Vitamin D receptor (VDR) is a nuclear transcription factor that controls gene expression. Its impaired expression was found to be related to different diseases. VDR also acts as a regulator of different pathways including differentiation, inflammation, calcium and phosphate absorption, etc. but there is no sufficient knowledge about the regulation of the gene itself. Therefore, a better understanding of the genetic and epigenetic factors regulating the VDR may facilitate the improvement of strategies for the prevention and treatment of diseases associated with dysregulation of VDR. In the present investigation, a set of databases and methods were used to identify putative functional elements in the VDR locus. Histone modifications, CpG Islands, epigenetic marks at VDR locus were indicated. In addition, repeated sequences, enhancers, insulators, transcription factor binding sites and targets of the VDR gene, as well as protein-protein interactions with bioinformatics tools, were reported. Some of these genetic elements had overlapped with CpG Islands. These results revealed important new insight into the molecular mechanisms of the VDR gene regulation in human cells and tissues.
The book Tabaqat al-Faqih by Abu Ishaq al-Shirazi (d. 174 AH / 4801 CE) is considered one of the important sources and dates back to the fifth century AH
يعد كتاب(الفهرست) لإبن النديم أول كتاب جامع في القرن الرابع الهجري ،حصر الكتب و المؤلفات العربية و رصدها في مجالات العلم و المعرفة و الثقافة و الفن ،و اللغة والأدب و الشعر بما يكشف عن النشاط الفكري ، و الحياة العقلية و العلمية للعصر .
Highlights the role of taxes in being a major source of funding sources internal economic and social development, and then, any decrease in tax revenue caused by tax evasion, for example, would weaken the government's ability to finance their investments and core financing private sector investment as a result of reduced ability to increase their reserves's cash banks, as well as the weakening of the effectiveness of tax evasion taxes as a tool to guide economic activity in the framework of service for development, and to achieve justice. And the statement of the reasons for and methods of evasion mandated to pay the tax due on them, whether legitimately or illegal with the statement of the proposed methods to tackle tax evasion and elimina
... Show MoreMeans the current research to study the organization formal and its role in demonstrating aesthetic values of the publications issued by the Telecommunications Company (Asia Cell) in Iraq, where is the organization the formal need for a mission to find the concepts and dimensions of the functional and expressive and aesthetic added to the impact of the actor in achieving the goals set for the publication.
The target is determined by the researcher to disclose the role of formal organization to show the aesthetic values of the publication to reach scientific results
The social support is considered one of the most important constituents of
society and the one which can ensure its unity.
The resources of social support are different accordind to the variety and
the multiplication of the net – work of the social relationships that are
established among the individuals. The importance of this variable is evident
in the emolional adaptation and the mental health as well as its role in mitigating of the illness threating and in accelerating the recovery. social support can enhance the individuals ability to tolerate and face the emotional
and physical problems in the time of cris and stressful life conditions.
The most important results are shown as follows :
1- It was
تعد اللغة العربية العامة من المواد التي تدرسها الطالبات في الصف الأول في كل أقسام كلية التربية للبنات، وقد لاحظ الباحث إن الطالبات يفتقرن الى التعرف الى معاني كثير من الكلمات التي ترد في المقطوعات الأدبية الشعرية منها والنثرية التي يقدمها أستاذ المادة، وبما إن وقت المحاضرة محدود فأنه لا يسمح بالتعرف الى أفكار الطالبات حول معاني هذه الكلمات وقد يضطر الأستاذ أخيرا الى تقديم المعاني جاهزة للطالبات من اجل
... Show Moreيسلط هذا البحث الضوء على ظاهرة لغوية، والتي يطلق عليها تسمية "التضاد". يبين هذا البحث مفهوم هذه الظاهرة، خصائصها، أنواعها، وأسبابها، في اللغتين الساميتين: السريانية والعبرية. حيث تم اعتماد المنهج المقارن في دراسة هذه الظاهرة اللغوية وتبيان وجوه التشابه واالختالف في ماهية هذا النوع من المفردات، أي األضداد، في اللغتين: السريانية والعبرية. ويشير البحث إلى نوعين من التضاد وهما: التضاد الذي يكون بين مفردتين مستقل
... Show MoreThere are many opinions about modern political thoughts for future , trying to draw a map of strong powers in the world and one of these thoughts is the conflict with civilizations. Both of these phenomena search for future and western civilization. It is important to mention that Islamic civilization has special place and clear effect through its conditions.
مشكلة البحث وآهميته :
تعد مرحلة ما قبل المدرسة من المراحل شديدة الأهمية في نمو الأطفال في هذه المرحلة تمتد رغبة الطفل في التعرف على العالم المحيط به ثم تتطور أنشطته لتصبح أكثر عمقا وأتساعا فتتضمن البيئة البعيدة عنه ، هذا فضلا على أن 50% من التنمية الذهنية للطفل تتشكل في السنوات الأربع الأولى من العمر وأن القراءة هي إحدى المكونات الأساسية التي تعززهذا الجانب من التنمية .
( أبو
... Show MoreThose human societies, which based on pluralism and cultural diversity, can be handled with completely consciously، when converting the contradiction to integration and the collision to coexistence and the transition from intolerance to tolerance. This diversity in communities make individuals differ acconding to the following:
1- The requirements of human nature.