Selexipag is an orally selective long-acting prostacyclin receptor agonist, which indicated for the treatment of pulmonary arterial hypertension. It is practically insoluble in water ( class II, according to BCS). This work aims to prepare and optimized Selexipag nanosuspensions to achieve an enhancement in the in vitro dissolution rate. The solvent antisolvent precipitation method was used for the production of nanosuspension, and the effect of formulation parameters (stabilizer type, drug: stabilizer ratio, and use of co-stabilizer) and process parameter (stirring speed) on the particle size and polydispersity index were studied. SLPNS prepared with Soluplus® as amain stabilizer (F15) showed the smallest particle size 47nm wi

Flexible pavement design and analysis were carried out in the past with semi-experimental methods, using elastic characteristics of pavement layers. Due to the complex interferences between various layers and their time consumption, the traditional pavement analysis, and design methods were replaced with fast and powerful methods including the Finite Element Method (FEM) and the Discrete Element Method (DEM). FEM requires less computational power and is more appropriate for continuous environments. In this study, flexible pavement consisting of 5 layers (surface, binder, base, subbase, and subgrade) had been analyzed using FEM. The ABAQUS (6.14-2) software had been utilized to investigate the influence of the base layer depth on ver

ان التطور التكنولوجي في عناصر انتاج الصورة المسرحية يرتبط بعدة مفردات يتم توظيفها في رسم المنظر المسرحي والذي يرتبط بالمكان مباشرة ، اذ ان الية اشتغال السينوغرافيا في مسرح الطفل تتشكل عبر منظومة الضوء بأجهزتها المختلفة ومؤثراتها الصورية وتقنياتها المتقدمة، اذ يمكن ان يشكل الحضور الكمي والنوعي لتلك المفردتين مسبوقتين بمعرفة فنية تسمح بتحديد فنية التزامن وفنية التركيب، اي بمعنى ان كل قطعة ديكورية يجب ا

The theater has made a qualitative transition at the level of presenting shows by starting from new theatrical spaces and activating the role of formative values through the mass distribution of the elements of creating the scene and granting visual techniques more functions to enhance the theatrical space and create a partnership between the show and the recipient through the actor's performance. The theater director sought to activate the participatory space through the directorial variables and the text of the show and the use of new techniques and the production of participatory spaces and moving towards new spaces and discovering them and leaving traditional spaces. According to the above, the researchers asked (Does the participatory

امتازت النصوص المسرحية بما تحمله من قيم تربوية ورؤى فنية في المسرحية التعليمية من مضامين فكرية واضحة، وأن المسرحية التعليمية ليست محصورة فقط في الحاضر، بل إنها تعمل على استعراض وتوثيق التاريخ والتراث، وتقديمها بشكل يجعلها ملائمة ومثيرة للاهتمام للأجيال الجديدة، ولأنها تلعب دورًا مهمًا في نقل القيم والمعارف وتعزيز التواصل الثقافي بين الماضي والحاضر والمستقبل، وهي وسيلة فعّالة لتعليم الجمهور بطريقة تف

Background: Stromal inflammatory cells in malignant tissue have recently gained increasing interest. Unlike the extensive research on tumor‐infiltrating lymphocytes, published data about tumor‐infiltrating eosinophils in breast cancer are scarce. Furthermore, similar studies have yet to be conducted in Iraq.

Aims: The objective of this study is to examine the presence of eosinophilic infiltration by direct visualization using light microscopy and to analyze its relationship with other histological parameters in a group of Iraqi women diagnosed with invasive mammary cancer.

Methods and material: A retrospective study enrolled 90 h

Diabetic retinopathy is an eye disease in diabetic patients due to damage to the small blood vessels in the retina due to high and low blood sugar levels. Accurate detection and classification of Diabetic Retinopathy is an important task in computer-aided diagnosis, especially when planning for diabetic retinopathy surgery. Therefore, this study aims to design an automated model based on deep learning, which helps ophthalmologists detect and classify diabetic retinopathy severity through fundus images. In this work, a deep convolutional neural network (CNN) with transfer learning and fine tunes has been proposed by using pre-trained networks known as Residual Network-50 (ResNet-50). The overall framework of the proposed

BACKGROUND: Anemia during pregnancy is still a challenge throughout the world, and it may cause severe health consequences in the maternal and fetal sides. AIM: This study aims to find out the prevalence of maternal anemia and potential adverse outcomes in Iraq. METHODS: In Medical City Tertiary Center in Baghdad, singleton pregnant ladies came for delivery were involved over 6 months’ period. Based on hemoglobin (Hb) readings; they were divided into no anemia group (Hb>11 g/l) and anemia group which were further subdivided into mild, moderate, and severe (Hb =10–10.9, =7.1–9.9, and <7 g/l, respectively). Full history and examination were performed by attending obstetrician and pediatrician for the upcoming b

The research article deals with the process of building or rebuilding the state in Iraq after 2003 in its various dimensions, in light of the vision and foundational procedures that were developed and supervised by the United States in cooperation with the new leaders of Iraq based on the mechanism of sectarianethnic representation, and diagnosing the imbalances that arose out of that vision and the accompanying procedures, which led to the emergence of new variables in the political process, especially in the post-ISIS* phase, which produced important challenges to the political system and the Iraqi state. The political dynamics and balances emerging after ISIS* represented at the same time opportunities and risks in the process of