The biomarker significance of three chemokines (CXCL8, CXCL10 and CXCL16) was evaluated in sera of 45 breast cancer (BC) and 28 benign breast lesion (BBL) patients, as well as 20 control women. Clinical stage and tumor expression of estrogen (ER), progesterone (PgR) and human epidermal growth factor receptor-2 (HER-2) receptors were considered in this evaluation. The results demonstrated that CXCL8, CXCL10 and CXCL16 showed a significant increased median in BC and BBL patients compared to control (CXCL8: 47.3 and 25.7 vs. 15.0; CXCL10: 37.6 and 30.7 vs. 13.1; CXCL16; 27.9 and 25.2 vs. 19.2 pg/ml, respectively). The increased levels of CXCL8 and CXCL16 were more pronounced in triple-negative and HER-2 positive patients, respectively. Binary logistic regression analysis revealed that CXCL8 was a significant predictor of BC, and such prediction was more depicted in triple-negative patients. The receiver operating characteristic analysis also revealed that CXCL8 recorded an area under curve of 0.998 in BC patients. In conclusion, CXCL8 is a potential biomarker for BC, especially when ER, PgR and HER-2 expression is considered. In this context, the predictive significance of CXCL8 in influencing BC progression is suggested in triple-negative patients.
The Praise be to God, Lord of the Worlds, and prayers and peace be upon the Master of the Messengers and his pure and pure family, and may the peace and blessings be abundantly
اشكالية النظرية في العلوم السياسية : مساهمة اولية
Los lingüistas no árabes suelen quedar perplejos a la hora de interpretar el fenómeno de Al-ḍdad, −normalmente traducido en español como palabras autoantónimas (1)− en la lengua árabe, en el que los arabistas, y entre ellos los españoles, han quedado sombrosos ante este fenómeno. El jefe del tribunal de la defensa de mi tesis me pidió que le explicara este fenómeno según mi teoría “El esquema básico de la referencia”; pues me dijo que no podía imaginar que una palabra tuviera dos significados opuestos, y en ese momento le expliqué la palabra albayn البين que significa la separación, o la relación o el enlace que comentar
... Show Moreيقف البحث الموسوم (تجربة الاختيار في الشعر الجاهلي وصدر الاسلام)، على العديد من النماذج الشعرية، التي عاش فيها الشاعر العربي تجربة الاختيار في العصر الجاهلي وصدر الاسلام، واتجه البحث الى تحليل العديد من النماذج المختارة من التراث العربي الشعري، وقد وقف البحث على بعض التجارب التي يقع فيها الشاعر في موقف الاختيار. و لذلك كان من المنطق ان يقسم البحث الى مبحثين: فكان الاول منها يقف على (تجربة الاختيار في الشعر
... Show MoreThis paper deals with studying of one of the shrine that buried in Khizran
that had considered one of the ancient cemetery in Baghdad ,it is
Mohammad Basha
the source of Fiqh do not give areal picture for the efforts which have been done for economic system of the taxes But it gives a special ideas about what must be done.
Appearance of the Kurdish press in the Kurdish literature was affected by as set of both external and internal factors. The former was realized in the spreading of press and publications especially at the neighboring countries in the second half of the 19th century. The latter factors, external ones ,were concerned the political situations undergone by the Kurdish people who severely suffered injustice practiced by the Othman authority .All these reasons had driven the educated to migrate to search for more safe places to practice their cultural actions with absolute freedom. Consequently, the first newspaper was issued on 22/4/1898 in Cairo which pointed the birth of the Kurdish press inside and outside Kurdistan region which
... Show MoreThis research has been devoted to the study narratines of the metaphysical concepts in Egypt during the Mamluk era ( 648-923 AD/1250-1517 AH). The study consists of three sections and an introductionwhich highlights the study at that time for its great impaction public life in Egypt.
This paper deals with an important aspect of creativity in the poetry of Ibn Zaidoun, a senior poets Andalusians and writers
تعـد الوحـدة الوطنيـة لأي شـعب قاعـدة الارتكـاز للبنـاء الحضـاري والتقـدم والتطـور والتنميـة في المجـالات كافـة وبغيابها يفقد الشعب المرتكزات الأساسية لآمنه واستقراره، وقدرته على احتواء الأزمات الناشئة عن الاختلافات العرقيـة والدينية والطائفية، وعلى هذا الأساس فان قيادات الشعب الوطنية يكون هاجسها الدائم الحفاظ على الوحدة الوطنية، وسـد كـل الثغـرات والمنافـذ في جـدرانها لكـي لاتنفـذ مـن خلالهـا ريـاح
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