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bsj-6431
Predictive Significance of Interleukins 17A and 33 in Risk of Relapsing–Remitting Multiple Sclerosis
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Cytokines are signaling molecules between inflammatory cells that play a significant role in the pathogenesis of a disease. Among these cytokines are interleukins (ILs) 17A and 33, and accordingly, the current case-control study sought to investigate the role of each of the two cytokines in the risk of developing multiple sclerosis (MS). Sixty-eight relapsing-remitting MS (RRMS) Iraqi patients and twenty healthy individuals (control group) were enrolled. Enzyme linked immunosorbent assay (ELISA) kits were used to determine serum levels of IL-17A and IL-33. Results revealed that IL-17A and IL-33 levels were significantly higher in MS patients than in controls (14.1 ± 4.5 vs. 7.5 ± 3.8 pg/mL; p < 0.001 and 65.3 ± 16.3 vs. 49.3 ± 20.0 pg/mL; p < 0.001, respectively). Receiver operating characteristic (ROC) curve analysis demonstrated that IL-17A was a very good predictor of MS (area under curve [AUC] = 0.869; 95% CI = 0.779 - 0.960; p < 0.001; cut-off value = 10.2 pg/mL; sensitivity = 80.8%; specificity = 75.0%). A similar prediction was presented by IL-33, but the AUC value was lower (AUC = 0.762; 95% CI = 0.63 - 0.89; p < 0.001; cut-off value = 56.4 pg/mL; sensitivity = 70.6%; specificity = 70.0%). Multinomial logistic regression analysis confirmed the significance of IL-17A and IL-33 in MS risk, and under three models of analysis, the estimated odds ratios for IL-17A (1.50, 1.49 and 1.50, respectively) and IL-33 (1.05, 1.05 and 1.06) were above 1.0. Patients stratified by gender (male and female), expanded disability status scale (EDSS: < 3 and ≥ 3) or medication (pre- and post-medication) showed no significant differences in serum levels of IL-17A and IL-33 for each stratum. However, with regard to response to medication, it was found that responding patients showed significantly higher levels of IL-33 than non-responders (70.9 ± 12.2 vs. 57.2 ± 18.2 pg/mL; p = 0.018). This difference was not observed when considering IL-17A. Pearson correlation analysis between IL-17A and IL-33 revealed that both cytokines were not significantly correlated. In conclusion, the study indicated that IL-17A and IL-33 were up-regulated in serum of MS patients, and this up-regulation was not influenced by age, gender, EDSS or medication status, but the elevated level of IL-33 was more pronounced in patients who responded to medication.

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Publication Date
Thu Dec 13 2018
Journal Name
Arab Science Heritage Journal
اهمية أهمية التوثيق في المحافظة على الموروث البغدادي
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    Much has been written about Baghdad in the history books and documents ,about the Origin  of its call , Reality ,history ,peoples ,Rulers and  all that have passed since  the beginning of creation and so far...

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Publication Date
Thu Feb 07 2019
Journal Name
Journal Of The College Of Education For Women
الانفتاح الدلالي في الخطاب الشعري الحدیث (اللیل انموذجاً)
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This research deals with the idea of how the poetic reading can be a
rich field for producing the potential meanings in each text, through observing
the connection of the words and their link with other, thus composes, from the
collection of these interlaced meanings, what is called the poetic significant
(Symbolic) elaboration which deals with the reader of the text by regarding
him as a producer not as a consumer who can read a conscious reading, and
be diligent to solve the problem of the links of the relations among the
inspiring words because the language of poetry is an inspired language which
is capable of diversity and multiplicity of readings which is called the Symbolic
elaboration.

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Publication Date
Mon Oct 22 2018
Journal Name
Arab Science Heritage Journal
مبادئ مبادئ التعامل مع المشركين في السيرة النبوية
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Prophecy in general, and Muhammadism in particular, can not seem to go away from life, or lag behind it, because it was originally for reform. It can not succeed in achieving this reform. It has grown away from it, and its conditions have not caused it to vary and diversify. These conditions, from its origin to its tranquility, its stillness and its movements, are based on a wise divine workmanship and a strict divine planning that suits the performance of this personality

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Publication Date
Sun Jan 02 2005
Journal Name
Political Sciences Journal
واقع ومستقبل الصراعات الدولية والاقليمية في البحر الاحمر
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واقع ومستقبل الصراعات الدولية والاقليمية في البحر الاحمر

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Publication Date
Thu Oct 25 2018
Journal Name
Journal Of Planner And Development
تلوث الهواء داخل المباني واثره في صحة الشاغلين
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Publication Date
Sat Oct 01 2016
Journal Name
Journal Of Educational And Psychological Researches
فلسفة المناهج الجغرافية في تشخيص ومعالجة المشكلات البيئية
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It has become the subject of the environment and its problems during the last three decades of the important topics and dangerous that gained the attention of researchers in this regard as especially with the worsening repercussions severe, and turned out to be hot issues impose themselves urgently everywhere in the world, not concerned with the environment and specialists out, but also on all people wherever they are, regardless of their standard of living, and the circumstances of their lives, and their level of education and culture because the relationship of man with environment relationship since antiquity as relied upon to provide what they need him to stay, and through the stages of the development of civilization has made some a

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Publication Date
Tue Jan 08 2019
Journal Name
Arab Science Heritage Journal
تطور التعليم العالي في مدينة بغداد 1908-1957
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من المتفق عليه أن هناك طريقا واحدا لنشر الثقافة والقضاء على الجهل هو التعليم .ولعل أبرز ماشهدته مدينة بغداد من تطور هو ظهور المدر سة ومن ثم إنتشارها بشكل كبير وفق المفهوم الحديث مما أثرفي عموم الحياة اليومية ، ومن ضمنها التعليم العالي .إن الإستقرار من أهم ماتحتاجه الجامعة للقيام بواجباتها ولايأتي الإستقرار إلا بالإستقرار الذي يضمن لنا أن تكون الجامعة بعيدة عن ما قد يستجد من الأهواء و النزاعات.

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Publication Date
Mon Nov 19 2018
Journal Name
Arab Science Heritage Journal
التأثير التأثير الحضاري للأندلس في عهد الفونسو العاشر
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The Spanish King Alfonso X could deliver mane Andalusia culture to Europe, but it is the subject of our research, we decided to give a brief overview of his life.

This king March was politically different from the rest of the Spanish kings, which is opening up to the literature and Eastern thought, it is the.

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Publication Date
Wed Jan 07 2009
Journal Name
Political Sciences Journal
السياسة في الفلسفة الاسلامية : الفكر السياسي عند الفارابي
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السياسة في الفلسفة الاسلامية : الفكر السياسي عند الفارابي

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Publication Date
Thu Nov 08 2018
Journal Name
Arab Science Heritage Journal
مفهوم مفهوم التوليف في الخزف بين التراث والمعاصرة
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Interested in current research examining the concept of synthesis in contemporary ceramics, he studied the synthesis as a concept to achieve technical and aesthetic innovation.

The study comes in four axes. The first axis to ensure the general framework for research, containing the problem, which is to ask the following: Is the concept of synthesis role in enriching the contemporary ceramic done? The importance of research and study are needed in addition provide knowledge in the field of contemporary art

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