The biomarker significance of three chemokines (CXCL8, CXCL10 and CXCL16) was evaluated in sera of 45 breast cancer (BC) and 28 benign breast lesion (BBL) patients, as well as 20 control women. Clinical stage and tumor expression of estrogen (ER), progesterone (PgR) and human epidermal growth factor receptor-2 (HER-2) receptors were considered in this evaluation. The results demonstrated that CXCL8, CXCL10 and CXCL16 showed a significant increased median in BC and BBL patients compared to control (CXCL8: 47.3 and 25.7 vs. 15.0; CXCL10: 37.6 and 30.7 vs. 13.1; CXCL16; 27.9 and 25.2 vs. 19.2 pg/ml, respectively). The increased levels of CXCL8 and CXCL16 were more pronounced in triple-negative and HER-2 positive patients, respectively. Binary logistic regression analysis revealed that CXCL8 was a significant predictor of BC, and such prediction was more depicted in triple-negative patients. The receiver operating characteristic analysis also revealed that CXCL8 recorded an area under curve of 0.998 in BC patients. In conclusion, CXCL8 is a potential biomarker for BC, especially when ER, PgR and HER-2 expression is considered. In this context, the predictive significance of CXCL8 in influencing BC progression is suggested in triple-negative patients.
The line is among a nation of civilized nations did not attain what Muslims took care
الأهمية :
التخطيط بالمعنى العام مارسته بعض الجماعات ، وكثير من الأفراد عبر العصور فهم حاولوا أو يحاولون التحكم في مستقبل حياتهم أو حياة أبنائهم ، وقد حدثنا التأريخ عن بعض التجارب لمواجهة الأزمات والكوارث التي هددت بعض الشعوب ، ولعل قضية سيدنا يوسف عليه السلام وهي تشير الى خطته لمواجهة المجاعة المنتظرة ، ومقوماتها حسن التخزين وضبط الأستهلاك وفترتها الزمنية ، فضلاً عن أمثلة تاريخية لموا
... Show Moreوظائف الدولة (في الفكر السياسي العربي الاسلامي)
Humans have considerations of gender male and female, and many of them have preferential male versus female, and became such considerations solid in the minds of some of the intellectuals, public and most of the people; as a fact for granted, and that's what get them to prefer of boys over females.
تعد الضريبة مصدراً مهماً لتحقيق الاهداف الاقتصادية والاجتماعية والسياسية للدولة ولذلك فان مشكلة التهرب الضريبي تعد اهم المشاكل التي ينبغي معالجتها من خلال معرفة اسبابها . ان وجود مشكلة التهرب الضريبي في العراق يرتبط بمجموعة من الاسباب والدوافع الكامنة وراء ظهور هذه المشكلة والتي لا نستطيع ان نلقي بتباعها على تخلف النظام الضريبي من حيث تشخيص الاختلالات في الادارة الضريبية تارة بل يجب ابراز عيوب التشريع الض
... Show MoreThe research aims at showing the media awareness for Students, especially for the students of the preparatory schools through their following the mass media in forming the cultural, educational and political database. It also aims at building a content and prospectives that make them a wide awake stratum that safeguard the society which has faced huge effects of terrorist actions.
Furthermore, it aims at knowing to what extent that students have been acquainted with the printed and electronic newspapers. Finally, it aims at knowing to what extent that they are content with the mass media in covering and
... Show MoreQuran is a basic reference of production it is as a source to all sciences, Ayat of Quran would mention the importance of benefits of animals. Quran contain full surrat named in animal names as Al-Baqara that is to clarify its benefits and importance in human’s life.
تناولت هذه الدراسة نبات القريص واسمه العلمي Urtica dioica والمجهز من صيدلية الحضر ومن المعشب للتعرف على مكوناته الكيميائية واهم المجاميع الفعالة فيه . بينت هذه الدراسة احتواء النبات على القلويـدات ( alkaloids ) والتانينـات (Tannins ) والصابونيات ( Saponins ) وكانت الدالة الحامضية للمستخلص المائي للنبات المجهز من صيدلية الحضر متعادل بينما
The Holy Qur’an is considered the miracle of God Almighty on earth, that will remain until the Hour of Resurrection, in which are evidences of His Power, Glory be to Him, and its verses are extremely perfect in miraculousness