The biomarker significance of three chemokines (CXCL8, CXCL10 and CXCL16) was evaluated in sera of 45 breast cancer (BC) and 28 benign breast lesion (BBL) patients, as well as 20 control women. Clinical stage and tumor expression of estrogen (ER), progesterone (PgR) and human epidermal growth factor receptor-2 (HER-2) receptors were considered in this evaluation. The results demonstrated that CXCL8, CXCL10 and CXCL16 showed a significant increased median in BC and BBL patients compared to control (CXCL8: 47.3 and 25.7 vs. 15.0; CXCL10: 37.6 and 30.7 vs. 13.1; CXCL16; 27.9 and 25.2 vs. 19.2 pg/ml, respectively). The increased levels of CXCL8 and CXCL16 were more pronounced in triple-negative and HER-2 positive patients, respectively. Binary logistic regression analysis revealed that CXCL8 was a significant predictor of BC, and such prediction was more depicted in triple-negative patients. The receiver operating characteristic analysis also revealed that CXCL8 recorded an area under curve of 0.998 in BC patients. In conclusion, CXCL8 is a potential biomarker for BC, especially when ER, PgR and HER-2 expression is considered. In this context, the predictive significance of CXCL8 in influencing BC progression is suggested in triple-negative patients.
الفاظ القرأن المجيد في الديوان الفرسي
There is a fact we have to admit here, first, that is art innovation, since
its early beginnings, is mostly a male product, and causing to stir interest and
attention, if it was a female one. Psychiatrist and sociologists could give us a
convincing answer or a logical explanation for that. What is really important
here is how the male artist could review his vision to woman, what was the
impact of all these ideas and desires towards each other in their artistic
products? Did he reflect the real role played by the woman in pushing the
artist towards specific ways? Did it related to the struggle for immortality? In
searching for motherhood and life eternity and the partner to find the way to
life. We, often, find
Sıfat - Fiillere Osmanlıcada fer’i fiil adı verilmektedir. Sıfat - fiiller için çeşitli kaynaklarda, kılın adı (kılın sanı[1]), ortaç[2], sıfat - fiil (sıfat - eylem[3]), partisip[4], isim - fiil[5] gibi terimler kullanılmıştır.
Sıfat - fiiller, isim- fiiler gibi fiilden türerler. Aldıkları belli başlı ekler vardır. Bu eklere sıfat - fiil ekleri denir.sıfat - fiiller, cümlede bir sıfat gibi görev yaparlar. Sıfatlar gibi isimlerin önün gelirler ve onları nitelerler tıpkı bir sıfat gibi ismin hal eklerini alab
... Show Moreجاء ابن كثير في عصر نشط فيه التأليف في كل فن من فنون الدراسات الدينية والعربية، ومن الطبيعي أن يكون التأليف في ميدان السيرة النبوية مواكبًا لهذا النشاط الذي استقى مواده ونصوصه من الثروة الضخمة من الكتب والآراء والروايات التي سجلها العلماء والمحدثون والحفاظ قبل ذلك العصر.
يتناول هذا المقال تصورًا مستقبليًا لمؤسسات المعلومات في عام 2050، حيث يستعرض كيف ستتغير بنيتها لتصبح ذكية ومستدامة، ويستعرض دور أخصائي المعلومات في بيئة رقمية متقدمة. كما يناقش تطور مصادر المعلومات وخدماتها، ونُظم تنظيمها، بالإضافة إلى تنوع المستفيدين، مع إبراز دور هذه المؤسسات في دعم التنمية المستدامة
Agriculture is one of the important job in the human life. Since the first beginning of humanity life, agriculture was the basis property in order to get individual foods. The Holy Quran and Hadith were supplied agriculture and all Muslims were followed this field especially after Islamic state expansion and its possessive many lands which developed directly our Islamic civilization.
نماد گرایی وجانوران در منطق الطیر
الغنائية في الشعر ميخا يوسف ليبنزون
يعد التنافس امر اعتيادي في المعاملات الدولية وبين الدول لاسيما في الوقت الحالي فهي لا تدخل في نزاع او حرب او حتى ازمة