Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death. Therefore, it is critical for researchers to understand molecular biology in greater depth. In several diseases including cancer, abnormal miRNA expression has been linked to apoptosis, proliferation, differentiation, and metastasis. Many miRNAs have been studied in relation to cancer, including miR-122, miR-223, and others. Hepatitis B and C viruses are the most important global risk factors for HCC. This study is intended to test whether serum miRNAs serve as a potential biomarker for both HCC and viral infections HBV and C. The expression of miRNA in 64 serum samples was analyzed by RT-qPCR. Compared to healthy volunteers, HCC patients' sera expressed significantly lower levels of miR-122 and miR-223. Furthermore, we compared the expression of these miRNAs between early-diagnosed HCC patients and healthy controls. There was a significant difference between miR-122 expression in HCC sera and healthy volunteers' sera (0.000 and 0.253, respectively), with a P value of <0.0001. Early diagnostic patients without treatment had completely deleted miR-122 expression levels, while those treated had slightly elevated levels. Clearly, miR-122 has been identified as a biomarker for early detection and follow-up of HCC treatment. HBV and HCV specimens expressed significantly lower levels of miRNA than normal samples with a P value of <0.0001. It is recommended that these findings be further investigated for diagnostic purposes. Further, these miRNAs are highly specific for diagnosing HCC, HBV, and HCV, making them valuable therapeutic indicators.
ضمانات الاستثمار في حقول الغاز
Özet
Türkiye türkçesinde ''Anlam bilimi (Semantik)'' tezin ana konusu ve dilin adlandırma ve sınıflandırma incelemesini ele alır. Türk dilbilimcilerine göre bu dilbilimlerin şubesine bir tanım sunar. Semantik, tarih bakımından başlanlangıcı, oluşunu ve geliştirmesini de inceleniyor.
Bu konu ile ilgili yayınlanmış olan bazı tezlerin de alındı. Türk dilbilimcilerin görüşünu Mehmet Hengirmen, Konay Karaağaç, Sezai Güneş, Fuat Bozkurt ve Hüseyin Atay ve diğerlerdir.
Bu tez anlam bilimi dalların özellikleri ve anlam değiştirmesi
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RESUMEN:
Pretendemos hacer con este trabajo un breve recorrido sobre lo que han dicho algunos gramáticos de las construcciones condicionales, a la par señalaremos los criterios que los mismos establecen y siguen para diferenciar entre distintos tipos de estructuras condicionales o entre las construcciones que ellos entienden o consideran como tales y las que no, atendiendo fundamentalmente a dos criterios; formal y semántico-pragmático. El presente trabajo tiene como objetivo la clasificación y la descripción de las construcciones condicionales, demostrando que no todas las condicionales son hipotéticas ni todas las hipotéticas son condicionales.
Abstract
We intend to make this work
... Show Moreلا يتسع هنا المجال لأستعراض كامل الخلفيات التاريخية التي انتجت اوضاعنا الاجتماعية والاقتصادية والسياسية المتأزمة الحالية، وجل ما يمكن قوله هو ان الشعب العراقي وخلال ما يربو على ربع قرن لم يحصد سوى عدد من الحروب والعقوبات الدولية فالازمات التي ولدت الرعب والجوع المستمر للشعب حتى يومنا هذا.
لقد كان الاقتصاد الوطني اول واكبر المتضررين من تلك الازمات ومن سياسات الدولة غير العقلانية فكانت ال
... Show MoreTribute in Islamic economical system was considered one of the matters that took great importance where there put for it many jurisdictions that organize its work and the tribute was considered one of the permanent income for the state and the tribute had direct benefits for the life of the people where with the increasing differences in the
الواقعية في قصص يهوشاع كتان
Studying translation as academic article has cultural motive side by side academic aim to establish a professional generation that have the ability to serve labor market .
And because translation is important in many sectors in the society such as technology, science, popular institutions, tourism and political and legal relations between countries.
Our investigation concentrate on the articles of translation teaching in fourth class/ Spanish Department/ College of Languages/ Baghdad University for five years in order to evaluate the level of utility of creating translators and interpreters after graduation .
From 2009 until 2014 we saw continuous yearly exchanging in teaching articles by many professors with diff
... Show Moreتدريس العلاقات الدولية في العراق
Thank God thank so much good and blessing .sobhank dose not praise you، you also Praised on yourself، created Vobdat، and given culminated، there is no inventory of graces، nor limits to please، and pray and to recognize the honest slaves، and he finished your creation، senders ring، and a teacher، our Prophet who was Prophet Mohammed bin Abdullah (Al-Ameen)، the adviser.