Rheumatoid arthritis (RA), is an autoimmune, and inflammatory disease that is closely related to the destruction of cartilage and bone. DC-SIGN are important types of C-type lectin receptors (CLRs), expressed on dendritic cells and macrophages, and have a central role in regulating innate and adaptive immunity, function as pattern recognition receptors, and as cell adhesion molecules. Recent evidence has demonstrated that DC-SIGN is involved in the pathophysiological of chronic inflammation, so DC-SIGN has been linked to several autoimmune and may play an essential indicator in the pathogenesis and progression of RA. Therefore, the purpose of this study is to determine the serum level of DC-SIGN in RA patients, as well as the level of DC-SIGN based on demographic characteristics. Fifty Iraqi RA patients were enrolled in the study, and a control sample of 38 healthy individuals (ascertain by laboratory and clinical tests) were included and matched by gender, age, and ethnicity with the patients. The DC-SIGN concentration was calculated in the patients’ serum and compared to control using the ELISA assay and the results revealed significantly increased serum level of DC-SIGN (12.047 ± 1.114 vs. 6.863 ± 0.806 ng/ml) was recorded in RA patients compared to controls. When correlating results, it was shown that the concentration of DC-SIGN in the serum did not record a significant difference between gender and age, as well as the blood groups. To determine the impact of the therapeutic status in RA patients on the DC-SIGN level, it was found that the concentration of DC-SIGN level was higher in untreated patients compared to treated patients. Regarding viral infection, when an investigation was conducted in RA patients infected with SARS-CoV-2, the serum level of DC-SIGN in RA patients with COVID-19 showed no change in concentrations compared to uninfected RA patients.
اكتشافات النص الروائي واهميته في المعالجة والاخراج
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يتعلق موضوع بحثنا في الصلة بين القانون والاخلاق، إذ تكمن جوهر فكرة القانون عموما والجنائي بشكل أخص فهذا الاخير انما يتعامل اساسا مع صور المساس الاكثر خطورة بالمعايير الاخلاقية والقيم التي تستند اليها. ويتعلق الامر بعد ذلك بالحقائق الاجتماعية التي تؤكد وجود تباين ملحوظ في مستويات الالتزام الفردي والجمعي بتلك المعايير نتيجة للتغير والتغيير الاجتماعي السلبي او الايجابي فإذا جمعنا ذلك مع ثبات القانون النسبي ك
... Show Moreف هذه الدراسة إلى حثىظ هىةهالا ارابىاا وىي ر"ادىة ا فدىء اللاىدا ا رر،ىي ىة ا لأن هىىذه الهىىةهالا تأىىد" ضوحىىا "هىى اة وىىي هىىذه الا"ادىىة "ت حىى تیىىةرا طىىی الا ،ىى ي یةتهىىة "اتجةهةتهىىىىة اللا ااىىىىة "اللاةیىىىىة تة ىىىىة ضن ال ةتىىىى اسىىىىب ةم ضن دجطىىىىد هىىىىذه الهىىىىةهالا ال ث راىىىىة تجط دا وةیة ب زا "كشف ن طأیية اليلاقة ب ن ةلم ال اقع " ةلم الث،م لدى الشخصیةت " ىىىة تبطىىىم حىىىض ىىىن تةى
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Abstract
The twentieth century French novel had undergo a significant change that took the form of a radical move from the traditional son who follows his father to one who no way prevalent in the classical French novel. The new son in the 2Oth century novel finds himself emotionally attached which both became a new trend and approach in novel writing.
Marcel Proust's novel which can be considered a source of inspiration for most of 2Oth century novelists is a good example of the mother supremacy which is crystal clear from the first page through its parts and chapters till the last page. In fact, Proust had written a completely different novel from the Balzacian conventions. Unlike the latter's novels, Pro
... Show MoreThis study identified intellectual and applied research in key variables (Strategic Control and Strategic Pitfalls) through internal dimensions then founded the (Federal Board of Supreme Audit) is the good area for analyzing the relationship and effect between variables by (125) questionnaire selected from (148) was distributed to the top and middle management as a seniors in controlling action. Appropriate methods, statistical tools, and programs were used to enhance the basic outputs, represented as a set of Conclusions and recommendations from the real control work with a specificity of potential Pitfalls in the effectiveness impact by Strategic Control in other dimensions which Studied.
دور مكننة المعلومات المحاسبي في اتخاذ القرارات
Riding in Andalusia was a sport emphasized by Islam. It also works to strengthen the muscles, prevent them from sagging, gain vitality and vitality, regulate blood circulation and improve brain and heart function. The research we discussed in the study is not limited to a particular class. Most Andalusian rulers practiced equestrian And they hold concerts and competitions of horse competition, as happened during the reign of Caliph al-Hakam al-Mustansir and Muzaffar ibn Abi Amer and the governor adopted Ben Abbad and the Caliph Muhammad bin Bani al-Ahmar, the governor of the city of Granada in the presence of the great poets such as the son of Abu Salt and Ibn
... Show Moreتناولت هذه الدراسة نبات القريص واسمه العلمي Urtica dioica والمجهز من صيدلية الحضر ومن المعشب للتعرف على مكوناته الكيميائية واهم المجاميع الفعالة فيه . بينت هذه الدراسة احتواء النبات على القلويـدات ( alkaloids ) والتانينـات (Tannins ) والصابونيات ( Saponins ) وكانت الدالة الحامضية للمستخلص المائي للنبات المجهز من صيدلية الحضر متعادل بينما
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