Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death. Therefore, it is critical for researchers to understand molecular biology in greater depth. In several diseases including cancer, abnormal miRNA expression has been linked to apoptosis, proliferation, differentiation, and metastasis. Many miRNAs have been studied in relation to cancer, including miR-122, miR-223, and others. Hepatitis B and C viruses are the most important global risk factors for HCC. This study is intended to test whether serum miRNAs serve as a potential biomarker for both HCC and viral infections HBV and C. The expression of miRNA in 64 serum samples was analyzed by RT-qPCR. Compared to healthy volunteers, HCC patients' sera expressed significantly lower levels of miR-122 and miR-223. Furthermore, we compared the expression of these miRNAs between early-diagnosed HCC patients and healthy controls. There was a significant difference between miR-122 expression in HCC sera and healthy volunteers' sera (0.000 and 0.253, respectively), with a P value of <0.0001. Early diagnostic patients without treatment had completely deleted miR-122 expression levels, while those treated had slightly elevated levels. Clearly, miR-122 has been identified as a biomarker for early detection and follow-up of HCC treatment. HBV and HCV specimens expressed significantly lower levels of miRNA than normal samples with a P value of <0.0001. It is recommended that these findings be further investigated for diagnostic purposes. Further, these miRNAs are highly specific for diagnosing HCC, HBV, and HCV, making them valuable therapeutic indicators.
مشكلة البحث
إن طرائق تدريس المواد الشرعية ما تزال تُدّرس بطرائق لا تتناسب مع ما توصل إليه البحث العلمي في الميدان التربوي في الوقت الحاضر ، وهذا مما سبب في وجود أزمة فكرية وعلمية في الأقسام التي تدرس المناهج الدينية .
على الرغم من الأهمية الكبيرة لمادة التلاوة ، إلا أن هناك مشكلة كثيرا ما يعاني منها مدرسو هذه المادة، وهي انصراف الطلبة عن حفظ النصوص القرآن
... Show MoreThe performance evaluation had Focused for many years ago on The financial factors which are Not enough for the contemporary business organizations. So in order to get useful information it con used The balanced score card which can used to offer information about some measurement on which the level of the act actual performance is determined.
The purpose of this research is to suggest a model which may be used by law enforcement to broaden individual and organizational creativity while providing a more inclusive, holistic view of management within our internal and external organizational structures. This project introduces alternatives to traditional management, leadership styles and problem solving strategies. Law enforcement organizations in the 21st century will face many challenges. Much like community policing impacted the nation in the mid 1980's through the 1990's, the systems thinking approach offers a philosophy for the new millennium.
Most organizations will face many challenges in the next decade of the twentieth first century. Just
... Show Moreيتناول البحث دراسة مقارنة بين القوانين المدنية والقانون الانكليزي لسلطة المحكمة في تنفيذ الالتزام العقدي على حساب المدين
Dying poetry ,last felt the man to say apriorior improvisation during entry in to the
context of the death while going through it, or distracted by the death , before the soul went
out the duration of a brief may not exceed the minutes , with out pious or pen or vain , may
have been exercised in his daily life, compelled or for the benefit.
The discussion dealt with the meaning of dying, then presented its article with three
topics;
First; What was said in accepting the death.
Second; what was said in the reguest fo death.
Third; what was said to ignore the death.
This lesson as well as poetry style andcream and the imeanings and ideas and nages and
rhetorical rhythm. To achieve this, adopted solid sources a
In recent years, the attention of the international community and intergovernmental and non-governmental organizations has grown into a new dimension of population displacement, called displacement within the country as a result of conflicts and the expansion of tacit groups, using sentences to describe such conflicts as "identity-based conflict", "ethnic conflict" "Sectarian conflict", in an attempt to determine the nature and characterization of those conflicts. In such conflict-stricken conditions, the value of a citizen - a person not directly involved in the conflict - is measured by the potential gains that that person has made to the conflicting parties, as civilians have been indirect victims of military operations, Favor
... Show Moreالتعريف بالبحث
اهمية البحث والحاجة اليه :.
اللغة وظيفة اساسية الا وهي التواصل ولقد زدادت الحاجة في هذا العصر الى تعلم اللغات والاحاطة بها اكثر من اي وقت مضى يوصفها الاساس الذي يعتمد عليه في تعلم المواد الاخرى .
فاللغة اداة التفكير ونشر الثقافة في بلدان كثيرة مثل بلاد الاندلس التي اشرقت منها الحضارة في ا
... Show Moreيهدف البحث الى دراسة وتحليل التمويل الأخضر كأحد المفاهيم الاساسية والحديثة في عالم الاعمال والاقتصاد العالمي وخاصة بعد الازمات والتحديات التي توالت على العالم نتيجة الكوارث الطبيعة وتغييرات المناخ والضغوطات على الموارد الطبيعية والتي أدت الى احداث اثرا كبيرا في اقتصاديات الكثير من الدول ، مما اضطرت الى إعادة النظر في مشاريعها وانشطتها الاستثمارية بما يوائم وطبيعة البيئة ومتغيراتها ، لذا تحتم اختيار لمثل
... Show MoreThe research aims to identify the level of increase or decrease the product cost through the activity based flexible budgeting that gives us the chance to follows the cost since the product is planed to be made till it appears in the market and it also helps to fined out any problems that are expected to happen in the future and to put the costs under control, also to know much the surveying affects the perfect use for the complete resources in order to be used in the demanded way, the research is divided in to three sides ,the first is specialized for the theoretical side, the second is for the partical side, while the third side is specialized for the conclusions and recommendations.  
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