Zerumbone is a well-known compound having anti-cancer, anti-ulcer, anti-inflammatory and anti-hyperglycemic effects. During its use for the disease treatment, the membrane of erythrocyte can be affected by consumption of this bioactive compound. The current study was the first report of investigation of the hemolytic activities on human erythrocytes and cytotoxic profile of zerumbone. The toxicity of zerumbone on human erythrocytes was determined by in vitro hemolytic assay. Brine shrimp lethality assay was used to evaluate the cytotoxic effect of zerumbone at concentrations 10, 100 and 1000 μg/mL. The human erythrocyte test showed no significant toxicity at low concentrations, whereas hemolytic effect was amplified up to 17.5 % at the highest concentration. The half lethal concentration (LC50) value of zerumbone against brine shrimp was less than 1000 µg /mL (LC50=190 µg/ml) showing the significant toxic nature of this compound. These results provide a baseline in terms of the toxicity of therapeutic formulations from this compound to membrane erythrocytes with a great attention to the highest concentrations, which paves promise for drug development.
Bekanntlich hat jede Sprache ihre eigenen charakteristischen Besonderheiten. Davon ausgehend gibt es auch gewisse Unterschiede zwischen dem Arabischen und dem Deutschen. Zu den wichtigsten Gebieten der deutschen Grammatik gehören die zusammengesetzten Sätze, vor allem Satzgefüge mit den über- und untergeordneten Sätzen. Dazu gehören auch die Äquivalente der Nebensätze, besonders die Infinitiv- und Partizipialkonstruktionen.
Die vorliegende Recherche hat eine der grammatischen Strukturen des Arabischen und des Deutschen nämlich die dass-Sätze und Infintivsätze mit zu und deren Wiedergabemöglichkeiten in den beiden Sprachen zum Inhalt, weil die Infinitivsätze mit zu den Deutschlernenden beson
... Show MoreAssyrian merchants established in the second millennium BC Assyrian commercial settlements in Anatolia, and these settlements had a great cultural value
البنية الاقتصادية الاجتماعية للادارة الجديدة في الولايات المتحدة الامريكية
In this research, the problem of ambiguity of the data for the project of establishing the typical reform complex in Basrah Governorate was eliminated. The blurry of the data represented by the time and cost of the activities was eliminated by using the Ranking function and converting them into normal numbers. Scheduling and managing the Project in the Critical Pathway (CPM) method to find the project completion time in normal conditions in the presence of non-traditional relationships between the activities and the existence of the lead and lag periods. The MS Project was used to find the critical path. The results showed that the project completion time (1309.5) dinars and the total cost has reached (33113017769) dinars and the
... Show MoreViolence can be identified as an outreaching on others’ dignity,
freedom, properties, and life. Therefore, violent actions cannot be determined
only on materialistic attacks such as killing, beating, robbery, rape, and civil
wars, but it also includes the verbal attacks such as insult, threat, and cursing.
Violence against women can be identified as any bad actions that are
done against women, which lead to a physical or psychological harm, and
invade their safety and freedom whether these actions come from men or
women, against one woman or a group of women in special and general
places.
Before, the social, historical and lawful manners concentrated on
sexual distinction between the men and a woman, which
اهتمام العلماء العرب بالحروف مبينين معانيه موضحين مقاصده
شَهِدَت منطقة الخليج العربي والسَّاحِل العُماني تصاعد مُستوى الحِراك الشعبي، والمُطالبات بتحقيق الاِستقلال التام، وإنهاء الاِلتِزامات والاِرتِباطات الدولـيَّة سواء كانت في إطار الحِماية أو الاِستِشارة أو الصِّداقة، وأصبحت واجِهات ملحوظة من قِبل الفِئات المُـثـقَّـفة في بدايات العقد الثاني من القرن العشرين، وعبَّرت فيها القِوى الوطنيَّة عن حاجاتها في إجراء عملـيَّات التغيير والتحوّل الاِجتِماعي وعلى
... Show Moreالحركات الاسلامية في ظل الوضع الدولي الجديد
مثل الوعي الطبقي اعلى مراحله لدى الفكر الماركسي المعاصر عند كل من روزا لوكسمبورغ وانطونيو غرامشي، ليس مجرد انعكاس للواقع وانما يكون بصورة جدلية من طريق انعكاس الوعي على الواقع وإعادة انتاجه فبعد ان كان الوعي هو نتاج تطور الواقع اصبح أداة في تطوير الواقع، أي تأثير البنى الفوقية في البنى التحتية (المادية التاريخية) وعدت ان الوعي الطبقي الثوري يتحقق بشكل عفوي، وبذور انطلاقة هي الاضرابات الجماهيرية، وأنكرت دور
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