthy maleWistar rats weighing approximately 250-300 gm were used in this study. A surgical incisional wound with fullskin thickness of 1.5 cm length were done on facial skin of each rat, they were randomly divided into following groups: GroupA: (10 healthy rats) received daily local application of the plant extract. Group B: (10 alloxan-induced diabetic rats) receiveddaily local application of extract of the plant material. Group C: (10 alloxan –induced diabetic rats) where normal saline wasapplied locally instead of plant extract. Scarification of all animals was done for the healing periods (3 and 7 days), andspecimens were prepared for immunohistochemical analysis. The results revealed highest percentage of EGF stromal andepidermal expression noticed in groupA, and in group B respectively at day 7 withhighly significant differene between stromaand epiderms in groups B and C. Results obtained in this study showed that flavonoid rich extract ofCapparis spinosaenhanceswound healing process in diabetic rats (1) (PDF) IMMUNOHISTOCHEMICAL EVALUATION OF EPIDERMAL GROWTH FACTOR EXPRESSION IN SKIN WOUND TREATED BY CAPPARIS SPINOSA FLAVONOID EXTRACT IN ALLOXAN INDUCED DIABETES RATS. Available from: https://www.researchgate.net/publication/342881316_IMMUNOHISTOCHEMICAL_EVALUATION_OF_EPIDERMAL_GROWTH_FACTOR_EXPRESSION_IN_SKIN_WOUND_TREATED_BY_CAPPARIS_SPINOSA_FLAVONOID_EXTRACT_IN_ALLOXAN_INDUCED_DIABETES_RATS [accessed May 16 2023].
The glycated haemoglobin A1c(HbA1c) and Fasting blood glucose(FBG) effect on type1 diabetic pateints as a screening tests and as a gold standard for assessing glycemic control in subjects with diabetes were studied . Ninety one blood samples were collected in a peroid between June and the end of November 2012 at AL- Kindy Diabetic Center and Central Child Hospital,48 Females and 43 Males , aging between (11 month- 18 year), are divided into three groups, newly diagnosed , ongoing and healthy control group, with duration of disease between(1 day-3months) and (from birth-8 years) for newly diag
... Show MoreAbstract The condition known as gestational diabetes mellitus (GDM) describes as an intolerance to glucoseThat first occur or progresses during pregnancy is the most common metabolic illness, and impacts up to25% of pregnant women. It has been demonstrated that omentin-1, which originates from both human placental and adipose tissue can serve as an insulin resistance mediator. It was initially identified as a secretory factor specific to visceral fat and showed that recombinant omentin-1 administration increased insulin-stimulated glucose transport in vitro which may increase insulin sensitivity, both glucose and insulin can down regulate omentin-1 which reduces levels in overweight women with polycys
... Show MoreIn the present study, the effect of Zinc nanoparticles on levels of (T3 , T4 and TSH) hormones was investigated. Zinc nanoparticles were synthesized by Laser induced plasma.The Nd: YAG Nd: YAG laser with a wavelength of 1064 nm was used to generate nanomaterials of the elements (zinc) upon collision with target atoms. Plasma generated by different laser intensity is generated. After confirming the preparation of zinc nanoparticles, XRD, AFM was examined, and the effect of these substances on the thyroid gland (T3, T4, TSH) was observed for two doses of each component (1 ml / kg, 4 ml / kg) after conducting a cytotoxicity examination of the lymphocytes of the rats extracted from Rat spleen was 1.8% less toxic to zinc, and as noted The
... Show MoreThe present study aimed to investigate the possible production of Thioflavin T and the effect of NaCl concentrations and growth phases on the growth rate, doubling time and proline of C. saipanensis N. Hanagata (Scenedesmaceae, Shaerophleales). The alga was cultured in BG 11 medium and six NaCl concentrations were used in the experiments during different growth phases. The results have unveiled the presence of Triflavin T in the alga. The study results showed a growth rate decrease at all NaCl concentrations except in control treatment, while the doubling time, was recorded highest value (14 days) at the NaCl concentration of 0.08 M. The highest value of Proline (0.509 mg. Lˉ¹) was recorded at the treatment of 0.08 M of NaCl and recorded
... Show MoreThe achievements of the art that we know today are questioned in motives that differ from what art knew before, including dramatic artistic transformations, which he called modern art.
In view of the enormity of such a topic, its ramifications and its complexity, it was necessary to confine its subject to the origin of the motives of the transformations of its first pioneers, and then to stand on what resulted from that of the data of vision in composition and drawing exclusively, and through exploration in that, we got to know the vitality of change from the art of its time.
And by examining the ruling contemporary philosophical concepts and their new standards and their epistemological role in contemporary life, since they includ
The parasite Alchammannia Aaúlan Ahdma backbone and the other for Avgari and moves them alternately Vafiqra is Alannsan and Allbaún and other either Allavgari is an insect Aharms or sand fly of the genus deployed in the ancient world is different form the parasite and installed Albayukimaaúa in each of the Family is so when transmitted from host to another passes stages growth
Abstract
All central air conditioning systems contain piping system with various components, sizes, material, and layouts. If such systems in operating mode, the flow in piping system and its component such as valves can produce severe vibration due to some flow phenomenon’s. In this research, experimental measurements and numerical simulation are used to study the flow-induced vibration in valves. Computational fluid dynamics (CFD) concepts are included with one-way and two-way fluid-structure interaction concepts by using finite element software Package (ANSYS 14.57). Detection analysis is performed on flow characteristics under operation conditions and relations with structural vibration. Most of
... Show MoreIntestinal mucositis is referring to inflammatory or ulcerative lesions of the oral or gastrointestinal tract; one of the main reasons is treatment with cancer chemotherapy. The prodrug Irinotecan is converted by carboxylesterase to the active metabolite SN-38, conjugated by UGT enzyme to SN-38G and then deconjugated by ?-glucoronidase produced by intestinal bacterial flora to produce SN-38. Irinotecan induces intestinal mucositis and diarrhea due to increased concentration of its active metabolite (SN-38).To evaluate the protective effect of carvone, I.P injection of (75mg/kg/day) of irinotecan for 4 days to induce intestinal mucositis, carvone administered to mice orally for 6 days starting from day 1. Results showed that carvone (50mg
... Show MoreThe objectives of this study were to assess the potential of platelet-rich fibrin (PRF) on acceleration of soft tissue healing after tooth extraction and to evaluate its effectiveness in reducing the prevalence of dry socket among smoker patients. Twenty smoker male patients aged (18–72) years with multiple teeth extraction were participated in this clinical research. They underwent trans-alveolar extraction of 40 teeth. The extraction sockets were divided in each patient into 2 groups: the study group in which extraction sockets were treated with PRF and the control group: in which extraction sockets left to heal naturally without PRF. Platelet-rich fibrin enhan
Background:
Multiple sclerosis is a chronic disease believed to be the result of autoimmune disorders of the central nervous system, characterised by inflammation, demyelination, and axonal transection, affecting primarily young adults. Disease modifying therapies have become widely used, and the rapid development of these drugs highlighted the need to update our knowledge on their short- and long-term safety profile.
Objective:
The study aim is to evaluate the impact of disease-modifying treatments on thyroid functions and thyroid autoantibodies with subsequent effects on the outcome of the disease.
Materials and Methods:
A retro prospective study
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