Design, Synthesis and Cytotoxicity Study of Primary Amides as Histone Deacetylase Inhibitors
primary amides
HDACIs
adipic monoanilide amide
pimelic monoanilide amide
Primary amide derivatives as histone deacetylase inhibitors (HDACIs) are very rare. This paper describes the synthesis of primary amide derivatives (compounds 6 and 7) that have the requirements to be histone deacetylase inhibitors of the zinc-binding type. Both of them exhibited good cytotoxicity against the tested cancer cell lines with much lower cytotoxicity against normal cell line.
