Cytokines are signaling molecules between inflammatory cells that play a significant role in the pathogenesis of a disease. Among these cytokines are interleukins (ILs) 17A and 33, and accordingly, the current case-control study sought to investigate the role of each of the two cytokines in the risk of developing multiple sclerosis (MS). Sixty-eight relapsing-remitting MS (RRMS) Iraqi patients and twenty healthy individuals (control group) were enrolled. Enzyme linked immunosorbent assay (ELISA) kits were used to determine serum levels of IL-17A and IL-33. Results revealed that IL-17A and IL-33 levels were significantly higher in MS patients than in controls (14.1 ± 4.5 vs. 7.5 ± 3.8 pg/mL; p < 0.001 and 65.3 ± 16.3 vs. 49.3 ± 20.0 pg/mL; p < 0.001, respectively). Receiver operating characteristic (ROC) curve analysis demonstrated that IL-17A was a very good predictor of MS (area under curve [AUC] = 0.869; 95% CI = 0.779 - 0.960; p < 0.001; cut-off value = 10.2 pg/mL; sensitivity = 80.8%; specificity = 75.0%). A similar prediction was presented by IL-33, but the AUC value was lower (AUC = 0.762; 95% CI = 0.63 - 0.89; p < 0.001; cut-off value = 56.4 pg/mL; sensitivity = 70.6%; specificity = 70.0%). Multinomial logistic regression analysis confirmed the significance of IL-17A and IL-33 in MS risk, and under three models of analysis, the estimated odds ratios for IL-17A (1.50, 1.49 and 1.50, respectively) and IL-33 (1.05, 1.05 and 1.06) were above 1.0. Patients stratified by gender (male and female), expanded disability status scale (EDSS: < 3 and ≥ 3) or medication (pre- and post-medication) showed no significant differences in serum levels of IL-17A and IL-33 for each stratum. However, with regard to response to medication, it was found that responding patients showed significantly higher levels of IL-33 than non-responders (70.9 ± 12.2 vs. 57.2 ± 18.2 pg/mL; p = 0.018). This difference was not observed when considering IL-17A. Pearson correlation analysis between IL-17A and IL-33 revealed that both cytokines were not significantly correlated. In conclusion, the study indicated that IL-17A and IL-33 were up-regulated in serum of MS patients, and this up-regulation was not influenced by age, gender, EDSS or medication status, but the elevated level of IL-33 was more pronounced in patients who responded to medication.
This search modest deviation personal than to doubt that the event was not guilty by nature or offenders of evil in origin but is arictim of misfortune that makes him grow or live in the center of the corruption, even if he could be in the middle of the blessing of good and virtue and reform lived living righteousness and honor it was a useful member for himself and his community and must state and family community take hands mnhrfaite in order to prevent and provide then
اسلوب الحوار في القرآن الكريم اسلوب حياة وفي حقيقة الامر يضم القرآن الكريم بين دفتيه حوارات كثير مابين الله عزوجل وخلقه وما بين الانبياء واقوامهم وما بين الانبياء والطواغيت ومابين المؤمنين والكفار وهكذا ، وبدء الخلق قام على حوار مابين الله عزوجل وآدم وما بين آدم وابليس وما بيا الله جل وعلا والملائكة .
The current study aimed to know the reasons for the reluctance of
students to apply mathematics department in the Iraqi
universities. In order to achieve the objective of the study the
researchers a tool numbers of 4 - axes included 40 - paragraph,
distributed as follows:
- Set the first axis causes that relate to the student, the 14
paragraph.
- The second axis includes clauses concerning teacher and the
number of paragraphs of Article 9, paragraph.
- Axis III contains clauses concerning the nature of mathematics
and a number of paragraphs 11 paragraphs.
- The fourth, which included reasons related to classmates and
close and the number of paragraphs 6, paragraph.
The resolution offered on a group
The use of story to convey educational content which serves particular purposes is common use long ago, such as we see in Quran`s stories and bible stories which consider good examples, therefore the story individuates by this mission which has magnificent influence minds of the readers.
The Hasidic story is one of Hebrew literature affluents from it`s outset, therefore it has distinctive role in spread thoughts and principles which comes and believes it the Hasidic movement which considers reformatory Jewish religious movement. It aims to reforms the Jewish individual avvording to it`s vision and thoughts.
This paper research contains an introduction which presets s
... Show Moreبينت النظريات والمناهج النقدية الحديثة بعد تفعيلها لوسائل قراءة النص وتحليل عناصره وبيان وسائل تماسكه وروابطه فضلا عن تمثيله لمضامين مركزية ودلالات فرعية ان النصوص التراثية بوصفها نصوصا كاملة لسمات النص المؤثر قابلة للحضور في مجال المعرفة وفق تصور حديث يختلف عن تصور منتجهامنهجيا كما اتضح مدى عمق هذه النظريات والاسس التي ارساها بلاغيو العرب التي كانت ولاتزال محط انظار كبار النقاد وباحثي البلاغة.
The shortcomings of the Muslim regime were however, became more obvious in later periods. Under the first Abbasids, the Muslims bourgeoisies were still a new class, rising in the social hierarchy of the caliph empire. It became even powerful class and a factor to reckon with
التنظيم القانوني للمهني – دراسة مقارنة في نطاق الاعمال التجارية
Of good reasoning (the art of unique moral turn him poets of Andalusia in
poetry verse emitter myself, and to achieve a very technical. Either the emitter is
related to the nature of the environment and the composition of personal Andalusia
of appetite for life and interaction with the legibility beautiful, and it was (wit)
feature in them even said they are charming as Bagdad ions , and either art, it made
them this color to show their ability intellectual in the search for bugs, and
stimulate their imaginations in a contract equations in the interpretation and find
justifications for the ideas and meanings Exaggeratedly times, and especially in the
purpose of praise, and novelty in many cases, as in the spinning
اهتمام العلماء العرب بالحروف مبينين معانيه موضحين مقاصده