Rheumatoid arthritis (RA) is a systematic autoimmune disorder with chronic inflammation changes of unknown etiology. Various synovial inflammatory and proliferative alterations may contribute to the cartilaginous tissues and invasive bony tissues, leading to destructive joints and malformed bones. This disease is mostly due to infective microorganisms or genetic susceptibility causing immune system disturbances through triggering both T-cells and B-cells. Furthermore, different immune cells may secret cytokines, which are responsible for some RA pathogenesis activity. From ninety individuals, serum sample was collected; thirty of them were normal and sixty cases were patients with RA attended a privet medical clinic at Tikrit city from May 2019 to November 2019. Age, in both patients and control groups, ranged between (18-50) years, they had assay of Interleukin-1 (IL-1), Interleukin-6 (IL-6), Interleukin-10 (IL-10), Tumor necrosis factor (TNF)-α, Leptin, Adiponectin, and C-reactive protein. The present study shows that (IL-1, Leptin, and CRP) levels were higher in Rheumatoid Arthritis patients than control, while (IL-6, IL-10, TNFα, and ADP) levels were lower; therefore, cytokines can play an essential role in RA pathogenesis. The current study may bring attention to adiponectin and leptin for their roles in the pathogenesis of RA. Special consideration was devoted to those proteins, which act on cells associated with RA, also for possible usage of these protein levels as potential biomarkers for the disease activity and therapeutic response.
Ifosfamide (IFO), an alkylating chemotherapy agent, is known for its association with neurotoxicity and encephalopathy. This trial was designed to evaluate the protective action of daidzein (DZN) against IFO-induced neurotoxicity in male rats by determining the difference in certain inflammatory and apoptotic markers in the brain tissue of rats. Twenty-eight Wistar rats, weighing 120-150 g, were divided into four groups of seven rats: Group 1 (Control) received no treatment; Group 2 was orally administered DZN (100 mg/kg/day) for seven days; Group 3 received a single intraperitoneal (IP) dose of IFO (500 mg/kg); Group 4 received oral DZN (100 mg/kg/day) for one week prior to a single IP dose of IFO on the seventh day. Twenty-four hours post
... Show MoreThe Research aims to determine role of The Intellectual capital in the performance of small and medium enterprises , to achieve this goal through a researcher from the theoretical literature and studies related to the construction of the scheme shows the hypothetical relationship between the variables, which was adopted by the independent variable intellectual capital, distributed four variable are:( human capital, structure capital ,customer capital, innovation capital) as well as four variable (the financial perspective, the customer perspective, process perspective ,the learning & growth perspective) The study were getting to many results as bellow :the intellectual capital in the small and intermediate p
... Show MoreSummary: The study focused on the role of the educational counselor in schools, as an integral part of the educational system that faces multiple challenges and difficulties. In this context, the counselor’s role becomes crucial in attempting to reduce or eliminate such difficulties, in addition to guiding students in an appropriate manner. Methodes: The study employed a descriptive field approach, using interviews and direct observation as tools to examine the actual role performed by school counselors. Results: The study concluded with several key findings, most notably the numerous challenges faced by counselors, including students’ negative behaviors, school dropouts, and the limited administrative support for counselors’ work. Fu
... Show MoreSome genetic factors are not only involved in some autoimmune diseases but also interfere with their treatment, Such as Crohn's disease (CD), Rheumatoid Arthritis (RA), ankylosing spondylitis (AS), and psoriasis (PS). Tumor Necrosis Factor (TNF) is a most important pro-inflammatory cytokine, which has been recognized as a main factor that participates in the pathogenesis and development of autoimmune disorders. Therefore, TNF could be a prospective target for treating these disorders, and many anti-TNF were developed to treat these disorders. Although the high efficacy of many anti-TNF biologic medications, the Patients' clinical responses to the autoimmune treatment showed significant heterogeneity. Two types of TNF receptor (TNFR); 1 an
... Show Moreهدف ال الأسلوب المعرفيّ م الإد ا ركيّ اضة للبنات، والتعرّف على علاقة التنظ ة وعلوم الر ة البدنّ ة التر لّ ة في ات المرحلة الثانّ طال إنّه احثتان اضة للبنات، وأفترضت ال ة وعلوم الر ة البدنّ ة التر ل ة في ات المرحلة الثان عض طال التأمّليّ الاندفاعيّ لدى اس الأسلوب المعرفيّ التأمّليّ الاندفاعيّ لدى عیّنة م الإد ا ركيّ ونتائج مق اس التنظ ة بین نتائج مق
... Show Moreاصبحت وسائل الاعلام في ظل المتغيرات الجديدة قادرة على صياغة وعي وثقافة وهوية الشعوب الى حد كبير في المجتمعات المعاصرة , وذلك نظرا لما تتمتع به من اليات مختصة في التأثير والمتمثلة عموما في التكرار المتنوع للرسالة الاعلامية وقدرة الخطاب الاعلامي في معالجة القضايا المختلفة فضلا عن تقديم المعلومات وغزارتها وشرحها المستفيض , وقد بات من الواضح جدا مدى التأثيرات الكبيرة التي من الممكن ان يحدثها تعرض الافراد للمواق
... Show MoreThe current research aims to investigate the skills of the intended meaning beyond the context when reading poetry among fifth literary students. To achieve the aim of the research, the researcher has followed the descriptive approach and used two tools: an open questionnaire that includes an inquiry about the skills of the intended meaning beyond the poetic context, and a closed questionnaire that were examined by the juries, and modified accordingly. Besides, its validity and stability were examined by applying the study on an exploratory sample of (15) teachers to reach its final version and determine the time required to answer it. Then, the researcher applied it on the research sample of (9
... Show Moreيهدف هذا البحث إلى معرفة أثر استخدام دورة التعلم في اكتساب المفاهيم الصرفية واستخلاصها لدى طالبات قسم اللغة العربية بكلية التربية للبنات وقد صيغت فرضيتان مفادهما أن ؛ 1- لا توجد فروق ذات دلالة إحصائية بين متوسط درجات طالبات المجموعة التجريبية اللاتي يدرسن المادة الصرفية في دورة التعلم ومتوسط درجات طالبات المجموعة الضابطة اللاتي يدرسن المادة الصرفية بالطريقة القياسية لاكتساب المفاهيم. 2- لا توجد فروق ذ
... Show Moreوللتحقق من هدف البحث صيغت الفرضية الصفرية الاتية:
- لا توجد فروق ذات دلالة احصائية عند مستوى (0.05 ) بين متوسط درجات طالبات المجموعة التجريبية التي درست وفقا لاستراتيجية (تنال القمر ) ومتوسط درجات طالبات المجموعة الضابطة التي درست على وفق الطريقة الاعتيادية في مقياس مهارات ما وراء المعرفة .
ولأجل التحقق من صحة هذه الفرضية اجرت الباحثة تجربة استغرقت الفصل الدراسي
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