Cytokines are signaling molecules between inflammatory cells that play a significant role in the pathogenesis of a disease. Among these cytokines are interleukins (ILs) 17A and 33, and accordingly, the current case-control study sought to investigate the role of each of the two cytokines in the risk of developing multiple sclerosis (MS). Sixty-eight relapsing-remitting MS (RRMS) Iraqi patients and twenty healthy individuals (control group) were enrolled. Enzyme linked immunosorbent assay (ELISA) kits were used to determine serum levels of IL-17A and IL-33. Results revealed that IL-17A and IL-33 levels were significantly higher in MS patients than in controls (14.1 ± 4.5 vs. 7.5 ± 3.8 pg/mL; p < 0.001 and 65.3 ± 16.3 vs. 49.3 ± 20.0 pg/mL; p < 0.001, respectively). Receiver operating characteristic (ROC) curve analysis demonstrated that IL-17A was a very good predictor of MS (area under curve [AUC] = 0.869; 95% CI = 0.779 - 0.960; p < 0.001; cut-off value = 10.2 pg/mL; sensitivity = 80.8%; specificity = 75.0%). A similar prediction was presented by IL-33, but the AUC value was lower (AUC = 0.762; 95% CI = 0.63 - 0.89; p < 0.001; cut-off value = 56.4 pg/mL; sensitivity = 70.6%; specificity = 70.0%). Multinomial logistic regression analysis confirmed the significance of IL-17A and IL-33 in MS risk, and under three models of analysis, the estimated odds ratios for IL-17A (1.50, 1.49 and 1.50, respectively) and IL-33 (1.05, 1.05 and 1.06) were above 1.0. Patients stratified by gender (male and female), expanded disability status scale (EDSS: < 3 and ≥ 3) or medication (pre- and post-medication) showed no significant differences in serum levels of IL-17A and IL-33 for each stratum. However, with regard to response to medication, it was found that responding patients showed significantly higher levels of IL-33 than non-responders (70.9 ± 12.2 vs. 57.2 ± 18.2 pg/mL; p = 0.018). This difference was not observed when considering IL-17A. Pearson correlation analysis between IL-17A and IL-33 revealed that both cytokines were not significantly correlated. In conclusion, the study indicated that IL-17A and IL-33 were up-regulated in serum of MS patients, and this up-regulation was not influenced by age, gender, EDSS or medication status, but the elevated level of IL-33 was more pronounced in patients who responded to medication.
نطاق حماية المستهلك في القطاع المصرفي
Введение
Международные контакты обусловили интерес к изучению основной формы общения – диалога. Форма диалога в каждом из контактирующих в процессе общения языков должна быть рассмотрена в разных аспектах – не только лингвистическом, но и социолингвистическом и этическом. Это объясняется тем, что в речевой коммуникации необходима как адекватность выражения мысли, так и соблюдение тради
... Show Moreدراسة طبيعة الاستراتيجية الامريكيه في اقليم جنوب آسيا وصراعات القوى الإقليمية الهند وباكستان
حظيت التربية والتعليم برعاية كبيرة في المجتمع العربي الاسلامي عامة والعصر الراشدي بشكل خاص ونزلت الايات القرأنية الكريمة التي تناولت مفردات العلم والتعليم ومنها قوله تعالى : " وانزل الله عليك الكتاب والحكمة وعلمك ما لم تكن
Sustainable architecture in the thought of Sheikh Baha'i Sheikh Bahaa Al-Din is Muhammad bin Al-Hussein bin Abd Al-Samad bin Muhammad bin Ali bin Al-Hussein bin Saleh Al-Harthy Al-Hamdani Al-Amili Al-Jaba’i, a resident of Isfahan. And the mathematical and astronomical arts, and success was written for him in his writings, so it spread and was accepted by learned scholars in the last four centuries. Research from his activity and science is the engineering and architectural aspect.
Spiritual training is aimed to plant the faith in individuals soul because it is the basis of the religion, but rather a strong deferent that accompanies human life in his thinking and management and awakens
The goal of the research is to identify prevailing values in Kurdish children’s stories, and statistically significant differences between groups. In the theoretical framework, the definitions of values are reviewed. Furthermore, a range of previous studies were offered, with the most important findings.
To achieve the goals of this research, an amount of 14 Kurdish children’s must be analyzed. The selected Kurdish children’s stories must be translated to Arabic conform the classification ’White’. After confirming the stability of this tool, the researcher reached the following results:
The cognitive and physical values received the highest ratios, while the moral, practical, patriotic and nationalistic values
... Show MoreThe bourgeoisie groups derived great advantages from the system upon which the Fatimids built up their Regime out the land-tax and other taxes against a fixed sum . The surpulus revenue was the prophet of the farmers . A striking feature of the Fatimid was freedom of enterprise .All sectors of economic life were free-crafts , industry and trade . The government interfered in the trade in victuals only so far to in order to guarantee the supply of wheat to the big towns
The Egyptian Bourgeoisie enjoyed also the great prosperity which was produced among other reasons by the inflationary system of Fatimid economy .
The maintenance of gold dinar being almost pure and of full weight was only possible because Egypt steadily received cons