Cytokines are signaling molecules between inflammatory cells that play a significant role in the pathogenesis of a disease. Among these cytokines are interleukins (ILs) 17A and 33, and accordingly, the current case-control study sought to investigate the role of each of the two cytokines in the risk of developing multiple sclerosis (MS). Sixty-eight relapsing-remitting MS (RRMS) Iraqi patients and twenty healthy individuals (control group) were enrolled. Enzyme linked immunosorbent assay (ELISA) kits were used to determine serum levels of IL-17A and IL-33. Results revealed that IL-17A and IL-33 levels were significantly higher in MS patients than in controls (14.1 ± 4.5 vs. 7.5 ± 3.8 pg/mL; p < 0.001 and 65.3 ± 16.3 vs. 49.3 ± 20.0 pg/mL; p < 0.001, respectively). Receiver operating characteristic (ROC) curve analysis demonstrated that IL-17A was a very good predictor of MS (area under curve [AUC] = 0.869; 95% CI = 0.779 - 0.960; p < 0.001; cut-off value = 10.2 pg/mL; sensitivity = 80.8%; specificity = 75.0%). A similar prediction was presented by IL-33, but the AUC value was lower (AUC = 0.762; 95% CI = 0.63 - 0.89; p < 0.001; cut-off value = 56.4 pg/mL; sensitivity = 70.6%; specificity = 70.0%). Multinomial logistic regression analysis confirmed the significance of IL-17A and IL-33 in MS risk, and under three models of analysis, the estimated odds ratios for IL-17A (1.50, 1.49 and 1.50, respectively) and IL-33 (1.05, 1.05 and 1.06) were above 1.0. Patients stratified by gender (male and female), expanded disability status scale (EDSS: < 3 and ≥ 3) or medication (pre- and post-medication) showed no significant differences in serum levels of IL-17A and IL-33 for each stratum. However, with regard to response to medication, it was found that responding patients showed significantly higher levels of IL-33 than non-responders (70.9 ± 12.2 vs. 57.2 ± 18.2 pg/mL; p = 0.018). This difference was not observed when considering IL-17A. Pearson correlation analysis between IL-17A and IL-33 revealed that both cytokines were not significantly correlated. In conclusion, the study indicated that IL-17A and IL-33 were up-regulated in serum of MS patients, and this up-regulation was not influenced by age, gender, EDSS or medication status, but the elevated level of IL-33 was more pronounced in patients who responded to medication.
Arabic humanity heritage had considered as a treasure of artistic, literary aspects, which is full of energies to embody investment by suitable historical ideology.
Theatre, art can be used, corresponded to make special essay reflecting a desire to establish cultural notification.
مشكلة البحث
ان التصميم هو توالد افكار عدت اساس له حيث انها اشياء لها معنى لامور اقتضت الايعاز باعداد هذه التصاميم، اما المصمم فهو الشخص الملم بمباديء واسس التصميم من اجل تنفيذ هذه الافكار بطرق علمية مدروسة، الا ان هناك سؤالا يطرح هل بالامكان لاي شخص ان يرسم فكرة تصميمية؟
الجواب هو نعم فالتصميم ليس مقتصرا على المصمم فحسب بل ان باستطاعة أي شخص ان يعبر عن ما بداخله من افكار سواء ك
... Show Moreناولت هذه الدراسة إحدى الشخصيات الأمريكية التي تأثرت بواقع السود. كان بوكر تاليافيرو واشنطن أحد الأمريكيين السود ، الذين ولدوا في ظل العبودية وتعرضوا للاضطهاد بعد إلغاء حقوق التصويت وإطلاق قوانين جيم كرو من قبل الولايات الجنوبية. ورأى واشنطن خلال عمليات إعادة الإعمار أحوال السود وكيف كانت معاناتهم قبل الحرب الأهلية في ظل ظروف العبودية التي شملت الإذلال ، والحرمان من حقوقهم المدنية والسياسية، فيما لم يختلف
... Show MoreDue to the importance of the word and because it is the basic building block from which speech is formed, it has become the subject of the attention of many scholars, ancient and modern
كانت االمثمة ومازالت الػسيمة الػحيجة واالىع في ايزاح القػاعج الشحػية قجيسا وحجيثا ، فالسثال ىػ الصخيقة التي بػاسصتيا يفيع الستعمع ما يخيج ان يػصمو السعمع ، فالذخح الكثيخ والدخد ال يػصل الى بيان القاعجة مالع يعدز باالمثمة . وليحا فان اختيار السثال السشاسب في السكان السشاسب ال يتع بصخيقة عذػائية اذا يشبغي ان يكػن السثال ذا معاييخ ومػاصفات تشاسب السقام الحي قيمت فيو . مغ ىشا جاء ىحا البحث ليبيغ ما السػاصفات الت
... Show MoreThis study aimed to investigate the relationship between narcissistic
personality and altruistic behavior for a subject of (307) gifted high schools
students, including (139)male and (168) female students ,both the scale of
narcissistic personality and the scale of altruistic behavior (Hameed ,2002) were
checked for its validity and reliability ,and both the level of narcissism and the
level of altruism for the students were measured in compare to the medium average
and approved to be statistically significant at (0.05) level.
Results showed that there were no significant differences in the altruistic
behavior between males and females ,results showed significant differences in
narcissism levels between males a
The scientific abandonment of the most important places of education and science in the Happy Yemen, which Manfred them from the rest of the Islamic Alomassar such kind of places Education existence, has contributed to a variety of factors paved the way for the emergence and originated scientific migration in the (fifth century AH / atheist century AD), and was in the forefront divisions witnessed by the Zaidi sect to if divided into three teams are (Almpartyah and inventor and Husseiniya) Because of differences doctrinal debates Pima including a heated end the fighting of the conflict between the parties,
When we study the history of dentistry we can investigate some methodology styles which lead us to psychology – dentistry or take the relationship between psychology and dentistry, and this type of specialization which is Medical psychology has its own methodology and subjects, as the historical sequence in this filed lead to how evolution occurred in this branch of medicine, which was accompanied by many factors , and this factor that contributed to the consolidation of the misconceptions about the social, family and the media culture and gave a distorted picture of Dentistry and the attending physician or dentist and show him as someone tough , ruthless and violent in his dealings and style , these pro
... Show Moreمما توصل إليه البحث :
إن الدوافع النفسية تنفرد في تجسيد الأحاسيس والمشاعر في نتاج الشاعر , من خلال رؤيته لتلك الحالة , فتسهم في صورة المقارنة في التشبيه , فتبعث في المتلقي حالة التأمل والمقارنة بين الحالتين اللتين تجمع بين مكوناتهما صفة واحدة فتصل إلى حالة التلاحم , ويكون ذلك باعثا لرسم صورة التشبيه ال
... Show More