In this work, the possibility to use new suggested carriers (D= Aspirin, Ibuprofen, Paracetamol, Tramal) is discussed for diclofenac drug (voltarine) by using quantum mechanics calculations. The calculation methods (PM3) and (DFT) have been used for determination the reaction path of (O-D) bond rupture energies. Different groups of drugs as a carrier for diclofenac prodrugs (in a vacuum) have been used; at their optimized geometries. The calculations included the geometrical structure and some of the physical properties, in addition to the toxicity, biological activity, and NLO properties of the prodrugs, investigated using HF method. The calculations were done by Gaussian 09 program. The comparison was made for total energies of reactants, activation energies, and transition states to final products. The suggested prodrugs aim to improve the diclofenac carrier's properties and obtain new alternatives for the approved carriers theoretically.
The Islamic civilizational project has become anurgent necessity when Muslims and Arabs faced in recent years, with serious of challenges and the dangers that surrounded them; Globalization is one of these challenges.
In their growth stages, cities become an aggregation of different urban contexts as a result of development or investment projects with other goals, which creates urban tension at several levels. Previous studies presented different approaches and methods to address specific aspects of urban stress, and thus contemporary visions and propositions varied, which required a field for research. The research, from a review of the proposals, the research problem emerged in need to study the indicators and trends of balanced urban development that address the tensions between different social, economic and urban contexts". Accordingly, the objective of the research is determined as "Building a comprehe
... Show Moreيتناول هذا البحث اساسيات التعامل بين الرسول الأعظم r وبين المخالفين له في المعتقد، وضرورة التسامح الديني الذي أقره الاسلام وطبقه الرسول الكريم r في حياته، وعلمه لأصحابه الكرام t، وأصناف الناس الذين تعايش معهم الرسول r مدة سيرته العطرة، لاسيما الكفار وأهل الكتاب والمنافقين، مستندا إلى كتب التفسير والحديث النبوي الشريف، وقد جعل الباحث لكل منهم مبحثا مستقلا ، ثم انتهى إلى الخاتمة وأهم التوصيات .
The concept of poetics has different dimensions, part of which is related to the creative achievement, and part is related to the critical perspective.
The concept of poetics has different dimensions, part of which is related to the creative achievement, and part is related to the critical perspective. The task of this research
Holly Quran and prophetic sunna is the two main sources for this religion and the formers derived the rules from them directly . the jurisprudent was a scientist in commentary of holly Quran , narrators of prophetic Tradition, jurisprudence and linguistics in the same time. The sciences of commentary , jurisprudence , Tradition and linguistics were integral system without any distinguishing until these sciences started to distinguish in their limits and ranges.
كان لسياسات االحتالل دور بارز في فشل مشروع إعادة بناء الدولة في افغانستان، وفي الوقت نفسه تتحمل دول االحتالل المسؤ و لية الكاملة عن بعض هذه ً كبي ارً السياسات مثل عدم التخطيط الجيد لمرحلة االحتالل وإعادة بناء الدول ة، ثم إن جزءا من فشل هذه السياسات يرجع الى البيئتين المحلية واإلقليمية ، كذلك كان للخبرة السياسية والدستورية وللواقع االجتماعي الثقافي األفغاني تأثيرهما المهم في قدرة المجتمع األفغاني ً على قبول
... Show Moreامن الخليج العربي بين الاحتكار الامريكي و رغبة المشاركة الاوربية