Zerumbone is a well-known compound having anti-cancer, anti-ulcer, anti-inflammatory and anti-hyperglycemic effects. During its use for the disease treatment, the membrane of erythrocyte can be affected by consumption of this bioactive compound. The current study was the first report of investigation of the hemolytic activities on human erythrocytes and cytotoxic profile of zerumbone. The toxicity of zerumbone on human erythrocytes was determined by in vitro hemolytic assay. Brine shrimp lethality assay was used to evaluate the cytotoxic effect of zerumbone at concentrations 10, 100 and 1000 μg/mL. The human erythrocyte test showed no significant toxicity at low concentrations, whereas hemolytic effect was amplified up to 17.5 % at the highest concentration. The half lethal concentration (LC50) value of zerumbone against brine shrimp was less than 1000 µg /mL (LC50=190 µg/ml) showing the significant toxic nature of this compound. These results provide a baseline in terms of the toxicity of therapeutic formulations from this compound to membrane erythrocytes with a great attention to the highest concentrations, which paves promise for drug development.
إدارة المخاطر في الوحدات الإقتصادية الصناعية بإستعمال مخطط باريتو
ملامح من فكرة القانون الطبيعي في حضارة العراق القديم
تم ت داول مصطلح الأزمة ا دلولية في السياسية ا دلولية خال القرن التاسع عش ر لتحدي دا ملدة الانتقالية بين السلم والحرب سواء أ دت الأزمة إلى نشوب صراع مسلح أم مت ت ت سويتها بالطرق السلمية، وتع دالأزمة ا دلولية مرحلة مت هيدية ل لحرب وهي ا رملحلة التي يسعى فيها أ طرا فالأزمة إلى إبعاد احتمالية نشوء أ و اندلاع الحرب، فالأزمة ه ي مدة حرجة ومرحلة خطيرة بين وقتي السلم والحرب، إن العلاقات ا دلولية تكاد ت عيشأ زمات متلاحقة ع
... Show MoreStill Financial institutions, including banks, a key target for money launderers to transfer illicit funds to the legitimate funds and by weaknesses in the internal audit procedures applied in the banks or through a lack of legal structure to combat this phenomenon in addition to the procedures by other regulations
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... Show MorePsychological Counseling Services occupies a high position in the developed countries and that for its psychologist services for different sectors of the community members, and has been popularized until recently the wrong concept of the effect, that the psychological service is provided only to the owners of behavior is normal only, Vantage him neglect to provide psychological services a large segment of the community members who are in dire need of these services.
The counseling service is part of a global social movement seeking to emphasize the quality of life of the human and the emphasis on the value and dign
... Show MoreSeemed reflections of cultural globalization are clear on the values of communities those values that preserve each community privacy, so that became members of these communities lack the ability to distinguish clearly between what is right and what is wrong and adoption of ideas and values imported from abroad, regardless of whether positive or negative. The aim of the research was to: - 1 - Detection of cultural globalization in the educational values for students kindergarten section. 2 - To identify the most prominent educational values (social, scientific, aesthetic, moral and spiritual) globalized culture. The current Aqtsralbges on: - Department of kindergarten students to study in the morning College for Girls, Baghdad University
... Show MoreAbstract Since unmethylated CpG motifs are more common in DNA from bacteria than vertebrates, and the unmethylated CpG motif has recently been reported to have stimulatory effects on lymphocytes, we speculated that bacterial DNA may induce inflammation in the urinary tract. To determine the role of bacterial DNA in lower UTI, we intraurethrally injected prokaryotic DNA (extracted from E. coli) in white mice and performed histopathological study for the kidneys and urinary bladders, 24 h after the exposure. The results showed infiltration of inflammatory cells, shrinkage of glomerulus and increase the capsular space, as well as edema formation in kidney tissues. Moreover, urinary bladder sections showed infiltration of inflammatory cells.
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